Key Laboratory of Optoelectronic Science and Technology for Medicine

Fujian, China

Key Laboratory of Optoelectronic Science and Technology for Medicine

Fujian, China

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Wu S.,Fujian Normal University | Wu S.,Key Laboratory of Photonics Technology | Wu S.,Key Laboratory of OptoElectronic Science and Technology for Medicine | Li H.,Fujian Normal University | And 14 more authors.
Journal of Biomedical Optics | Year: 2011

Multiphoton microscopy was employed for monitoring the structure changes of mouse dermis collagen in the intrinsic- or the extrinsic-age-related processes in vivo. The characteristics of textures in different aging skins were uncovered by fast Fourier transform in which the orientation index and bundle packing of collagen were quantitatively analyzed. Some significant differences in collagen-related changes are found in different aging skins, which can be good indicators for the statuses of aging skins. The results are valuable to the study of aging skin and also of interest to biomedical photonics. © 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).


Chen J.,Key Laboratory of Optoelectronic Science and Technology for Medicine | Chen J.,Fujian Normal University | Chen X.,Key Laboratory of Optoelectronic Science and Technology for Medicine | Chen X.,Fujian Normal University | And 8 more authors.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2014

Stimulated emission depletion (STED) optical nanoscopy can achieve super-resolution fluorescence imaging, by suppressing fluorescence on the peripheral of excitation center with a 0-2pi spiral phase plate. Previously, the STED intensity distribution at the focal plane and the derived expression of resolution are generally analytical described by vectorial integral. To overcome the complex and multifarious of the vectorial calculation, we proposed scalar integral method and used the Collins-Huygens integral to analytically describe the peak intensity, the central intensity of the doughnut spot and the resolution of STED nanoscopy. We verified our method by comparing our results with vector theory. And we found it agreed well with vectorial theory under the high STED power, which was commonly used experimental condition for high resolution. Our method provides a fast and convenient way to evaluate the performance of STED with spiral phase modulation. © 2014 SPIE.


Xie W.,Key Laboratory of Optoelectronic Science and Technology for Medicine | Xie W.,Fujian Normal University | Xie W.,Fujian Provincial Key Laboratory of Photonic Technology | Zeng Z.,Key Laboratory of Optoelectronic Science and Technology for Medicine | And 12 more authors.
Zhongguo Jiguang/Chinese Journal of Lasers | Year: 2012

Signal attenuation is highly concerned in many research fields. Imaging quality and depth in photoacoustic (PA) imaging system are often limited by the attenuation of PA signal. The PA signal attenuation is induced by many factors in PA imaging system. The factors leading to the signal attenuation and its characteristics are discussed based on tissue optics, acoustic transport and detection in a long-focal-zone PA imaging system. Considering to recover the PA signal from optical to ultrasonic attenuation, a method to compensate the detected PA signals is presented. The proposed method is evaluated by simulant sample and employed to image a thyroid tissue in vitro. The experimental results demonstrate that the method could be used to recover the PA signal and to improve the imaging depth and quality in the PA system.


Li Z.,Fujian Normal University | Li Z.,Key Laboratory of Optoelectronic Science and Technology for Medicine | Li Z.,Fujian Provincial Key Laboratory of Photonic Technology | Chen H.,Fujian Provincial Hospital | And 7 more authors.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2011

We explore the feasibility of using photoacoustic imaging based on a focused transducer to characterizing acute myocardial ischemia at different stage. In this study, we blocked rat left anterior coronary descending artery (LAD) to induce the acute myocardial ischemia. The results show that the intensity and areas of photoacoustic images of myocardial decrease with the LAD time increasing, which suggests that photoacoustic imaging has a potential for diagnosis of acute myocardial ischemia. © 2011 SPIE.


Xie W.,Key Laboratory of OptoElectronic Science and Technology for Medicine | Xie W.,Fujian Provincial Key Laboratory of Photonic Technology | Xie W.,Fujian Normal University | Li H.,Key Laboratory of OptoElectronic Science and Technology for Medicine | And 11 more authors.
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2010

Photoacoustic imaging is a promising technique in practical medicine to image biological tissue's function and diagnose internal organs. In this paper, a new photoacoustic imaging modality for imaging internal organs was presented. A laser which wavelength is tunable was coupled into a multimode optical fiber. And the fiber was inserted into the inner tract of the samples to deliver light for exciting photoacoustic signals. The outgoing PA signal was detected by a focal ultrasound transducer with long focal length which was placed on the surface of the samples. By transducer scanning, we obtained a 2D cross-section photoacoustic image. Finally, we evaluate this system's performance and demonstrate its capabilities by imaging phantoms with complex structure. © 2010 SPIE.


Wu S.,Key Laboratory of OptoElectronic Science and Technology for Medicine | Peng Y.,Key Laboratory of OptoElectronic Science and Technology for Medicine | Hu L.,Key Laboratory of OptoElectronic Science and Technology for Medicine | Zhang X.,Key Laboratory of OptoElectronic Science and Technology for Medicine | Li H.,Key Laboratory of OptoElectronic Science and Technology for Medicine
Journal of Physics: Conference Series | Year: 2016

Second harmonic generation microscopy (SHGM) was used to monitor the process of chronological aging skin in vivo. The collagen structures of mice model with different ages were obtained using SHGM. Then, texture feature with contrast, correlation and entropy were extracted and analysed using the grey level co-occurrence matrix. At last, the neural network tool of Matlab was applied to train the texture of collagen in different statues during the aging process. And the simulation of mice collagen texture was carried out. The results indicated that the classification accuracy reach 85%. Results demonstrated that the proposed approach effectively detected the target object in the collagen texture image during the chronological aging process and the analysis tool based on neural network applied the skin of classification and feature extraction method is feasible.


Weng C.,Key Laboratory of OptoElectronic Science and Technology for Medicine
Physica B: Condensed Matter | Year: 2010

This paper shows that the imaging depth of pulsed ultrasound-modulated optical imaging can be improved by reducing the duration and increasing the peak value of ultrasound pulse. © 2009 Elsevier B.V. All rights reserved.

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