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Shanghai, China

Hong J.,Xiamen University | Hong J.,Fudan University | Hong J.,Massachusetts Eye and Ear Infirmary | Yu Z.,Fudan University | And 8 more authors.
Optometry and Vision Science | Year: 2015

Purpose. To compare the postoperative measurements of intraocular pressure (IOP) using the Corvis ST Tonometer (CST), ocular response analyzer (ORA), and Goldmann applanation tonometry (GAT) in eyes undergoing laser in situ keratomileusis (LASIK), as well as to analyze the relationship between the corneal biomechanical parameters of the CST and the ORA. Methods. Fifty participants who had undergone LASIK to treat myopia in the previous 3 months were enrolled. Postoperative IOP measurements of these participants were obtained using the CST, ORA (corneal-compensated IOP [IOPcc], Goldmanncorrelated IOP [IOPg]), and GAT. Device agreement was calculated by Bland-Altman analysis. The metrics of corneal biomechanical properties were recorded using the ORA and the CST. Corneal biomechanical parameters were compared. Results. The Bland-Altman analysis revealed a significant bias between CST and GAT, between CST and IOPcc, and between CSTand IOPg of 3.4, 1.0, and 3.8,mmHg, respectively, with 95% limits of agreement ofj0.7 to 7.5mmHg,j2.1 to 4.2 mm Hg, and j0.4 to 8.0 mm Hg. The ORA-derived IOP measurements, CST-derived IOP, and GAT IOP values showed good correlation with each other. The CST IOP and IOPcc were higher than the GAT IOP (all p < 0.05), whereas IOPg did not differ from the GAT IOP readings. Ocular response analyzerYderived corneal biomechanical parameters (corneal hysteresis and the corneal resistance factor) showed significant correlations with CST-derived parameters, including the maximum deformation amplitude at the corneal apex and the time from start until the first applanation. Conclusions. The CST offers an alternative method for measuring postoperative IOP in LASIK patients, and it appears to obtain higher IOP values than other tonometry techniques. The technique may facilitate the investigation of corneal biomechanical property changes in LASIK-treated eyes. © 2015 American Academy of Optometry.


Lin T.,Fudan University | Lin T.,Key Laboratory of Myopia | Gong L.,Fudan University | Gong L.,Key Laboratory of Myopia
Medicine (United States) | Year: 2016

The aim of the study was to evaluate the morphological changes of meibomian glands (MGs) in primary blepharospasm (PBS) by in vivo laser scanning confocal microscopy (LSCM) and to investigate the correlations between clinical data of PBS and LSCM parameters of MGs. This prospective and case-control study recruited 30 consecutive PBS patients and 30 age-and gendermatched healthy controls. After questionnaire assessments of ocular surface disease index (OSDI), Jankovic rating scale, and blepharospasm disability index, all subjects underwent blink rate evaluation, tear film break-up time (TBUT), corneal fluorescein staining (CFS), Schirmer test, MG expressibility, meibum quality, MG dropout, and LSCM examination of the MGs. The main LSCM outcomes included the mean MG acinar area and density, orifice diameter, meibum secretion reflectivity, acinar irregularity, and inhomogeneity of interstice and acinar wall. The PBS patients had significantly higher blink rate, higher OSDI and CFS scores, lower TBUT and Schirmer test value, and worse MG expressibility than the controls (All P<0.05), whereas meibum quality showed no difference (P>0.05). The PBS patients showed lower values of MG acinar area, orifice diameter and meibum secretion reflectivity, and higher scores of acinar irregularity and inhomogeneity of interstices than the controls (All P<0.05). For the PBS patients, the severity of blepharospasm evaluated by JCR scale was strong correlated with MG acinar area (P<0.001), orifice diameter (P= 0.002), meibum secretion reflectivity (P=0.002), and MG acinar irregularity (P=0.013). The MG expressibility was significantly correlated to MG acinar area (P=0.039), orifice diameter (P<0.001), and MG acinar irregularity (P=0.014). The OSDI score was moderate correlated with MG acinar irregularity (P=0.016), whereas the TBUT value was positively correlated with MG acinar area (P=0.045) and negatively correlated to MG acinar irregularity (P=0.016). The CFS score was negatively correlated to MG orifice diameter (P=0.008). The LSCM provided a noninvasive tool for in vivo histopathologic studies of MGs in PBS patients. The excessive constriction of lid muscles closely related to MG morphological alterations of PBS, which offered a new research approach to interpret the interactional mechanism between dry eye and PBS. © 2016 Wolters Kluwer Health, Inc. All rights reserved.


