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Yu Y.-Z.,Key Laboratory of State Ministry of Education for Pharmaceutical Technology | Yu Y.-Z.,Zhengzhou University | Zhang X.-H.,Key Laboratory of State Ministry of Education for Pharmaceutical Technology | Zhang X.-H.,Zhengzhou University | And 10 more authors.
Gao Xiao Hua Xue Gong Cheng Xue Bao/Journal of Chemical Engineering of Chinese Universities | Year: 2017

The solubility of pregabalin form I in water, methanol, ethanol, acetone, tetrahydrofuran, N, N-dimethylformamide, ethyl acetate and acetone-water mixed solvents was measured at 283.15~328.15K by equilibrium methods. The experimental results show that the solubility of pregabalin form I in those selected pure solvents and acetone-water mixed solvents increases with the increase of temperature, while it decreases with the increase of mole fraction of acetone in acetone-water mixture. The solubility is close to zero when the mole fraction of acetone in the mixture is ~0.83. The experimental data is well correlated by modified Apelblat empirical equation and (CNIBS)/Redlich-Kister equation, respectively. The solubility data and models obtained are useful for the study of industrial crystallization and drug polymorphism. © 2017, Editorial Board of “Journal of Chemical Engineering of Chinese Universities”. All right reserved.


Zhou J.,Zhengzhou University | Zhou J.,Key Laboratory of State Ministry of Education for Pharmaceutical Technology | Chen S.,Zhengzhou University | Luo P.,Zhengzhou University | And 4 more authors.
Journal of the Chinese Chemical Society | Year: 2015

The screening conditions of an existing column and mobile phase selection strategy for chiral compounds in normal-phase high performance liquid chromatography (NP-HPLC) were tested for their applicability on Chiralpak IC, which is a chiral stationary phase (CSP) made by immobilising cellulosic tris (3,5-dichlorophenyl-carbamate) on silica gel. In this study, the applicability of the optimization steps of the existing separation strategy was examined using 36 compounds representing the three possible resolution situations that occur after screening. The cumulative number of separated compounds is 27 (75.0 %), and the cumulative number of baseline separated compounds is 19 (52.8 %). © 2015 The Chemical Society Located in Taipei & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany.


Zhou J.,Zhengzhou University | Zhou J.,Key Laboratory of State Ministry of Education for Pharmaceutical Technology | Pei W.,Zhengzhou University | Zheng X.,Zhengzhou University | And 3 more authors.
Journal of Chromatographic Science | Year: 2015

A novel cyclodextrin (CD) derivative mono(6A-N-allylamino-6A-deoxy)per-3-chlorine-4-methyl-phenylcarbamoylated-β-CD was synthesized and chemically immobilized onto the surface of γ-mercaptopropyl-functionalized silica gel step by step. The products were all purified and characterized and then got a substance with definitional structure. This chiral stationary phase (CSP) of 3-chlorine-4-methyl-phenylcarbamoylated-β-CD bonded on silica gel exhibited excellent separation capability for several chiral compounds in high-performance liquid chromatography. In the enantiomeric separations of five racemates with a mixture of methanol and aqueous KH2PO4 buffer as the mobile phase, this CSP presented good chiral recognition performance. © The Author 2014. Published by Oxford University Press.


Zhou J.,Zhengzhou University | Zhou J.,Key Laboratory of State Ministry of Education for Pharmaceutical Technology | Sun F.,Zhengzhou University | Du Q.,Zhengzhou University | And 2 more authors.
Journal of Chromatographic Science | Year: 2016

A novel chiral stationary phase was prepared by bonding a novel β-cyclodextrin derivative on silica gel, and it was used for the separation of timolol in high efficiency liquid phase. In the reverse mode, the factors such as the proportion of chiral additives, flow rate, column temperature, repeatability and stability were investigated. The optimum chromatographic conditions are as follows: column temperature was 25°C, flow rate was 0.6 mL min-1 and mobile phase was methanol-25 mM KH2PO4 (80/20, v/v). The chiral column has good reproducibility (Rs = 4.49, 4.51 and 4.40, respectively) and a certain degree of stability (Rs = 4.49, 3.01 and 0.72, respectively). This chiral stationary phase presented good chiral recognition performance toward timolol with good resolution (Rs = 4.49). © 2015 The Author 2015.


Zhou J.,Zhengzhou University | Zhou J.,Key Laboratory of State Ministry of Education for Pharmaceutical Technology | Du Q.,Zhengzhou University | Sun F.,Zhengzhou University | And 3 more authors.
Chirality | Year: 2015

A new liquid chromatographic method has been developed for the chiral separation of the enantiomers of intermediates in the preparation of the ester side-chain of homoharringtonine. The enantiomers were separated by a Chiralpak IC (250 × 4.6 mm, 5 μm) in normal phase high-performance liquid chromatography (HPLC). Four compounds were baseline resolved. By comparing the chromatographs of racemates and single enantiomers of the six intermediates, the enantiomeric excess values of the single enantiomers were evaluated, and the elution orders of the enantiomers were established. Chirality 27:538-542, 2015. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.


Jie Z.,Zhengzhou University | Jie Z.,Key Laboratory of State Ministry of Education for Pharmaceutical Technology | Qiuzheng D.,Zhengzhou University | Suzhen Z.,Zhengzhou University | And 4 more authors.
Journal of Chromatographic Science | Year: 2015

Three stereoselective HPLC methods have been developed for the chiral separation of the enantiomers of three intermediates in the preparation of (+)-tanikolide. The enantiomers were separated on Chiralpak IC (250 × 4.6 mm, 5 μm) in normal phase HPLC. Three intermediates were all baseline separated (RS = 2.84, 2.58 and 3.58, respectively). By comparing the chromatograms of racemates and single enantiomers of the three intermediates, the e.e. values of the single enantiomers were determined and calculated. © 2014 The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

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