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Zhang J.,Key Laboratory of Radiopharmaceuticals | Zhang J.,Beijing Normal University | Yu Q.,Key Laboratory of Radiopharmaceuticals | Yu Q.,Beijing Normal University | And 15 more authors.
Journal of Radioanalytical and Nuclear Chemistry | Year: 2010

The dimercaptosuccinic acid metronidazole ester (DMSAMe) was synthesized and radiolabeled with 99mTc to form the 99mTc-DMSAMe complex in high yield. The radiochemical purity of the 99mTc-DMSAMe complex was over 90%, as measured by TLC and by HPLC, without any notable decomposition at room temperature over a period of 6 h. Its partition coefficient indicated that it was a lipophilic complex. The tumor cell experiment and the biodistribution in mice bearing S 180 tumor showed that the 99mTc-DMSAMe complex had a certain hypoxic selectivity and accumulated in the tumor with high uptake and good retention. The tumor/blood and tumor/muscle ratios increased with time, suggesting it would be a possible tumor hypoxia imaging agent. © 2010 Akadémiai Kiadó, Budapest, Hungary.

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