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Wang K.,Hebei University | Wang K.,Key Laboratory of Medicinal Chemistry and Molecular Diagnosis
Progress in Chemistry | Year: 2015

In nature, helical self-assembly by non-covalent interactions is a widely observed feature. Inspired by the unique features of fascinating chiral superstructures, chemists have paid more attention to design numerous helical supramolecular assemblies. In them, carbohydrates as a natural source of chirality have been widely investigated in the construction of chiral supramolecular assembly, which possessed potential application in materials, chemistry and biology. This review aims to overview of the chiral supramolecular assembly based on aromatic molecules-carbohydrate conjugates, including perylene bisimides, azobenzene, poly(p-phenylene), porphyrins, and so on. Their gel properties, supramolecular chirality and functionalization in the mixtures of organic solution and water, or in water, and the relationship between their supramolecular chirality and the type of the carbohydrates are described. Furthermore, the potential application and future development of the chiral supramolecular assembly based on carbohydrates are discussed. ©, 2015, Chinese Academy of Sciences. All right reserved. Source

Wei H.M.,Hebei University | Zhao N.,Hebei University | Jiang N.,Hebei University | Duan W.F.,Hebei University | And 2 more authors.
Advanced Materials Research | Year: 2014

Perylene dicarboximide dimer with electron withdrawing groups were synthesized and fully characterized by 1H-NMR and 13C-NMR spectra. The effects of the substituted groups on the optical and electrochemical properties of the two compounds were investigated. The π-π* absorption peak of the perylene dicarboximide dimer compounds were red shifted from 525nm to 535nm. The band gaps of the dimer could be tuned from 2.28 eV to 2.13 eV. The first reduction wave of the dimer with electron withdrawing groups is shifted by 60 mV to more positive potential compared to that of perylene dicarboximide, suggesting the enhanced electron affinity. Furthemore, the dimer exhibited intermolecular aggregation, and decrease fluorescence quantum yield. © (2014) Trans Tech Publications, Switzerland. Source

Wang J.,Hebei University | Zhong S.,Hebei University | Duan W.,Hebei University | Gao B.,Hebei University | Gao B.,Key Laboratory of Medicinal Chemistry and Molecular Diagnosis
Tetrahedron Letters | Year: 2015

We report the synthesis and properties of perylene diimides with fluorinated substituents on the bay (BFPDIs). These BFPDIs exhibit good water solubility, high extinction coefficients, and high fluorescence quantum yields. Furthermore, these BFPDIs are used as probes in cellular imaging. © 2014 Elsevier Ltd. All rights reserved. Source

Liu S.,Hebei University | Liu S.,Key Laboratory of Pharmaceutical Quality Control of Hebei Province | He S.,Hebei University | Bai L.,Hebei University | And 5 more authors.
Chromatographia | Year: 2016

A poly(ionic liquid-glycidylmethacrylate-co-ethyleneglycol dimethacrylate) monolithic column was prepared via in situ free-radical polymerisation and used as an on-line solid-phase extraction column. The obtained monolithic column was characterized by scanning electron microscopy, Fourier transform infrared spectrometer, nitrogen adsorption–desorption measurement, and mercury intrusion porosimetry, which showed a relatively uniform and porous structure. During the on-line solid-phase extraction–high performance liquid chromatography protocol, nifedipine, nitrendipine, and felodipine were separated efficiently from human plasma using a methanol–water linear gradient at a flow rate of 1.0 mL min−1. The extraction efficiency for the targets was satisfactory with no matrix interference. Under the optimized extraction conditions, the linear regression coefficient was >0.9973; precisions for inter- and intra-day assays presented as relative standard deviations were less than 7.29 %, and the accuracy and recovery was in the range of 96–105 and 90–106 %, respectively. As a result, the polymerization monolithic column exhibited high selectivity and good permeability, and it was feasible to be used as an on-line SPE column. Meanwhile, validation assays also demonstrated acceptable sensitivity and precision for simultaneous quantitative screening of nifedipine, nitrendipine, and felodipine in human plasma. © 2016 Springer-Verlag Berlin Heidelberg Source

Wang K.-R.,Hebei University | Wang K.-R.,Key Laboratory of Medicinal Chemistry and Molecular Diagnosis | An H.-W.,Hebei University | Rong R.-X.,Hebei University | And 3 more authors.
Biosensors and Bioelectronics | Year: 2014

A new water-soluble glycocluster based on perylene bisimides PBI-12-Man has been designed and synthesized, and its specific and selective binding property with Concanavalin A (Con A) has been investigated by fluorescence spectroscopy and circular dichroism (CD) spectroscopy, which showed strong binding affinity for Con A with the binding constant of 8.2×105M-1 for monomeric mannose unit, two orders of magnitude higher than the corresponding monosaccharide ligand. Most interestingly, a fluorescence enhancement of PBI-12-Man was observed upon binding with Con A because of deaggregation of the self-assembly of PBI-12-Man induced by carbohydrate-protein interaction, and the further study of the fluorescence enhancement with macrophage cells showed that PBI-12-Man as a biocompatible agent had fluorescence imaging of the surface mannose receptor of the cells. Such fluorescence turn-on sensing of protein based on carbohydrate-protein interactions would facilitate the development of new protein-specific fluorescent probe for diagnosis and molecular imaging under live cell conditions. © 2014 Elsevier B.V. Source

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