Key Laboratory of Medical Molecular Imaging of Zhejiang Province

Hangzhou, China

Key Laboratory of Medical Molecular Imaging of Zhejiang Province

Hangzhou, China
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Xi W.,Zhejiang University | Xi W.,Key Laboratory of Medical Molecular Imaging of Zhejiang Province | Tian M.,University of Texas M. D. Anderson Cancer Center | Zhang H.,Zhejiang University | Zhang H.,Key Laboratory of Medical Molecular Imaging of Zhejiang Province
Neuroscience Research | Year: 2011

Cognitive neuroscience, which studies the biological basis of mental processes, widely uses neuroimaging technologies like functional magnetic resonance imaging and positron emission tomography (PET) to study the human brain. Small laboratory animals, like rodents, are commonly used in brain research and provide abundant models of human brain diseases. The development of high-resolution small-animal PET and various radiotracers together with sophisticated methods for analyzing functional brain imaging data have accelerated research on brain function and neurotransmitter release during behavioral tasks in rodents. In this review, we first summarize advances in the methodology of cognitive research brought about by the development of sophisticated methods for whole-brain imaging analysis and improvements in neuroimaging protocols. Then, we discuss basic mechanisms related to metabolic changes and the expression of neurotransmitters in various brain areas during task-induced neural activity. In particular, we discuss glucose metabolism imaging and brain receptor imaging for various receptor systems. Finally, we discuss the current status and future perspectives. Mechanisms of neurotransmitter expression will probably become an increasingly important field of study in the future, leading to more collaboration between investigators in fields such as computational and theoretical neuroscience. © 2011 Elsevier Ireland Ltd and the Japan Neuroscience Society.


Hou H.,Zhejiang University | Hou H.,Key Laboratory of Medical Molecular Imaging of Zhejiang Province | Wang C.,Beijing 307 Hospital | Jia S.,Peking University | And 3 more authors.
Neuroscience Bulletin | Year: 2014

Dopamine (DA) is considered crucial for the rewarding effects of drugs of abuse, but its role in addiction remains unclear. Positron emission tomography (PET) is the first technology used for in vivo measurement of components of the dopaminergic system in the human brain. In this article, we review the major findings from PET imaging studies on the involvement of DA in drug addiction, including presynaptic DA synthesis, vesicular monoamine transporter 2, the DA transporter, and postsynaptic DA receptors. These results have corroborated the role of DA in addiction and increased the understanding of its underlying mechanisms. © 2014, Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg.


Hou H.,Zhejiang University | Hou H.,Key Laboratory of Medical Molecular Imaging of Zhejiang Province | Hou H.,Peking University | Jia S.,Peking University | And 6 more authors.
Journal of Biomedicine and Biotechnology | Year: 2012

In recent years, internet addiction disorder (IAD) has become more prevalent worldwide and the recognition of its devastating impact on the users and society has rapidly increased. However, the neurobiological mechanism of IAD has not bee fully expressed. The present study was designed to determine if the striatal dopamine transporter (DAT) levels measured by T 99m c -TRODAT-1 single photon emission computed tomography (SPECT) brain scans were altered in individuals with IAD. SPECT brain scans were acquired on 5 male IAD subjects and 9 healthy age-matched controls. The volume (V) and weight (W) of bilateral corpus striatum as well as the T 99m c -TRODAT-1 uptake ratio of corpus striatum/the whole brain (Ra) were calculated using mathematical models. It was displayed that DAT expression level of striatum was significantly decreased and the V, W, and Ra were greatly reduced in the individuals with IAD compared to controls. Taken together, these results suggest that IAD may cause serious damages to the brain and the neuroimaging findings further illustrate IAD is associated with dysfunctions in the dopaminergic brain systems. Our findings also support the claim that IAD may share similar neurobiological abnormalities with other addictive disorders. Copyright © 2012 Haifeng Hou et al.


Chao F.,Zhejiang University | Chao F.,Key Laboratory of Medical Molecular Imaging of Zhejiang Province | Zhang H.,Zhejiang University | Zhang H.,Key Laboratory of Medical Molecular Imaging of Zhejiang Province
Journal of Biomedicine and Biotechnology | Year: 2012

Lung cancer is a common disease and the leading cause of cancer-related death in many countries. Precise staging of patients with non-small-cell lung cancer plays an important role in determining treatment strategy and prognosis. Positron emission tomography/computed tomography (PET/CT), combining anatomic information of CT and metabolic information of PET, is emerging as a potential diagnosis and staging test in patients with non-small-cell lung cancer (NSCLC). The purpose of this paper is to discuss the value of integrated PET/CT in the staging of the non-small-cell lung cancer and its health economics. Copyright © 2012 Fangfang Chao and Hong Zhang.


