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Liu L.,Xuzhou Medical College | Liu L.,Key Laboratory of New Drug Research and Clinical Pharmacy | Mou J.,Key Laboratory of New Drug Research and Clinical Pharmacy | Zheng Y.,Key Laboratory of New Drug Research and Clinical Pharmacy | And 3 more authors.
Letters in Drug Design and Discovery | Year: 2015

A new complex [Cu(D-glu)(phen)(H2O)]·NO3·2H2O 1 (D-glu = D-glutamic acid, phen = 1,10-phenanthroline) was synthesized and identified by IR spectroscopy and single-crystal X-ray diffraction. Fluorescence studies showed that 1 exhibited stronger intercalative interaction to CT-DNA as compared to known complex [Cu(L-glu)(phen)(H2O)]·NO3·2H2O 2. Both complexes inhibited the growth of MCF-7 cells with the IC50 values of 0.141 μmol·L-1 and 0.126 μmol·L-1 for complex 1 and 2, respectively. The complexes were 20 times more active than the amino acid - free complex [Cu(phen)(H2O)2(NO3)] · NO3 3. © 2015 Bentham Science Publishers. Source

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