Key Laboratory of TCM Information Engineer of State Administration

Beijing, China

Key Laboratory of TCM Information Engineer of State Administration

Beijing, China
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Ding H.,Beijing University of Chinese Medicine | Ding H.,Civil Aviation General Hospital | Yin Q.,Capital Medical University | Wan G.,Capital Medical University | And 5 more authors.
International Journal of Pharmaceutics | Year: 2015

Menthol (M) and platycodin D (PD) are the main active ingredients in Mentha haplocalyx and Platycodon grandiflorum A. DC., respectively. They are commonly used in combination in traditional Chinese medicine. In this study, laboratory experiments and computer simulations were used to investigate the solubilization of M by PD, which was believed to be one of the main causes of the synergistic effect of M. haplocalyx and P. grandiflorum A. DC. Results showed that both the method by which M was added and the concentration of PD had significant effects on the solubilization efficiency of M, and these influences were closely associated with each other. Temperature, an important environmental condition, was also found to have a significant effect on the solubilization effect of PD. These findings not only clarify the molecular basis of the solubilization effect, including amount solubilized at the macroscale and the structures of the micelles, and the drug loading mechanisms and processing at the mesoscale. This work may provide some guidance for the further development of saponins and fundamental research in the drug delivery system. © 2015 Elsevier B.V. All rights reserved.


Pei Y.,Beijing University of Chinese Medicine | Pei Y.,Key Laboratory of TCM Information Engineer of State Administration | Wu Z.,Beijing University of Chinese Medicine | Wu Z.,Key Laboratory of TCM Information Engineer of State Administration | And 8 more authors.
Journal of Innovative Optical Health Sciences | Year: 2015

Near infrared (NIR) assignment of Isopsoralen was performed using deuterated chloroform solvent and two-dimensional correlation spectroscopy (2D-COS) technology. Yunkang Oral Liquid was applied to study Isopsoralen, the characteristic bands by spectral assignment as well as the bands by interval partial least squares (iPLS) and synergy interval partial least squares (siPLS) were used to establish partial least squares (PLS) model. The coefficient of determination in calibration (Rcal 2) were 0.9987, 0.9970 and 0.9982. The coefficient of determination in cross validation (Rval 2) were 0.9985, 0.9921 and 0.9982. The coefficient of determination in prediction (Rpre 2) were 0.9987, 0.9955 and 0.9988. The root mean square error of calibration (RMSEC) were 0.27, 0.40 and 0.31 ppm. The root mean square error of cross validation (RMSECV) were 0.30, 0.67 and 0.32 ppm. The root mean square error of prediction (RMSEP) were 0.23, 0.43 and 0.22 ppm. The residual predictive deviation (RPD) were 31.00, 16.58 and 32.41. It turned out that the characteristic bands by spectral assignment had the same results with the chemometrics methods in PLS model. It provided guidance for NIR spectral assignment of chemical compositions in Chinese Materia Medica (CMM). © 2015 The Author(s).

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