Key Laboratory of Medicinal Chemistry for Natural Resource

Kunming, China

Key Laboratory of Medicinal Chemistry for Natural Resource

Kunming, China
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Wang Y.-S.,Key Laboratory of Medicinal Chemistry for Natural Resource | Huang R.,Key Laboratory of Medicinal Chemistry for Natural Resource | Li N.-Z.,Xin Feng Hospital of Xi Shang District | Yang J.-H.,Key Laboratory of Medicinal Chemistry for Natural Resource
Molecules | Year: 2010

Four triterpenes 1-4, including a new naturally occurring oleanane-type triterpene 1, were isolated by a multi-step chromatography procedure from the leaves and twigs of Stachyurus himalaicus var. himalaicus Hook. f. et Thoms.ex Benth. The structures of the compounds were elucidated by spectroscopic methods, including HRESIMS, 1HNMR, 13C-NMR, DEPT, HMQC, HMBC and NOESY spectra. All the isolated compounds were evaluated for their in vitro cytotoxic activities against human Hela cell line. Copyright © 2010 by the authors.


Chen X.-D.,Nanjing Southeast University | Rong R.,Key Laboratory of Medicinal Chemistry for Natural Resource | Wang Y.,Key Laboratory of Medicinal Chemistry for Natural Resource | Zhu L.-L.,Key Laboratory of Medicinal Chemistry for Natural Resource | And 3 more authors.
European Journal of Inorganic Chemistry | Year: 2010

Three novel copper-radical complexes [Cu(PhCOO)2-(NITpPy) 2(H2O)2] (1), [Cu2(Me 3CCOO)4(NITpPy)2] (2), and [{Cu 2(Me3CCOO)4(NITpPy)}n] (3) [NITpPy = 4,4,5,5-tetramethyl-2-(4-pyridyl)-2-imidazoline-1-oxyl 3-oxide] were synthesized and characterized structurally as well as magnetically. It is noteworthy that the syntheses of complexes 2 and 3 are similar except for the temperature of the reaction between Cu(Me3CCOO)2· 2H2O and the NITpPy radical ligand. Our magnetic study of complexes 1 and 2 reveals that the antiferromagnetic interactions occur with a J value around-10 cm-1 between copper(II) and radicals when radicals use the pyridine nitrogen atom connected to the copper(II) ion. Yet the best-fit parameters of complex 3 reveal that significant ferromagnetic interactions (J2 = 20.5 cm-1) take place in the copper radical when radicals coordinate the copper(II) ion with nitroxide directly. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.


Li X.,Key Laboratory of Medicinal Chemistry for Natural Resource | Li X.,Yunnan Nationalities University | Li X.,Baoshan College | Peng F.,Key Laboratory of Medicinal Chemistry for Natural Resource | And 2 more authors.
Advanced Synthesis and Catalysis | Year: 2012

The first metal-catalyzed 1,4-selective asymmetric addition of malonates to nitroenynes promoted by a simple chiral nickel(II)-diamine catalyst, was developed, facilitating a mild synthesis of a novel type of multifunctional chiral b-alkynyl acids bearing a nitro group. Based on this protocol, we have developed a practical and collective synthesis of a series of diverse functional molecules and building blocks including new types of chiral balkynyl- γ-amino acids, b-functionalized chiral dketo- γ-lactones, chiral g-alkylidenelactones, alkynylsubstituted pyrrole-3-carboxylic acid derivatives, tetrasubstituted furans and chiral b-alkynyl-γ-lactams. Notably, we discovered two unusual tandem reactions leading to functionalized chiral 1,5-dicarbonyl compounds. In addition, by employing simple bifunctional organocatalysts, we have developed the first regio-, diastereo- and enantioselective conjugate addition of a-substituted b-keto esters to nitroenynes, which is poorly diastereoselective with chiral nickel(II)-diamine catalysts, providing a new entry to adjacent quaternary and tertiary stereocenters in one step. Based on this protocol, we have developed a concise asymmetric synthesis of conformationally constrained bicyclic γ 2-amino acids featuring an alkynyl side chain with an adjacent quaternary carbon stereocenter. The study described here demonstrates that the mutually complementary strategy of transition metal catalysis and organocatalysis is a powerful and promising tool in catalytic asymmetric synthesis. © 2012 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim.


Miao Y.,Key Laboratory of Medicinal Chemistry for Natural Resource | Miao Y.,Qujing Normal University | Zhai Z.,Key Laboratory of Medicinal Chemistry for Natural Resource | Zhai Z.,Kunming Metallurgy Research Institute | And 4 more authors.
Materials Science and Engineering C | Year: 2010

Anatase mesoporous titania with novel morphologies were synthesized by using the skins of tomatoes, bulb onions, grapes, and garlic bulbs, respectively, as templates and used for the photodegradation of Gentian violet, methyl violet, xylenol orange, and Rhodamine B under UV light. The samples were characterized by a combination of various physicochemical techniques, such as X-ray diffraction, SEM, HRTEM, N2 adsorption/desorption, diffuse reflectance UV-Vis, and FT-IR. It was found that all of the synthesized mesoporous titania samples exhibited similar morphologies to those of the original templates. The photoactivity of P25 TiO2 for the four dyes is nearly the same while the mesoporous titania samples synthesized by using the four skins as templates exhibited varied photoactivities for the four dyes. © 2010 Elsevier B.V. All rights reserved.