Zhu X.-J.,Fudan University | Wolff D.,Key Laboratory of Myopia | Zhang K.-K.,Fudan University | He W.-W.,Fudan University | And 3 more authors.
Investigative Ophthalmology and Visual Science | Year: 2015

PURPOSE. The purpose of this study was to assess the inflammatory status of the aqueous humor in the fellow eye after uneventful cataract surgery in the first eye. METHODS. At the screening stage, aqueous humor samples from 15 first-eye and 15 second-eye cataract patients were collected just before cataract surgery and assayed using human cytokine antibody array. Screened cytokines were then verified using a suspension array system with aqueous humor samples obtained from 35 first-eye and 36 second-eye cataract patients. RESULTS. The cytokine antibody array revealed that interleukin-1 receptor antagonist (Il-1ra) and macrophage inflammatory protein (MIP)-1a and MIP-1b were expressed at high levels in first-eye patients and were lower in second-eye patients, whereas opposite trends were found for monocyte chemoattractant protein 1 (MCP-1) and for regulated on activation, normal T expressed and secreted (RANTES) (all, P < 0.05, Student’s t-test). However, only MCP-1 and IL-1ra were significantly different between the two groups after Bonferroni correction (both P < 0.00125). In the replication stage, the suspension cytokine array revealed that only MCP-1 expression was significantly greater in the aqueous humor of second-eye patients than in that of first-eye patients (P = 0.0067, Student’s t-test). CONCLUSIONS. This study revealed that expression of MCP-1, a pain-related inflammatory chemokine, was significantly increased in aqueous humor in the contralateral eye after firsteye cataract surgery. This suggests there may be a sympathetic ophthalmic type uveitis in the contralateral eye after first-eye cataract surgery and that may help to explain why second-eye phacoemulsification is often more painful. © 2015 The Association for Research in Vision and Ophthalmology, Inc.


Zhou X.-Y.,Fudan University | Wang L.,Fudan University | Zhou X.-T.,Fudan University | Zhou X.-T.,Key Laboratory of Myopia | And 2 more authors.
Eye (Basingstoke) | Year: 2015

Purpose: The aim of this study was to investigate the wavefront aberration changes in human eyes caused by a gradient of increasing accommodation stimuli. Design: This is a prospective, single-site study. Methods: Healthy volunteers (n=22) aged 18-28 years whose refraction states were emmetropia or mild myopia, with astigmatism <1 diopter (D), were included in this study. After dilating the right pupil with 0.5% phenylephrine drops, the wavefront aberration of the right eye was measured continuously either without or with 1, 2, 3, 4, 5, or 6D accommodation stimuli (WFA1000B psychophysical aberrometer). The root mean square (RMS) values of the total wavefront aberrations, higher-order aberrations, and 35 individual Zernike aberrations under different accommodation stimuli were calculated and compared. Results: The average induced accommodations using 1, 2, 3, 4, 5, or 6D accommodation stimuli were 0.848, 1.626, 2.375, 3.249, 4.181, or 5.085 D, respectively. The RMS of total wavefront aberrations, as well as higher-order aberrations, showed no significant effects with 1-3 D accommodation stimuli, but increased significantly under 4, 5, and 6 D accommodation stimuli compared with relaxed accommodation. Zernike coefficients of Z0 4 significantly decreased with increasing levels of accommodation. Conclusion: Higher-order wavefront aberrations in human eyes changed with increased accommodation. These results are consistent with Schachar's accommodation theory. © 2015 Macmillan Publishers Limited.


Liu R.,Fudan University | Liu R.,Key Laboratory of Myopia | Qian Y.-F.,Fudan University | Qian Y.-F.,Key Laboratory of Myopia | And 10 more authors.
Experimental Eye Research | Year: 2011

We investigated whether different monochromatic lights with similar luminance or identical light quantum number produce predictable changes in refractive state and eye growth in early eye development in guinea pigs. In experiment I, three groups of guinea pigs (two weeks of age, n=18 in each group) were reared for 12 weeks under LED lighting of 430. nm (short-wavelength light, SL), 530. nm (middle-wavelength light, ML), and broad-band light (BL). The lighting conditions were set to provide equal levels of luminance. All animals underwent refraction and biometric measurements every 2 weeks. In experiment II, the lighting conditions were set at equal quantum number and another three groups of guinea pigs were raised and tested for 20 weeks. In experiment I, compared to the BL group, refraction of the ML group was less hyperopic (P<0.001) with a faster vitreous extension (P<0.001), while the SL group was more hyperopic with a slower vitreous elongation (P<0.001). The mean difference in refraction between the SL and ML groups reached about 4.5 D at maximum. The refractive changes and eye growth in experiment II were very similar to experiment I during the first 12 weeks, but the difference in refraction between the SL and ML groups reached 6.05 D after 20 weeks of treatment, which was greater than the longitudinal chromatic aberration (approximately 1.5 D) in the guinea pigs eyes. The results suggest that the guinea pigs' eyes overcompensated in response to narrow-band light, which resulted in an exaggerated and inaccurate refractive growth. © 2011 Elsevier Ltd.

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