Hou H.,Zhejiang University | Hou H.,Key Laboratory of Medical Molecular Imaging of Zhejiang Province | Tian M.,Key Laboratory of Medical Molecular Imaging of Zhejiang Province | Zhang H.,Zhejiang University | Zhang H.,Key Laboratory of Medical Molecular Imaging of Zhejiang Province
Anatomical Record | Year: 2012

Dopamine (DA) is involved in drug reinforcement, but its role in drug addiction remains unclear. Positron emission tomography (PET) is the first technology used for the direct measurement of components of the dopaminergic system in the living human brain. In this article, we reviewed the major findings of PET imaging studies on the involvement of DA in drug addiction, especially in heroin addiction. Furthermore, we summarized PET radiotracers that have been used to study the role of DA in drug addiction. To investigate presynaptic function in drug addiction, PET tracers have been developed to measure DA synthesis and transport. For the investigation of postsynaptic function, several radioligands targeting dopamine one (D1) receptor and dopamine two (D2) receptor are extensively used in PET imaging studies. Moreover, we also summarized the PET imaging findings of heroin addiction studies, including heroin-induced DA increases and the reinforcement, role of DA in the long-term effects of heroin abuse, DA and vulnerability to heroin abuse and the treatment implications. PET imaging studies have corroborated the role of DA in drug addiction and increase our understanding the mechanism of drug addiction. © 2012 Wiley Periodicals, Inc.


Xu C.,Zhejiang University | Xu C.,Key Laboratory of Medical Molecular Imaging of Zhejiang Province | Zhang H.,Zhejiang University | Zhang H.,Key Laboratory of Medical Molecular Imaging of Zhejiang Province
BioMed Research International | Year: 2015

Somatostatin (SST) receptors (SSTRs) belong to the typical 7-transmembrane domain family of G-protein-coupled receptors. Five distinct subtypes (termed SSTR1-5) have been identified, with SSTR2 showing the highest affinity for natural SST and synthetic SST analogs. Most neuroendocrine tumors (NETs) have high expression levels of SSTRs, which opens the possibility for tumor imaging and therapy with radiolabeled SST analogs. A number of tracers have been developed for the diagnosis, staging, and treatment of NETs with impressive results, which facilitates the applications of human SSTR subtype 2 (hSSTr2) reporter gene based imaging and therapy in SSTR negative or weakly positive tumors to provide a novel approach for the management of tumors. The hSSTr2 gene can act as not only a reporter gene for in vivo imaging, but also a therapeutic gene for local radionuclide therapy. Even a second therapeutic gene can be transfected into the same tumor cells together with hSSTr2 reporter gene to obtain a synergistic therapeutic effect. However, additional preclinical and especially translational and clinical researches are needed to confirm the value of hSSTr2 reporter gene based imaging and therapy in tumors. © 2015 Caiyun Xu and Hong Zhang.


Li J.-H.,Zhejiang University | Li J.-H.,Key Laboratory of Medical Molecular Imaging of Zhejiang Province | Lu J.,Zhejiang University | Zhang H.,Zhejiang University | Zhang H.,Key Laboratory of Medical Molecular Imaging of Zhejiang Province
Evidence-based Complementary and Alternative Medicine | Year: 2013

Objective. To investigate neuroprotective effects of scutellarin (Scu) in a rat model of cerebral ischemia with use of 18F-fluorodeoxyglucose (18F-FDG) micro positron emission tomography (microPET). Method. Middle cerebral artery occlusion was used to establish cerebral ischemia. Rats were divided into 5 groups: sham operation, cerebral ischemia-reperfusion untreated (CIRU) group, Scu-25 group (Scu 25 mg/kg/d), Scu-50 group (Scu 50 mg/kg/d), and nimodipine (10 mg/Kg/d). The treatment groups were given for 2 weeks. The therapeutic effects in terms of cerebral infarct volume, neurological deficit scores, and cerebral glucose metabolism were evaluated. Levels of vascular density factor (vWF), glial marker (GFAP), and mature neuronal marker (NeuN) were assessed by immunohistochemistry. Results. The neurological deficit scores were significantly decreased in the Scu-50 group compared to the CIRU group (P < 0.001). 18F-FDG accumulation in the ipsilateral cerebral infarction increased steadily over time in Scu-50 group compared with CIRU group (P < 0.01) and Scu-25 group (P < 0.01). Immunohistochemical analysis demonstrated Scu-50 enhanced neuronal maturation. Conclusion. 18F-FDG microPET imaging demonstrated metabolic recovery after Scu-50 treatment in the rat model of cerebral ischemia. The neuroprotective effects of Scu on cerebral ischemic injury might be associated with increased regional glucose activity and neuronal maturation. © 2013 Jin-hui Li et al.


