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Jinchao Z.,Hebei University | Jinchao Z.,Key Laboratory of Medicinal Chemistry | Xiaomin P.,Hebei University | Luwei L.,Hebei University | And 3 more authors.
Micro and Nanosystems | Year: 2010

The effects of DWCNTs and MWCNTs on primary immune cells in vitro were studied at cell level. The results indicated that DWCNTs (1, 10, 25, and 50μg mL) promoted the proliferation of the spleen cells. MWCNTs had no significant effect on the proliferation of the spleen cells at concentrations of 1, 10, and 10μg mL, but promoted the proliferation at concentration of 25μg mL. DWCNTs (1, 10 25, and 50μg mL) promoted the proliferation of T lymphoid cells stimulated by ConA, MWCNTs (1 and 10μg mL) also promoted the proliferation of T lymphoid cells stimulated by ConA, but had no significant effect on the proliferation of T lymphoid cells stimulated by ConA at concentrations of 25 and 50μg mL. DWCNTs and MWCNTs promoted the proliferation of B lymphoid cells stimulated by LPS at concentrations of 10, 25, and 50μg mL, but had no significant effect on the proliferation of B lymphoid cells stimulated by LPS at concentration of of 1μg mL. DWCNTs significantly promoted NK cell activity at concentrations of 1 and 10μg mL, but turned to inhibit NK cell activity at concentrations of 25 and 50μg mL. MWCNTs significantly promoted NK cell activity at concentration of 1μg mL, then had no effect NK cell activity at concentration of 10μg mL, but turned to inhibit NK cell activity at concentrations of 25 and 50μg mL. The results suggest that the effects of CNTs on primary immune cells in vitro depend on their species and size, moreover, they are pivotal factors for switching the biological effects of CNTs from toxicity to activity, from damage to protection, or from down-regulation to up-regulation. © 2010 Bentham Science Publishers Ltd.


Wang K.-R.,Hebei University | Wang K.-R.,Key Laboratory of Medicinal Chemistry | Qian F.,Hebei University | Rong R.-X.,Hebei University | And 4 more authors.
RSC Advances | Year: 2014

Novel chiral pyrrolidinols modified naphthalimide derivatives NI1-4 were synthesized, which showed potent cytotoxic activities against Hela, MCF-7, SGC-7901 and A549 cells. The compounds exhibited strong fluorescence enhancement on binding to Ct-DNA and very good fluorescence imaging with A549 cells, providing a potent application of naphthalimide derivatives in developing novel dual therapeutic and imaging agents. This journal is © the Partner Organisations 2014.

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