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Zhang W.,Yanbian University | Han R.-B.,Yanbian University | Han R.-B.,Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules | Zhang W.-B.,Yanbian University | And 2 more authors.
Journal of Heterocyclic Chemistry | Year: 2013

Eight new benzotriazoloazepine derivatives have been synthesized starting from 7-methoxy-2,3,4,5-tetrahydro-1H-2-benzo[c]azepin-1-one. The compounds 2a-c have been synthesized by the reaction of 7-methoxy-2,3,4,5-tetrahydro-1H-2- benzo[c]azepin-1-thione with various hydrazides. Reaction of 5 with hydrazine hydrate, followed by treatment of the resultant hydrazone with formic acid, gave corresponding 9-alkoxy-6,7-dihydro-5H-benzo[c][1,2,4]triazolo[4,3-a]azepine(6a, b). Cyclization of 5 with methyl carbazate gave 9-alkoxy-6,7-dihydro-2H-benzo[c] [1,2,4]triazolo[4,3-a]azepin-3(5H)-one (7a-c). The structures of the compounds were confirmed by their elemental analysis and spectral data. Their anticonvulsant activities have been initially screened. © 2013 HeteroCorporation.


Jin D.-C.,Yanbian University | Zhang W.-B.,Yanbian University | Piao F.-Y.,Yanbian University | Han R.-B.,Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules
Acta Crystallographica Section E: Structure Reports Online | Year: 2011

In the title mol-ecule, C 18H 16ClN 3O 2, the seven-membered ring adopts an envelope conformation with the flap atom deviating by 0.801 (5) Å from the mean plane formed by the remaining non-H atoms. Inter-molecular N - H⋯O hydrogen bonds link the mol-ecules into centrosymmetric dimers. The crystal packing also exhibits weak inter-molecular C - H⋯N hydrogen bonds and π-π inter-actions with a short distance of 3.734 (3) Å between the centroids of the aromatic rings of neighbouring mol-ecules. © Jin et al. 2011.


Qu B.,Yanbian University | Li W.,Yanbian University | Chen Y.,Yanbian University | Chen Y.,Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules | Liu J.,Yanbian University
International Journal of Sustainable Development and World Ecology | Year: 2011

Under Chinese culture it is believed that herbal medicine is always safe and wild food is always healthy. Generally, the rarer a plant, the higher its value. The booming economy in China has promoted tourism development in wilderness areas and wild medicinal and food plants are part of the attraction to tourists. Conflicts between wild plant exploitation and protection have emerged in many parts of China, such as Changbai Mountain. Changbai Mountain supports numerous medicinal and food plants but many have become rare and endangered. This paper numerically evaluates 30 plant species that have relatively high conservation value for each type (medicinal, ornamental and food), and briefly describes the uses of four to five top ranked species per type that need more protection on Changbai Mountain. This paper also addresses some tree species with important timber values on Changbai Mountain. Over 90% of China's medicinal, ornamental and food plant species, as well as valuable timber trees are found in the conifer-broadleaf mixed forest zone across the boundary of Changbai Mountain Nature Reserve. It is a major challenge to protect the native biodiversity of mixed forest on Changbai Mountain and more efforts need to be made to protect rare and endangered plant species with high economic value. © 2011 Taylor & Francis.


Zhu W.H.,Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules | Zhu W.H.,Yanbian University | Miao C.Y.,The First Middle School in Linyi | Zheng X.J.,Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules | And 4 more authors.
Shengtai Xuebao/ Acta Ecologica Sinica | Year: 2014

