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Gao H.-Y.,Shihezi University | Li G.-Y.,Shihezi University | Li G.-Y.,Key Laboratory of Phytomedicine Resources and Modernization of TCM | Wang J.-H.,Shihezi University | And 2 more authors.
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

A sensitive and accurate method for the simultaneous determination of five alkaloids, namely 9α-hydroxymatrine (M1), matrine (M2), sophoridine (M3), oxymatrine (M4), alopecurin A (M5) in different parts (seed, legume, stem, and root) and different harvest times of Sophora alopecuroides L. was developed by high performance liquid chromatography (HPLC) with photodiode array detector (PDA) for the first time. The separation by gradient elution was achieved on Scienhome Kromasil C18 (4.6×250mm, 5μm) column at 30°C with acetonitrile (A)/0.1% phosphatic acid+0.1% triethylamine (B) as the mobile phase. The detection wavelength was 205nm. The optimized method provided a good linear relation (r≥0.9993 for all the target compounds), satisfactory precision (RSD values less than 2.3%) and good recovery (96.4-103.6%). The limits of detection ranged between 0.11×10-3 and 4.70×10-3μg for the different analytes. The method was successfully applied to analysis and quality control of alkaloid extracts from the traditional Chinese herbal drugs of S. alopecuroides L. © 2011 Elsevier B.V. Source

Gao J.-B.,Shihezi University | Li G.-Y.,Shihezi University | Huang J.,Shenyang Pharmaceutical University | Wang H.-Y.,Shihezi University | And 4 more authors.
Journal of Asian Natural Products Research

A new tetracyclic triterpenoid compound named as mastichinoic acid A (1) was isolated from Mastich. The structure was established as 3,7-dioxo-11β- hydroxy-5α-tirucalla-8,24(Z)-dien-26-oic acid by various spectroscopic techniques including MS, 1D, and 2D NMR and HRTOFMS. © 2013 Taylor & Francis Group, LLC. Source

Gao H.-Y.,Shihezi University | Gao H.-Y.,Shenyang Pharmaceutical University | Li G.-Y.,Shihezi University | Wang J.-H.,Shihezi University | And 2 more authors.
Helvetica Chimica Acta

Alopecurin A, an alkaloid with an unprecedented skeleton, was isolated from the seeds of Sophora alopecuroides L. The absolute configuration and structure of this compound was identified as (3S,12R)-3-hydroxy-1,7-diazatricyclo[10.4.0. 1 3,7]heptadecane-11,16,17-trione (=(7S,15aR)-decahydro-7-hydroxy-6H- 7,11-methano-4H-pyrido[1,2-a][1,7]diazacyclododecine-4,15,16(12H)-trione). The structure and absolute configuration was elucidated by spectroscopic methods, mainly HR-ESI-TOF-MS, IR, 1D-NMR ( 1H- and 13C-NMR), 2D-NMR (COSY, NOESY, HSQC, HMBC), and particularly X-ray crystal-diffraction and CD spectral analysis. Copyright © 2012 Verlag Helvetica Chimica Acta AG, Zürich, Switzerland. Source

Peng Q.,Shenyang Pharmaceutical University | Li G.,Shihezi University | Li G.,Key Laboratory of Phytomedicine Resources and Modernization of TCM | Ma Y.,Shenyang Pharmaceutical University | And 5 more authors.
Biochemical Systematics and Ecology

Phytochemical investigation of the dried roots of . Euphorbia kansui resulted in the isolation of three flavonoids (. 1-3), three diterpenoids (. 4-6) and five triterprnoids (. 7-11). Among them, three compounds (. 1-3) were firstly isolated from the family Euphorbiaceae. Others were reported in the genus . Euphorbia, in which three compounds (. 8-11) were firstly isolated from the . E. kansui. The chemotaxonomic significance of these compounds was summarized. © 2012 Elsevier Ltd. Source

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