Liu X.,Key Laboratory of Medicinal Chemistry for Natural Resource | He J.,Key Laboratory of Medicinal Chemistry for Natural Resource | Yang L.,Key Laboratory of Medicinal Chemistry for Natural Resource | Yang L.,Yuxi Normal University | And 4 more authors.
Catalysis Communications | Year: 2010

Liquid-phase oxidation of cyclohexane was carried out under mild reaction conditions over mesoporous Co/SBA-3 catalyst using aqueous hydrogen peroxide (30%) as oxidant and acetic acid as solvent without adding any initiator. The catalyst exhibited high substrate conversion (91.6%) and reasonable product (cyclohexanone) selectivity (64.3%). Fast hot catalyst filtration experiment proved that the catalyst acted as a heterogeneous one and it can be reused two times without losing its activity to a greater extent. © 2010 Elsevier B.V. All rights reserved.


Peng F.,Key Laboratory of Medicinal Chemistry for Natural Resource | Shao Z.,Key Laboratory of Medicinal Chemistry for Natural Resource | Shao Z.,Institute of Chemical Technology | Chan A.S.C.,Institute of Chemical Technology
Tetrahedron Asymmetry | Year: 2010

An unprecedented effect of the ligand-to-metal ratio on the stereofacial selection in the copper-catalyzed enantioselective addition of terminal alkynes to N-PMP-α-imino esters was observed. An excess of ligand was found not to be beneficial, on the contrary, an excess of copper was found to be beneficial. Moreover, both enantiomers of the alkynylation product were obtained with almost the same enantiomeric excess with the same chiral ligand by simply adjusting the ligand-to-metal ratio. The investigation of the mechanism demonstrated the presence of a positive nonlinear effect [(+)-NLE]. © 2010 Elsevier Ltd. All rights reserved.


Yang L.-J.,Yunnan Nationalities University | Ma S.-X.,Yunnan Nationalities University | Zhou S.-Y.,Yunnan Nationalities University | Chen W.,Key Laboratory of Medicinal Chemistry for Natural Resource | And 3 more authors.
Carbohydrate Polymers | Year: 2013

The inclusion complexation behavior, characterization and binding ability of naringenin with β- cyclodextrin and its derivatives were investigated in both solution and the solid state by means of XRD, DSC, SEM, 1H and 2D NMR and UV-vis spectroscopy. The results showed that the water solubility and thermal stability of naringenin were obviously increased in the inclusion complex with cyclodextrins. This satisfactory water solubility and high thermal stability of the naringenin/CD complexes will be potentially useful for their application as herbal medicines or healthcare products. © 2013 Elsevier Ltd. All rights reserved.


Shi Y.-M.,Yunnan Nationalities University | Yang L.-J.,Yunnan Nationalities University | Chen W.,Key Laboratory of Medicinal Chemistry for Natural Resource | Sun C.-J.,Key Laboratory of Medicinal Chemistry for Natural Resource | And 4 more authors.
Letters in Drug Design and Discovery | Year: 2014

A series of novel 1-((benzofuran-2-yl)methyl)-1H-triazole derivatives has been synthesized and tested in vitro against a panel of five different human tumor cell lines. The results show that the existence of benzotriazole or 1,2,3- triazole ring and substitution of the triazolyl-3-position with a naphthylacyl, 4-bromophenacyl or 4-methylbenzyl group could be crucial for promoting cytotoxic activity. Compounds 18, 19, 20 and 25 were found to have the most potent activities selectively against HL-60, SMMC-7721 and MCF-7 cell lines respectively. In particular, compound 20 was more selective towards HL-60 and A549 cell lines with IC50 values of 0.62 and 1.60 μM. © 2014 Bentham Science Publishers.


Huang R.,Key Laboratory of Medicinal Chemistry for Natural Resource | Ding Z.-G.,Yunnan University | Long Y.-F.,Yunnan University | Zhao J.-Y.,Yunnan University | And 4 more authors.
Chemistry of Natural Compounds | Year: 2013

A new natural product named 7-O-methyl-8-chlorogenistein (1) was isolated together with eight known isoflavones, 8-chlorogenistein (2), kakkatin (3), 7-O-methyl genistein (4), genistein (5), daidzein (6), glycitin (7), genistin (8), and daidzin (9), from the metabolites of Streptomyces strain YIM GS3536, which was isolated from soil sample collected from Yunnan Province, China. We report the unambiguous assignments of the 1H and 13C NMR spectra of the new compound 7-O-methyl-8-chlorogenistein (1). Compound 1 exhibited appreciable cytotoxicity against human melanoma cell lines (B16) and human leukemia cell lines (HL60) with IC50 values of 17.5 and 19.2 μM, respectively. The MIC values of 1 for Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Candida albicans were in the range of 23-35 μM. © 2013 Springer Science+Business Media New York.

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