Wetlands, forests and oceans form the three global ecosystems. Wetlands are the natural integration of aquatic and semi-aquatic creatures in a wet environment. Wetlands are an important natural resource and one of the most important environments for human survival. They not only offer the raw materials for human life and human production but also play an important role in ameliorating weather conditions, flood storage, and the control and reduction of environmental pollution. Wetlands have thus been called the "kidney of the earth". Global and regional problems such as environmental pollution, soil erosion and so on, have become more and more serious with the rapid development of human society. These problems create a serious threat to society, economic, development and perhaps even human survival. People are discovering it is not military or political activity which threatens to restrict economic development, but ecological crises which are creating long term effects. Also, people are gradually realizing that ecological stability is critical to both broad scale ecosystem integrity and guaranteeing sustainable development. It is the region or country other ecological safety of the carrier and the foundation. The development of human society depends on creating sustainable development with a system which secures the survival of ecological systems. Therefore, the study of ecological sustainability has become a field of concern. Tumen river is one of the key international rivers in China. The region has already entered into multinational cooperation in developmental stages with the Chinese economy rising rapidly. The environment has been getting interfered with and destroyed in different degrees. This study can provide a scientific basis for sustainable development of ecological environment of the Tumen river basin. In this study, we used the Tumen river watershed wetland ecological security for the purpose built wetland ecology safety evaluation system based on Pressure-Status-Response (PSR) concept model, and got landscape dates of 1976,1990,2000 and 2010 by using 3S technology. We used experts' evaluation index combined with AHP evaluation to give the weight and got the final comprehensive evaluation in the use of the logistical growth curve model for each index based on the assessment of a single index. The study finally got the ecological secure values that were respectively 0.650,0.620 in 1976 and 1990, the ecological system was in a safe state; the ecological secure values were respectively 0.536 and 0.454 in 2000 and 2010, which shows that the ecological system was in a state of early warning. The wetland ecological system should be immediately protected. Based on this, we used the grey prediction model to build a wetland ecological safety prediction model and did accuracy testing for the model. The Simulation error, correlation and the mean square error ratio, and the small error probability were primary concerns but the model accuracy was high enough for the Tumen river wetland ecological safety prediction. Finally this study made a prediction for the Tumen river basin wetland ecological safety for 40 years, the results were respectively 0.3903, 0.3345, 0.2866 and 0.2456. The wetland ecological system was in a moderate warning state and the trend of the situation continued to become more severe. Ecological security threat is very serious and this area needs more protection and management for the wetland ecosystem to survive.


Zhu W.H.,Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules | Zhu W.H.,Yanbian University | Cao G.L.,Yanbian University | Li Y.,Yanbian Environmental Protection Agency | And 3 more authors.
Shengtai Xuebao/ Acta Ecologica Sinica | Year: 2014

Rivers Play a Key role in Ecosystems and Society, and THEY Provide a range of Ecosystem Functions SUCH as Shelter and Food Source for an array of Biological species, aid in flood Management and Ecological Refuge Development Socially, rivers Accommodate Communities by PROVIDING a medium for transport, recreation, tourism, worship, ecosystem services and a place to experience the serenity of nature Tumen River is an international river which located in the national boundaries of China, North Korea and Russia. With the three countries have different management and policies, it has been being seriously destroyed by various human activities including contaminant discharge, damming, solidifying riverside, destroying vegetation in the riparian zone and etc., resulting in deterioration of water environment, degradation of biological communities and riverbed atrophying It brings bad affection on the social and economic development of Tumen River Basin area which also affects and restricts the regional economic development. Therefore, the restoration and maintenance of "healthy" river ecosystems have become important objective of river management. In this paper, we summarize the current health conditions of national and international river ecosystem, and establish an evaluation system for ecological health, which is suitable for the river ecosystem in Tumen River Basin. The system includes an objective layer, a rule layer with 5 factors and an index layer with 22 defined indexes. The objective layer generalized to the river health highly, reflecting the total level of the healthy condition of river by the river health index (RHI).The rule layers, which consider the river hydrology, river morphology, riparian zone, water quality parameters, aquatic organisms, reflected the river health attribute and level from different sides. The index layer included 22 qualitative and quantitative evaluation indicators. In this system, a health assessment index for river ecosystem is constructed based on five health stage criteria: primary health (81


