Time filter

Source Type

Nie X.,CAS National Center for Nanoscience and Technology | Zhang J.,CAS National Center for Nanoscience and Technology | Zhang J.,Key Laboratory of Pesticide Chemistry and Application | Xu Q.,CAS National Center for Nanoscience and Technology | And 4 more authors.
Journal of Materials Chemistry B | Year: 2014

In this paper, we report a novel targeting drug delivery system, obtained using an amphiphilic chitosan-co-(d,l-lactide)/1,2-dipalmitoyl-sn-glycero-3- phosphoethanolamine copolymer (CS-co-PLA/DPPE) with the modification of an iRGD (CRGDKGPDC) peptide as the targeting module. Hydrophilic doxorubicin (DOX) was encapsulated and cell experiments were carried out to evaluate the anti-tumor efficacy of DOX-loaded nanoparticles (NPs) in vitro. Characterization data showed a favorable size distribution, high encapsulation efficiency and a pH-dependent release profile for the synthesized NPs. A cytotoxicity assay revealed the higher inhibitory effect of DOX-iRGD-NPs especially in cell lines with an abundant expression of αvβ3 integrin receptors. An increased cellular uptake of DOX-iRGD-NPs was observed and further confirmed to be a consequence of a specific endocytosis pathway mediated by ligand-receptor interactions. Visualization of the intracellular trafficking showed different distributions of DOX when delivered using DOX-NPs and DOX-iRGD-NPs, proving the targeting effect of iRGD. With the help of the iRGD targeting peptide, a chemotherapeutic drug can be delivered specifically to the cancer and endothelial cells expressing αvβ3 integrin receptors to achieve an enhanced anti-tumor efficacy and controlled drug release. © the Partner Organisations 2014.


Hou C.-J.,Dalian Polytechnic University | Hou C.-J.,Key Laboratory of Pesticide Chemistry and Application | Guo W.-L.,Dalian Polytechnic University | Liu X.-N.,Dalian Polytechnic University | Yang D.-W.,Dalian Polytechnic University
Heterocyclic Communications | Year: 2011

Efficient synthetic routes to the title compounds 2-amino-5-chloro-3- pyridinecarboxaldehyde (1a) and 5-amino-2-chloro-4-pyridinecarboxaldehyde (1b) are reported. Both compounds are important substrates in the synthesis of naph-thyridine derivatives. Copyright © by Walter de Gruyter Berlin Boston.


Liu G.,Harbin Institute of Technology | Liu G.,Chinese Academy of Agricultural Sciences | Liu G.,Key Laboratory of Pesticide Chemistry and Application | Wang S.,Chinese Academy of Agricultural Sciences | And 10 more authors.
Analytical Methods | Year: 2016

A simple and sensitive colorimetric assay for the determination of atrazine in rice samples using cysteamine-gold nanoparticles (AuNPs) after solid phase extraction has been developed. The approach exploited the benefits of a robust sample pretreatment scheme with a rapid and sensitive colorimetric sensing strategy based on cysteamine-AuNPs. As a result of the hydrogen bonding between atrazine and cysteamine, cysteamine-AuNPs were induced to aggregate with an accompanying distinct color change from wine red to blue. The color change was monitored by UV-vis spectrophotometry or with the naked eye. The difference of the absorbance value at 523 nm was linearly related to the atrazine concentration over the range 0.033 to 6.67 μg g-1, and the limit of detection (S/N = 3) was 0.0165 μg g-1. The spiked rice samples were extracted and purified using Oasis HLB cartridges and satisfactory recoveries (83.23-91.65%) were realized. © The Royal Society of Chemistry 2016.


Liu G.,Harbin Institute of Technology | Liu G.,Chinese Academy of Agricultural Sciences | Liu G.,Key Laboratory of Pesticide Chemistry and Application | Yang X.,Harbin Institute of Technology | And 22 more authors.
Microchimica Acta | Year: 2015

We report on a method for the determination of the herbicide atrazine in tap water samples using melamine-modified gold nanoparticles (Mel-AuNPs). If a solution containing atrazine is added to a solution of such NPs, a color change occurs from wine-red to blue. This is due to a transition from monodisperse to aggregated Mel-AuNPs and caused by strong hydrogen bonding between atrazine and melamine. The color change can be monitored by a UV–vis spectrophotometer or with bare eyes. The ratio of the absorbances at 640 and 523 nm is linearly related to the logarithm of the atrazine concentration in the 0.165 to 16.5 μM range, and (with different slope) in the 16.5 μM to 330 μM range. The detection limit of atrazine is as low as 16.5 nM (S/N = 3). The method was successfully applied to the determination of atrazine in spiked tap water and gave recoveries that ranged from 72.5 % to 102.3 %. © 2015, Springer-Verlag Wien.

Loading Key Laboratory of Pesticide Chemistry and Application collaborators
Loading Key Laboratory of Pesticide Chemistry and Application collaborators