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Shang P.H.,Key Laboratory of Phosphorus and Chemical Biology | Cheng C.M.,Key Laboratory of Phosphorus and Chemical Biology | Wang H.,Key Laboratory of Phosphorus and Chemical Biology | Zheng H.C.,Key Laboratory of Phosphorus and Chemical Biology | Zhao Y.F.,Key Laboratory of Phosphorus and Chemical Biology
Chinese Chemical Letters | Year: 2010

An efficient and novel method for synthesizing 3′,5′-dithio-2′-deoxyguanosine was described. In this method normal guanosine was used as the starting material. A very efficient procedure was used to synthesize 2́-O-tosylguanosine 1, which used 0.1 eq. DBTO instead of 2 eq. 1 was treated with LTBH to give 9-(2-deoxy-β-d-threo-pentofuranosyl)guanine 2. 2 could be easily turned to the target compound. © 2009 Chang Mei Cheng. Source

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