Hu B.,Hong Kong Polytechnic University | Yao Z.-P.,Hong Kong Polytechnic University | Yao Z.-P.,Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules
Analytical Chemistry | Year: 2016

Proteins are important substances in living organisms and characterization of proteins is an indispensible part for protein study. Analysis of proteins using electrospray ionization-mass spectrometry (ESI-MS) with porous substrates was investigated in this study. The results revealed that the ionization process had two stages. At the first stage, mobility and resulting spectra of proteins were similar to those obtained with conventional capillary-based ESI-MS. At the second stage, hydrophobic-hydrophobic interactions between proteins and the tip surfaces played an important role in mobility and detectability of protein ions, which were size and shape dependent, and a linear relationship could be found between the peak area of selected ion chromatogram and the cross section of protein ions. Preparative separation of proteins could be achieved by collecting the proteins remained on the porous substrates. These results led us to propose that electrospray ionization from porous substrates offer a potential approach for analysis of proteins and investigation of protein structures and conformations. © 2016 American Chemical Society.


Hou J.,Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules | Wu X.,Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules
Synthetic Metals | Year: 2011

This paper reported two stilbazolium derivatives with differdent counter-anion (OPVBr and OPVOH). The two stilbazolium derivatives have a quadrupoles (A-π-D-π-A) structure, in which pyridinium cation was used as electron-accept group and dibutoxy benzene as electron-donor group. Their linear optical properties were investigated through UV-vis and fluorescence spectral analysis. Two-photon laser induced fluorescence measurements have shown that OPVOH have a small TPA cross section (35 GM), while OPVBr have a large TPA cross section (904 GM). The TPA cross-sections value of OPVBr is increased with the concentration increasing due to the enhancement of intermolecular π-π stacking interaction. © 2011 Elsevier B.V. All rights reserved.


Qiu J.-B.,Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules | Yin B.-Z.,Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules
Acta Crystallographica Section E: Structure Reports Online | Year: 2011

The title compound, C 22H 30N 4O 2, has a crystallographic inversion center located at the mid-point of the N-N single bond. Apart from the four ethyl C atoms, the non-H atoms are nearly coplanar with a mean deviation of 0.0596 (2) Å. An intramolecular O-H⋯N hydrogen bond occurs. In the crystal, weak intermolecular C-H⋯O hydrogen bonds link the molecules into layers parallel to (100).


Zhang L.-J.,Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules | Yin B.-Z.,Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules
Acta Crystallographica Section E: Structure Reports Online | Year: 2011

The asymmetric unit of the title compound, C14H 17N3O3, contains two independent molecules with different conformations of the ethyl groups. In the crystal, intermolecular N-H⋯O hydrogen bonds link the molecules into ribbons extending along the a axis.


Hou J.,Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules | Wang L.-Y.,Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules | Li D.-H.,Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules | Wu X.,Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules
Tetrahedron Letters | Year: 2011

A rigid conjugated pyridinylthiazole derivative (1) and two bithiazole derivatives with similar structures (2, 3) were synthesized and characterized. Their optical properties were investigated through spectral analysis. By applying the three compounds to Cu2+ ions detection, it was shown that compound 1 could be employed as a selective and sensitive Cu2+ ions fluorescent chemosensor. For aqueous assay, the nanoparticles of compound 1 were prepared in aqueous media. Compared to the monomer, 1 nanoparticles were more fluorescence sensitive to Cu2+ ions. Its binding mode with Cu2+ ions was correlated well with Langmuir equation. Compound 1 nanoparticles exhibit a dynamic working range for Cu2+ ions from 0.02 to 0.50 μM with a detection limit of 10 nM. The proposed chemosensor has been used for the direct measurement of Cu2+ content in drinking water samples with satisfying results. © 2011 Elsevier Ltd. All rights reserved.

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