Key Laboratory of Microbial Metabolism

Shanghai, China

Key Laboratory of Microbial Metabolism

Shanghai, China
SEARCH FILTERS
Time filter
Source Type

Zhang W.-X.,East China University of Science and Technology | Zhong J.-J.,East China University of Science and Technology | Zhong J.-J.,Key Laboratory of Microbial Metabolism
Journal of Bioscience and Bioengineering | Year: 2010

Effects of oxygen concentration within 21-100% in gaseous phase on the morphology and ganoderic acids (GAs) production by Ganoderma lucidum in liquid static culture were studied. A higher oxygen concentration increased individual GAs production, and more spores and higher total GA content were obtained at an oxygen level of 80%. © 2009 The Society for Biotechnology, Japan.


Zhai D.D.,East China University of Science and Technology | Jin H.Z.,Shanghai JiaoTong University | Zhong J.J.,East China University of Science and Technology | Zhong J.J.,Key Laboratory of Microbial Metabolism
Chinese Chemical Letters | Year: 2010

A new sesquiterpene (Z)-7-acetoxy-methyl-11-methyl-3-methylenedodeca-1,6,10-triene (AMDT) was isolated and identified from the methanol extract of the hairy root culture of Artemisia annua. The structure of AMDT was determined based on the analysis of spectroscopic data, notably of the 2D NMR spectra. This new compound showed cytotoxicity against human tumor cell lines 95-D and HeLa with IC50 values of 27.08 and 20.12 μmol/L, respectively. © 2010 Jian Jiang Zhong.


Su J.-J.,Key Laboratory of Microbial Metabolism | Zhou Q.,Key Laboratory of Microbial Metabolism | Zhang H.-Y.,Key Laboratory of Microbial Metabolism | Li Y.-Q.,Key Laboratory of Microbial Metabolism | And 2 more authors.
Bioresource Technology | Year: 2010

Statistics based experimental designs were applied to optimize the culture medium components for enhancing phenazine-1-carboxylic acid (PCA) production by Pseudomonas sp. strain M18GQ, a gacA qscR double mutant of Pseudomonas sp. strain M18. The medium components, including soybean meal, glucose and corn steep liquor, had significant effects on PCA production based on a 25-1 fractional factorial design. The concentrations of these three significant factors were subsequently optimized using a central composite design. An optimum concentration of soybean meal 73.3 g/L, corn steep liquor 18.1 g/L, glucose 17.9 g/L, and ethanol 18.0 ml/L was obtained by response surface analysis. The predicted maximum PCA yield was as high as 4011.5 mg/L, and was confirmed by validation experiments. The double mutant M18GQ produced 4032.2 mg/L PCA, which was almost 2 to 3.3-fold that produced by either single mutant M18G and M18Q. The achieved production level is economically useful for industrial application. © 2010 Elsevier Ltd. All rights reserved.


Zou Y.-z.,Key Laboratory of Microbial Metabolism | Qi K.,East China University of Science and Technology | Chen X.,Key Laboratory of Microbial Metabolism | Miao X.-l.,Key Laboratory of Microbial Metabolism | Zhong J.-J.,Key Laboratory of Microbial Metabolism
Journal of Bioscience and Bioengineering | Year: 2010

Xylitol production from xylose by a self-isolated furfural and 5-hydroxymethyl furfural assimilating Pichia guilliermondii was studied under oxygen limitation. An extremely low initial volumetric oxygen transfer coefficient (0.075 h- 1) was found most favorable to the xylitol production with yield of 0.61 g g- 1. Related enzymes activities were also investigated and discussed. © 2009 The Society for Biotechnology, Japan.

Loading Key Laboratory of Microbial Metabolism collaborators
Loading Key Laboratory of Microbial Metabolism collaborators