Key Laboratory of New Drug Research and Clinical Pharmacy

Tongshan, China

Key Laboratory of New Drug Research and Clinical Pharmacy

Tongshan, China
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Yang Y.,Key Laboratory of New Drug Research and Clinical Pharmacy | Yang Y.,Xuzhou Medical College | Wang Q.,Key Laboratory of New Drug Research and Clinical Pharmacy | Wang Q.,Xuzhou Medical College | And 5 more authors.
Latin American Journal of Pharmacy | Year: 2016

The objective of the present work involves preparation, characterization, cellular uptake and pharmacokinetics of ligustrazine-loaded stealth liposomes (LTSL). LTSL had an average particle size of 112.2 ± 2.4 nm with a zeta potential of -21 ± 1.1 mV, and encapsulation efficiency of 83.5 ± 2.1%. In vitro release study showed a sustained release of ligustrazine (LT) from LTSL in accordance with the Higuchi equation. Phagocytosis tests showed significant differences between LTSL and LTL (ligustrazine-loaded liposomes) and demonstrated that LTSL could decrease opsonization with serum proteins and uptake with phagocyte cells. Pharmacokinetic test indicated that areas under the plasma level-time curve (AUC) of LTSL was 15-fold higher than that of free LT, half-life of LTSL was prolonged by 7.5 folds than that of free LT. Compare to free LT, clearance (CL) of LTSL was decreased notably. LTSL had longer circulating time in blood with mean residence time (MRT) of 5.286 h compared to free LT. LTSL could be a good formulation of LT for clinical application. © 2015, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.


Liu L.,Xuzhou Medical College | Liu L.,Key Laboratory of New Drug Research and Clinical Pharmacy | Mou J.,Key Laboratory of New Drug Research and Clinical Pharmacy | Zheng Y.,Key Laboratory of New Drug Research and Clinical Pharmacy | And 3 more authors.
Letters in Drug Design and Discovery | Year: 2015

A new complex [Cu(D-glu)(phen)(H2O)]·NO3·2H2O 1 (D-glu = D-glutamic acid, phen = 1,10-phenanthroline) was synthesized and identified by IR spectroscopy and single-crystal X-ray diffraction. Fluorescence studies showed that 1 exhibited stronger intercalative interaction to CT-DNA as compared to known complex [Cu(L-glu)(phen)(H2O)]·NO3·2H2O 2. Both complexes inhibited the growth of MCF-7 cells with the IC50 values of 0.141 μmol·L-1 and 0.126 μmol·L-1 for complex 1 and 2, respectively. The complexes were 20 times more active than the amino acid - free complex [Cu(phen)(H2O)2(NO3)] · NO3 3. © 2015 Bentham Science Publishers.

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