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Cai B.,Nanjing University | Cai B.,Nanjing Haichang Chinese Medicine Group Co. | Cai B.,Key Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing | Qin K.,Nanjing University | And 9 more authors.
Progress in Chemistry | Year: 2012

Chinese medicine processing is a traditional Chinese pharmaceutical technology, and it is also the main characteristic property that distinguish traditional Chinese medicine and natural medicine. There are complex chemical changes during the process of Chinese medicine processing, and these chemical constituents which changed during processing maybe the basis of clinical efficacy changes. To clarify the changes of the chemical constituents and the chemical reactions in Chinese medicine during the processing process is the main purpose of the chemical mechanism research of Chinese medicine processing. In recent years, many research institutions at home and abroad have done deeply research in chemical mechanism during the process of Chinese medicine processing. The chemaical reactions and chemical mechanisms ocurred in some traditional Chinese medicines during the process of Chinese medicine processing were initially clarified. The main chemical reactions occurred in the Chinese medicine processing are hydrolysis reaction, oxidation reaction, replacement reaction, isomerization reaction, decomposition reaction, etc. The main achievements in the chemical mechanism research during the process of Chinese medicine processing are reviewed. The research directions and future in the chemical mechanism research of Chinese medicine processing are prospected. Source


Qin K.-M.,Nanjing University | Qin K.-M.,Nanjing Haichang Chinese Medicine Group Co. | Qin K.-M.,Key Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing | Shu Y.-C.,Nanjing University | And 13 more authors.
Chinese Traditional and Herbal Drugs | Year: 2013

Chinese materia medica (CMM) processing is one of the characteristics and advantages of traditional Chinese medicine (TCM), which is also an important discipline with our independent intellectual property rights. The mechanism of CMM processing is the key point of CMM research, which is also the key node of CMM modernization. Most mechanisms of CMM processing are unclear until now, which request the systematical and deep research. Raw and processed Rehmanniae Radix have the different pharmacological effects in clinical application, because there are lots of chemical reactions occurred during the steaming process. In the recent years, scientists all over the world have done lots of research on the changes and mechanisms of Rehmanniae Radix by steaming process under high temperature, and series of research achievements were obtained with the application of many new methods and technologies. These achievements provide not only many new ideas and methods for the mechanism exploration of CMM processing, but also the demonstration for researching and clarifying the mechanisms of CMM processing. Source


Liu Q.,Nanjing University | Liu Q.,Nanjing Haichang Chinese Medicine Group Co. | Liu Q.,Key Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing | Qin K.,Nanjing University | And 8 more authors.
Acta Chromatographica | Year: 2015

To evaluate the quality of Fructus Arctii, an accurate and reliable method of high-performance liquid chromatography/diode array detection-electrospray ionization- mass spectrometry (HPLC/DAD-ESI-MS) was developed. Nine compounds, including chlorogenic acid, caffeic acid, trans-p-hydroxycinnamic acid, arctiin, arctignan A, ethyl caffeate, matairesinol, arctigenin, and lappaol B, were determined simultaneously in 19 batches of Fructus Arctii samples collected from different localities. Nineteen common peaks were identified or tentatively assigned by comparing their mass spectrometric data with reference compounds, self-established compound library, and published literatures. Also, the 19 common peaks were selected as characteristic peaks to assess the similarity of chromatographic fingerprinting of these samples. Moreover, hierarchical clustering analysis (HCA) and principal components analysis (PCA) were successfully applied to demonstrate the variability of samples. The results indicated the content of nine compounds that varied greatly among the samples, and 19 samples collected from different localities could be discriminated. Furthermore, chlorogenic acid, arctiin, and arctigenin were found to be chemical markers for evaluating the quality of Fructus Arctii. © 2014 Akadémiai Kiadó, Budapest. Source


Liu Q.-D.,Nanjing University | Liu Q.-D.,Nanjing Haichang Chinese Medicine Group Co. | Liu Q.-D.,Key Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing | Qin K.-M.,Nanjing University | And 8 more authors.
Chinese Journal of Natural Medicines | Year: 2015

The present study was designed to optimize the processing of Fructus Arctii by response surface methodology (RSM). Based on single factor studies, a three-variable, three-level Box-Behnken design (BBD) was used to monitor the effects of independent variables, including processing temperature and time, on the dependent variables. Response surfaces and contour plots of the contents of total lignans, chlorogenic acid, arctiin, and arctigenin were obtained through ultraviolet and visible (UV-Vis) monitoring and high performance liquid chromatography (HPLC). Fructus Arctii should be processed under heating in a pot at 311 °C, medicine at 119 °C for 123s with flipping frequently. The experimental values under the optimized processing technology were consistent with the predicted values. In conclusion, RSM is an effective method to optimize the processing of traditional Chinese medicine (TCM). © 2015 China Pharmaceutical University. Source


Chen L.-W.,Nanjing University | Chen L.-W.,Key Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing | Qin K.-M.,Nanjing University | Qin K.-M.,Key Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing | And 8 more authors.
Chinese Traditional and Herbal Drugs | Year: 2014

During the study of modernization of Chinese materia medica (CMM), the fingerprinting technology, as the model of the quality control of CMM, is gradually accepted by the world. But how to realize the fast matching, retrieval, recognition, and identification function of CMM fingerprint data is an urgent problem in the study of fingerprint. Studying and establishing CMM fingerprint database, which helps to speed up the study and application process of CMM fingerprinting technology, provides a favorable platform for the promotion and application of fingerprinting technology. This paper summarized the problems in the CMM fingerprint database research and prospected its bright future. ©, 2014, Editorial Office of Chinese Traditional and Herbal Drugs. All right reserved. Source

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