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Chen D.,Key Laboratory of Original New Drugs Design | Zhai X.,Key Laboratory of Original New Drugs Design | Yuan Q.H.,Key Laboratory of Original New Drugs Design | Luo J.,Key Laboratory of Original New Drugs Design | And 2 more authors.
Chinese Chemical Letters | Year: 2010

A series of 1H-benzimidazol-5-ol derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in HepG2.2.15 cells. Half of the tested compounds were found to be potent against HBsAg secretion with IC50 values less than 100μmol/L. Compounds 14c, 14d, and 14e showed significant inhibitory activity to the viral antigen HBeAg. © 2010 Ping Gong.

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