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Yao J.-P.,Wuhan University of Science and Technology | Yao J.-P.,Chongqing Key Laboratory of Visual Damage and Regeneration and Restoration | Tai Z.,Chongqing Broadcasting Group | Tai Z.,Chongqing Key Laboratory of Visual Damage and Regeneration and Restoration | And 2 more authors.
International Journal of Ophthalmology | Year: 2013

AIM To construct a new visual acuity measuring function for congenital nystagmus (CN) patients by studying the relationships between acuity, velocities and positions of the eye. METHODS After assessing the relationship between acuity, movement velocities and positions of the eye separately, a new function, which we call the automated nystagmus acuity function (ANAF), was constructed to measure the visual acuity of CN patients. Using a high-speed digital video system working at 500 frames per second, each eye was calibrated during monocular fixation. Twenty-six recorded nystagm us data were selected randomly. Using nystagmus waveforms, the best vision position (foveation period) and visual acuity were analyzed in three groups of subjects, and then all outputs were compared with the well-known expanded nystagmus acuity function (NAFX) and ANAF. Standard descriptive statistics were used to summarize the outputs of the two programs. RESULTS Foveation periods were brief intervals in the CN waveform when the image was on or near the fovea and eye velocity was relatively slow. Results showed good visual acuity happened during the period when velocity was low and the eye position was near the zero position, which fitted the foveation periods. The data analyzed with NAFX and ANAF had a correlation coefficient of 0.934276, with an average error of -0.00973. CONCLUSION The results from ANAF and NAFX analyses showed no significant difference. The NAFX manually identifies foveation eye positions and produces accurate measurements. The ANAF, however, can be calculated simply using the factors eye position and velocity, and it automatically calculates the ANAF without the need to manually identify foveation eye positions. © Copyright International Journal of Ophthalmology Press. Source


Yao J.-P.,Chongqing University | Yao J.-P.,Chongqing Key Laboratory of Visual Damage and Regeneration and Restoration | Hou W.-S.,Chongqing University | Hou W.-S.,Chongqing Key Laboratory of Visual Damage and Regeneration and Restoration | And 2 more authors.
International Journal of Ophthalmology | Year: 2012

Optogenetics is a new and rapidly evolving gene and neuroengineering technology that allows optical control of specific populations of neurons without affecting other neurons in the brain at high temporal and spatial resolution. By heterologous expression of the light-sensitive membrane proteins, cell type-specific depolarization or hyperpolarization can be optically induced on a millisecond time scale. Optogenetics has the higher selectivity and specificity compared to traditional electrophy siological techniques and pharm aceutical methods. It has been a novel promising tool for medical research. Because of easy handling, high tem poral and spatial precision, optogenetics has been applied to many aspects of nervous system research, such as tactual neural circuit, visual neural circuit, auditory neural circuit and olfactory neural circuit, as well as research of some neurological diseases. The review highlights the recent adv ances of optogenetics in medical study. Copyright International Journal of Ophthalmology Press. Copyright International Journal of Ophthalmology Press. Source

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