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Zhao Y.,Xi'an Jiaotong University | Zhao Y.,Key Laboratory of Molecular Cardiology of Shaanxi Province | Ma S.,Xi'an Jiaotong University | Ma S.,Key Laboratory of Molecular Cardiology of Shaanxi Province | And 8 more authors.
International Journal of Clinical and Experimental Pathology | Year: 2017

Background: Primary lymphomas of the heart are very rare, especially primary cardiac extranodal natural killer/T-cell Lymphoma. Primary cardiac natural killer/T-cell lymphoma has diversified symptoms and the diagnosis is difficult. Case presentation: We have reported a 35 year old man with palpitation, fever and increasing dyspnea. Transthoracic echocardiography was done and showed a large piece of mass. We resected the mass which was in the right atrium. Pathologic examination of removed cardiac tumor had reported as below: non Hodgkin-NK/T cell lymphoma. The patient received surgery, without chemotherapy, and was died on the 27th day after surgery of follow-up. Conclusion: This disease has a quick progression and a poor prognosis. Only surgery couldn't control primary cardiac natural killer/T-cell Lymphoma very well. Therefore, early detection is becoming more important.

Lv Y.-B.,Xi'an Jiaotong University | Lv Y.-B.,Key Laboratory of Molecular Cardiology of Shaanxi Province | Wang Y.,Xi'an Jiaotong University | Wang Y.,Key Laboratory of Molecular Cardiology of Shaanxi Province | And 14 more authors.
PLoS ONE | Year: 2016

Background/Aims: Two renalase single nucleotide polymorphisms (SNPs) rs2296545 and rs2576178 have been reported to be associated with the susceptibility to hypertension (HT). Given the inconsistent results, we conducted a meta-analysis to assess the association between these two SNPs and the risk of HT. Methods: Electronic databases were systematically searched to find relevant studies. Subgroup analysis was conducted according to the different concomitant diseases and ethnicities in the study population. Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated using fixed-effect or random-effect models. Results: A total of six case-control studies on rs2296545 and six studies on rs2576178 were included. In the combined analysis, results showed a significant association between SNP rs2296545 and risk of HT in all genetic models (dominant model CG+CC/GG: OR = 1.43, 95% CI = 1.24-1.65; recessive model CC/CG+GG: OR = 1.36, 95% CI = 1.09-1.69; codominant model CC/GG: OR = 1.63, 95% CI = 1.20-2.20, CG/GG: OR = 1.30, 95% CI = 1.12-1.52; allelic model C/G: OR = 1.29, 95% CI = 1.10-1.51). In subgroup analysis, we observed a significant association between rs2296545 and risk of essential HT. Although we did not observe an association between rs2576178 polymorphism and HT in the combined analysis, an increased risk was observed in the essential HT patients versus healthy controls (subgroup 1) analysis under the dominant, recessive, and codominant genetic models. Conclusions: Renalase gene rs2296545 polymorphism is significantly associated with increased risk of HT, whereas rs2576178 polymorphism may not be associated with the susceptibility to HT. © 2016 Lv et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Li X.,Xi'an Jiaotong University | Li X.,Key Laboratory of Molecular Cardiology of Shaanxi Province | Li X.,Ningxia Medical University | Wang T.,Xi'an Jiaotong University | And 9 more authors.
Journal of Biomedical Research | Year: 2011

Remodeling of ion channels is an important mechanism of arrhythmia induced by heart failure (HF). We investigated the expression of potassium channel encoding genes in the ventricles of rabbit established by volume-overload operation followed with pressure-overload. The reversible effect of these changes with bisoprolol was also evaluated. The HF group exhibited left ventricular enlargement, systolic dysfunction, prolongation of corrected QT interval (QTc), and increased plasma brain natriuretic peptide levels in the HF rabbits. Several potassium channel subunit encoding genes were consistently down-regulated in the HF rabbits. After bisoprolol treat-ment, heart function was improved significantly and QTc was shortened. Additionally, the mRNA expression of potassium channel subunit genes could be partially reversed. The down-regulated expression of potassium channel subunits Kv4.3, Kv1.4, KvLQT1, minK and Kir 2.1 may contribute to the prolongation of action potential duration in the heart of rabbits induced by volume combined with pressure overload HF. Bisoprolol could partially reverse these down-regulations and improve heart function. © 2011 The Editorial Board of Journal of Biomedical Research.

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