Key Laboratory of the Ministry of Edu for Conser and Utili of Special Biological Resou in Western China

Yinchuan, China

Key Laboratory of the Ministry of Edu for Conser and Utili of Special Biological Resou in Western China

Yinchuan, China
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Yang Y.,Key Laboratory of the Ministry of Edu for Conser and Utili of Special Biological Resou in Western China | Yang Y.,Ningxia University | Xu J.R.,Key Laboratory of the Ministry of Edu for Conser and Utili of Special Biological Resou in Western China | Xu J.R.,Ningxia University | And 10 more authors.
Genetics and Molecular Research | Year: 2014

In the present study, the correlation of polymorphisms of the apolipoprotein E (apoE) gene with the susceptibility of essential hypertension (EH) was investigated. Single nucleotide polymorphisms of the apoE gene at the -491 A>T, +969 C>G, and +2836 G>A sites were determined in 221 non-EH individuals and 109 subjects with EH of Chinese Hui ethnicity using polymerase chain reaction-restriction fragment length polymorphism analysis. The results showed that neither the genotypic frequency nor the allelic frequency at the -491 A>T and +969 C>G sites exhibited a statistically significant difference between these two groups (P > 0.05). However, a significant difference was observed in genotypic frequency and allelic frequency at the +2836 G>A site between EH patients and non-EH individuals (P < 0.01). In addition, a significantly higher frequency of the A allele at the +2836 G>A site was also detected in EH patients (83%) compared with controls (47.5%) (P < 0.01; OR = 4.82, 95%CI = 3.25-7.17); in contrast, the frequency of the G allele at the +2836 G>A site was significantly lower (17%) in the patient group in comparison with the non-EH cohorts (52.5%) (P < 0.01; OR = 0.21, 95%CI = 0.14- 0.31). These results suggest that the polymorphism at the +2836 G>A site in the apoE gene is strongly correlated with the susceptibility to EH in the Chinese Hui ethnic population. © FUNPEC-RP.

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