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Yang L.-J.,Yunnan Nationalities University | Ma S.-X.,Yunnan Nationalities University | Zhou S.-Y.,Yunnan Nationalities University | Chen W.,Key Laboratory of Medicinal Chemistry for Natural Resource | And 3 more authors.
Carbohydrate Polymers | Year: 2013

The inclusion complexation behavior, characterization and binding ability of naringenin with β- cyclodextrin and its derivatives were investigated in both solution and the solid state by means of XRD, DSC, SEM, 1H and 2D NMR and UV-vis spectroscopy. The results showed that the water solubility and thermal stability of naringenin were obviously increased in the inclusion complex with cyclodextrins. This satisfactory water solubility and high thermal stability of the naringenin/CD complexes will be potentially useful for their application as herbal medicines or healthcare products. © 2013 Elsevier Ltd. All rights reserved. Source


Peng F.,Key Laboratory of Medicinal Chemistry for Natural Resource | Shao Z.,Key Laboratory of Medicinal Chemistry for Natural Resource | Shao Z.,Institute of Chemical Technology | Chan A.S.C.,Institute of Chemical Technology
Tetrahedron Asymmetry | Year: 2010

An unprecedented effect of the ligand-to-metal ratio on the stereofacial selection in the copper-catalyzed enantioselective addition of terminal alkynes to N-PMP-α-imino esters was observed. An excess of ligand was found not to be beneficial, on the contrary, an excess of copper was found to be beneficial. Moreover, both enantiomers of the alkynylation product were obtained with almost the same enantiomeric excess with the same chiral ligand by simply adjusting the ligand-to-metal ratio. The investigation of the mechanism demonstrated the presence of a positive nonlinear effect [(+)-NLE]. © 2010 Elsevier Ltd. All rights reserved. Source


Huang R.,Key Laboratory of Medicinal Chemistry for Natural Resource | Ding Z.-G.,Yunnan University | Long Y.-F.,Yunnan University | Zhao J.-Y.,Yunnan University | And 4 more authors.
Chemistry of Natural Compounds | Year: 2013

A new natural product named 7-O-methyl-8-chlorogenistein (1) was isolated together with eight known isoflavones, 8-chlorogenistein (2), kakkatin (3), 7-O-methyl genistein (4), genistein (5), daidzein (6), glycitin (7), genistin (8), and daidzin (9), from the metabolites of Streptomyces strain YIM GS3536, which was isolated from soil sample collected from Yunnan Province, China. We report the unambiguous assignments of the 1H and 13C NMR spectra of the new compound 7-O-methyl-8-chlorogenistein (1). Compound 1 exhibited appreciable cytotoxicity against human melanoma cell lines (B16) and human leukemia cell lines (HL60) with IC50 values of 17.5 and 19.2 μM, respectively. The MIC values of 1 for Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Candida albicans were in the range of 23-35 μM. © 2013 Springer Science+Business Media New York. Source


Chen X.-D.,Nanjing Southeast University | Rong R.,Key Laboratory of Medicinal Chemistry for Natural Resource | Wang Y.,Key Laboratory of Medicinal Chemistry for Natural Resource | Zhu L.-L.,Key Laboratory of Medicinal Chemistry for Natural Resource | And 3 more authors.
European Journal of Inorganic Chemistry | Year: 2010

Three novel copper-radical complexes [Cu(PhCOO)2-(NITpPy) 2(H2O)2] (1), [Cu2(Me 3CCOO)4(NITpPy)2] (2), and [{Cu 2(Me3CCOO)4(NITpPy)}n] (3) [NITpPy = 4,4,5,5-tetramethyl-2-(4-pyridyl)-2-imidazoline-1-oxyl 3-oxide] were synthesized and characterized structurally as well as magnetically. It is noteworthy that the syntheses of complexes 2 and 3 are similar except for the temperature of the reaction between Cu(Me3CCOO)2· 2H2O and the NITpPy radical ligand. Our magnetic study of complexes 1 and 2 reveals that the antiferromagnetic interactions occur with a J value around-10 cm-1 between copper(II) and radicals when radicals use the pyridine nitrogen atom connected to the copper(II) ion. Yet the best-fit parameters of complex 3 reveal that significant ferromagnetic interactions (J2 = 20.5 cm-1) take place in the copper radical when radicals coordinate the copper(II) ion with nitroxide directly. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Wang Y.-S.,Key Laboratory of Medicinal Chemistry for Natural Resource | Huang R.,Key Laboratory of Medicinal Chemistry for Natural Resource | Li N.-Z.,Xin Feng Hospital of Xi Shang District | Yang J.-H.,Key Laboratory of Medicinal Chemistry for Natural Resource
Molecules | Year: 2010

Four triterpenes 1-4, including a new naturally occurring oleanane-type triterpene 1, were isolated by a multi-step chromatography procedure from the leaves and twigs of Stachyurus himalaicus var. himalaicus Hook. f. et Thoms.ex Benth. The structures of the compounds were elucidated by spectroscopic methods, including HRESIMS, 1HNMR, 13C-NMR, DEPT, HMQC, HMBC and NOESY spectra. All the isolated compounds were evaluated for their in vitro cytotoxic activities against human Hela cell line. Copyright © 2010 by the authors. Source

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