Wang J.,Zhejiang University | Wang J.,Key Laboratory of Medical Molecular Imaging of Zhejiang Province | Tian M.,University of Texas M. D. Anderson Cancer Center | Zhang H.,Zhejiang University | Zhang H.,Key Laboratory of Medical Molecular Imaging of Zhejiang Province
European Journal of Nuclear Medicine and Molecular Imaging | Year: 2011

Human neurological diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, spinal cord injury and multiple sclerosis are caused by loss of different types of neurons and glial cells in the brain and spinal cord. At present, there are no effective therapies against these disorders. Discovery of the therapeutic potential of stem cells offers new strategies for the treatment of neurological diseases. Direct assessment of stem cells' survival, interaction with the host and impact on neuronal functions after transplantation requires advanced in vivo imaging techniques. Positron emission tomography (PET) is a potential molecular imaging modality to evaluate the viability and function of transplanted tissue or stem cells in the nervous system. This review focuses on PET molecular imaging in stem cell therapy for neurological diseases. © Springer-Verlag 2011.


Liu Y.,Zhejiang University | Liu Y.,Key Laboratory of Medical Molecular Imaging of Zhejiang Province | Yu G.,Zhejiang University | Yu G.,Key Laboratory of Medical Molecular Imaging of Zhejiang Province | And 3 more authors.
Contrast Media and Molecular Imaging | Year: 2011

Optical imaging essentially refers to in vivo fluorescence imaging and bioluminescence imaging. These types of imaging are widely used visualization methods in biomedical research and are important in molecular imaging. A new generation of imaging agents called multimodal probes have emerged in the past few years. These probes can be detected by two or more imaging modalities, which harnesses the strengths of the different modalities and enables researchers to obtain more information than can be achieved using only one modality. Owing to its low cost and the large number of probes available, the optical method plays an important role in multimodality imaging. In this mini-review, we describe the available multimodal imaging probes for in vivo imaging that combine optical imaging with other modalities. Copyright © 2011 John Wiley & Sons, Ltd. Optical imaging methods are widely used in biomedical research. A new generation of imaging agents called multimodal probes which harnesses the strengths of the different modalities have emerged. In this mini-review, we describe the available multimodal imaging probes for in vivo imaging that combine optical imaging with other modalities. © 2011 John Wiley & Sons, Ltd.


Tian M.,Zhejiang University | Tian M.,Key Laboratory of Medical Molecular Imaging of Zhejiang Province | Chen Q.,Zhejiang University | Zhang Y.,Zhejiang University | And 9 more authors.
European Journal of Nuclear Medicine and Molecular Imaging | Year: 2014

Background: Internet gaming disorder is an increasing problem worldwide, resulting in critical academic, social, and occupational impairment. However, the neurobiological mechanism of internet gaming disorder remains unknown. The aim of this study is to assess brain dopamine D2 (D 2)/Serotonin 2A (5-HT2A) receptor function and glucose metabolism in the same subjects by positron emission tomography (PET) imaging approach, and investigate whether the correlation exists between D2 receptor and glucose metabolism. Methods: Twelve drug-naive adult males who met criteria for internet gaming disorder and 14 matched controls were studied with PET and 11C-N-methylspiperone (11C-NMSP) to assess the availability of D2/5-HT2A receptors and with 18F-fluoro-D-glucose (18F-FDG) to assess regional brain glucose metabolism, a marker of brain function. 11C-NMSP and 18F-FDG PET imaging data were acquired in the same individuals under both resting and internet gaming task states. Results: In internet gaming disorder subjects, a significant decrease in glucose metabolism was observed in the prefrontal, temporal, and limbic systems. Dysregulation of D2 receptors was observed in the striatum, and was correlated to years of overuse. A low level of D2 receptors in the striatum was significantly associated with decreased glucose metabolism in the orbitofrontal cortex. Conclusions: For the first time, we report the evidence that D2 receptor level is significantly associated with glucose metabolism in the same individuals with internet gaming disorder, which indicates that D 2/5-HT2A receptor-mediated dysregulation of the orbitofrontal cortex could underlie a mechanism for loss of control and compulsive behavior in internet gaming disorder subjects. © 2014 Springer-Verlag.

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