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BALTIMORE, MD, United States

Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase II | Award Amount: 1.22M | Year: 2009

DESCRIPTION (provided by applicant): The overall goal of this project is to develop, formally benchmark and validate a new flow sensor that will accurately quantify varying degrees of ventilation in pediatric and adult patient populations. The flow sensor is a simple, non-contact, disposable part that provides quantitative measurement of respiratory activity, even in the low-flow range. Current technologies lack the ability to accurately measure tidal volume but rather provide a semi-quantitative measure of respiratory patterns. A pneumotachograph (which can provide quantitative data) is too burdensome on patient comfort and breathing effort to obtain long term respiration measurements. Self-funded preliminary prototypes were developed prior to this grant submission and tested at the Johns Hopkins Sleep Disorders Center in Baltimore. The prototypes performed comparable to the gold standard (pneumotachograph). This project will finish development of the design, formally benchmark the flow sensor with the pneumotachograph, as well as examine the stability and accuracy of the design. Following this, the design will undergo planned improvements related to patient comfort and compliance. The project will conclude with formal clinical validation studies at overnight sleep clinics across a spectrum of patients to compare and validate the new flow sensor to current technology. Final design modifications will focus on optimization of a plug-and-play interface thereby simplifying integration with existing polysomnographic recording units and improving technician ease of use and patient comfort. The data and prototypes generated by this application will ultimately translate into improved care of patients that are susceptible to ventilatory failure and eventually as an ambulatory diagnostic system for patients in the home setting. This flow sensor will have an immediate impact on patient monitoring in sleep laboratories and will further influence diagnostic procedures in pulmonary medicine, anesthesia and other medical disciplines.


Patent
Key Technologies, Inc. | Date: 2013-03-22

The present invention relates to novel materials particularly useful for ophthalmic applications and methods for making and using the same. More particularly, the present invention relates to relatively soft, optically transparent, foldable, high refractive index materials particularly suited for use in the production of intraocular lenses, contact lenses, and other ocular implants and to methods for manufacturing and using the same.


Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase II | Award Amount: 1.25M | Year: 2011

DESCRIPTION (provided by applicant): This project will develop new surgical tools and procedures to facilitate a minimally invasive repair for uterine or vaginal vault prolapsed, a disorder of the female pelvic floor. The current gold standard operation for this disorder is the sacral colpopexy, primarily performed via laparotomy in which a relatively large abdominal incision is made to access the area in a manner similar to that performed for a cesarean section or abdominal hysterectomy. This procedure hasa high success rate but entails the pain and morbidity associated with the large abdominal incision. A small but increasing number of surgeons are now performing sacral colpopexy via laparoscopy or robot-assisted laparoscopic surgery, including a novel technique that utilizes a single 2-3 cm umbilical incision. Although feasible, the current laparoscopic equipment has deficiencies that make this procedure difficult, limiting its practice to those with advanced laparoscopic skills who are willing to undergoa steep learning curve. Even when performed by experienced surgeons, sacral colpopexy performed laparoscopically or robotically requires longer operative times and increased operating room (OR) personnel when compared to open sacral colpopexy. This project will transform this gold standard procedure into one that is primarily performed via laparoscopy or robot-assisted laparoscopic surgery, including the single-incision / single-port approach. This will reduce hospital stays, potentially decrease blood loss and operative morbidity, reduce post- operative pain, and support an earlier return to normal activities. It will also allow the procedure to be rendered more efficiently, with a shorter learning curve and a reduction in OR personnel and costs. Beyond the sacral colpopexy, the equipment and tooling being proposed will provide a platform for a range of female pelvic surgery procedures, most notably, the laparoscopic or laparoscopically assisted hysterectomy. This project will be completed in several sequential stages. First, the preliminary surgical tools and procedures will be finalized (based on designs and feasibility testing completed in Phase I). Next, the tools and procedures will be tested in a cadaver model, which is intended to prove the safety andperformance of the tools and procedures. The project will conclude with human subject testing that will demonstrate safety and performance in human subjects, which will include post-operative follow up. An outside panel of medical peers will be formed tofollow the project, to provide feedback on the safety and efficiency of the approach and tooling and to suggest improvements. PUBLIC HEALTH RELEVANCE: Each year, approximately 200,000 women undergo inpatient procedures related to pelvic organ prolapsed in the United States and it is expected that this number will rise with the aging population. A current surgical repair procedure (known as sacral colpopexy ) is typically performed via laparotomy in which a relatively large abdominal incision is madeto access the pelvic area (similar to that performed for a cesarean section or abdominal hysterectomy). This project will develop an improved laparoscopic approach that will use minimally invasive techniques to perform this procedure using very small patient incisions. This is expected to decrease operative morbidity, reduce patient pain and recovery time, and shorten hospital stays and costs.


Patent
Key Technologies, Inc. | Date: 2014-10-17

Novel methods and materials particularly useful for ophthalmic applications and to methods for making and using the same are disclosed herein. More particularly, relatively soft, optically transparent, foldable, high refractive index materials particularly suited for use in the production of intraocular lenses, contact lenses, and other ocular implants and to methods for manufacturing and implanting IOLs made therefrom are disclosed.


Patent
Key Technologies, Inc. | Date: 2015-04-13

The present invention relates to novel materials particularly useful for ophthalmic applications and methods for making and using the same. More particularly, the present invention relates to relatively soft, optically transparent, foldable, high refractive index materials particularly suited for use in the production of intraocular lenses, contact lenses, and other ocular implants and to methods for manufacturing and using the same.

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