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Chen X.-J.,Soochow University of China | Shen J.,Soochow University of China | Zhang G.-B.,Soochow University of China | Zhang G.-B.,Key Laboratory of Medicine and Clinical Immunology of Jiangsu Province | And 2 more authors.
Pathology and Oncology Research | Year: 2014

B7-H6, a novel member of the B7 family which binds to NKp30 to trigger antitumor NK cell cytotoxicity and cytokine secretion. Recently, B7-H family has been reported to be a negative regulator of the immune response in patients with gastric carcinoma. However, no reports have investigated the clinical significance of B7-H6 expression in human gastric cancer. We present the first study to the clinicopathological and prognostic value of B7-H6 in primary gastric tumors and adjacent non-tumor tissues at the protein level. Here we show that B7-H6 immunoreactivity was expressed in 6/60 (10%) gastric tumors and 8/43 (18.60%) adjacent non-tumor tissues. No statistical difference was found between B7-H6 expression and various prognostic factors; however, B7-H6-positive carcinomas were significantly associated with a higher differentiation (p=0.047). The survival analysis did not confirm the prognostic significance of B7-H6 expression in gastric cancer patients. Our data suggest that B7-H6, as detected by immunohistochemistry, is of limited value as a prognostic marker for gastric cancer. © Arányi Lajos Foundation 2013.

Li R.,Soochow University of China | Li R.,Key Laboratory of Medicine and Clinical Immunology of Jiangsu Province | Chen W.-C.,Soochow University of China | Chen W.-C.,Key Laboratory of Medicine and Clinical Immunology of Jiangsu Province | And 5 more authors.
Medicinal Chemistry Research | Year: 2010

The solvent extraction (SE) of garlic essential oil (Allium sativum) was studied. A multivariate study based on a four-factor, three-level Box-Behnken design (BBD) was used to evaluate the influence of four major variables affecting the performance of the SE of garlic essential oil. The yield and the composition of the essential oils from garlic obtained by SE were determined, and compared with those obtained by the supercritical fluid extraction (SFE). Statistical treatment of the results provided by the BBD revealed that the selected parameters, extraction time and extraction temperature, were significant. The essential oils were analyzed by gas chromatography-mass spectrometry (GC-MS). Major essential oil components were 3-vinyl-4H-1,2-dithiin (31.89%), diallyl trisulfide (13.31%), diallyl sulfide (2.22%), dially disulfide (6.87%), propyl allyl disulfide (13.89%), and dimethyl disulfide (7.05%). Compared with SFE, the yield of essential oil obtained by SE was slightly lower, but major essential oil components were quantitatively similar. Moreover, residual solvent in garlic essential oil was very low (<50 mg/kg). In addition, a significant increment in the ratio of CD4+/CD8 + in serum of gastric cancer rats was determined after administration of garlic essential oil. It can be concluded, that the SE method offers obvious advantages over SFE. Moreover, the results indicated that garlic essential oil may be useful for treatment of patients with inflammatory disease, e.g., gastric cancer. © 2009 Birkhäuser Boston.

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