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Chen X.,Fudan University | Chen X.,Key Laboratory Of Infectious Diseases Of State Admin Of Traditional Chinese Medicine Clinical Base | Yang Z.,Fudan University | Yang Z.,Key Laboratory Of Infectious Diseases Of State Admin Of Traditional Chinese Medicine Clinical Base | And 6 more authors.
PLoS ONE | Year: 2013

Objective:The present study aimed to analyze clinical features and factors associated with treatment outcomes of H7N9 influenza A virus infection.Methods:The clinical progress in 18 H7N9-infected patients was monitored and recorded. The clinical features of H7N9 infection were noted and factors associated with treatment outcomes were analyzed by univariate analyses.Results:The average ages of patients in recovered and critical conditions were 67.0±10.83 years and 72.75±12.0 years, respectively. Renal insufficiency developed more frequently in critically ill patients (P = 0.023). The duration of traditional Chinese medicine (TCM) therapy was longer in recovered patients than in critically ill patients (P = 0.01). Laboratory tests showed that levels of C-reactive protein, serum creatinine, and myoglobin were significantly higher in critically ill patients than in recovered patients (P = 0.011, 0.04, and 0.016, respectively). Meanwhile, levels of all T cell subsets examined including total CD3+, CD4+, CD8+, and CD45+ T cells were lower in critically ill patients than in recovered patients (P = 0.033, 0.059, 0.015, and 0.039, respectively). Logistic regression analysis demonstrated that C-reactive protein level, myoglobin level and TCM therapy duration were likely associated with treatment outcomes of H7N9 infection (P = 0.032, 0.041 and 0.017, respectively).Conclusion:Elderly people may have increased risk for H7N9 virus infection. T cell-mediated responses play an important role in defense against the H7N9 virus. C-reactive protein level, myoglobin level and TCM duration may be associated with treatment outcomes of H7N9 infection. © 2013 Chen et al. Source


Yang Z.,Fudan University | Yang Z.,Key Laboratory Of Infectious Diseases Of State Admin Of Traditional Chinese Medicine Clinical Base | Zhuang L.,Fudan University | Yu Y.,Fudan University | And 9 more authors.
Discovery Medicine | Year: 2015

The relationship between members of APOBEC3 in tumor tissues and hepatocellular carcinoma prognosis was not well studied. We compared APOBEC3 expression between tumor and non-tumor tissues based on the expression profile GSE14520 from Gene Expression Omnibus (GEO), and correlated APOBEC3 in tumor tissues with outcomes of HCC patients. APOBEC3B, which was significantly up-regulated in HCC tumor tissues (P<0.001), was negatively associated with HCC overall survival by Cox regression (HR=1.005, 95%CI=1.0-1.009, P=0.033). However, no significant difference was found of APOBEC3B and HCC overall survival by Kaplan-Meier method. HCC patients with high APOBEC3F expression in tumor tissues more likely coexist with multinodular tumors than those with low APOBEC3F level (26.4% and 13.6%, respectively, P=0.018). Cox univariate and multivariate regression analyses revealed that APOBEC3F overexpression in tumor tissues was negatively associated with HCC recurrence (HR=1.132, 95%CI=1.013-1.265, P=0.028). Additionally, the higher the APOBEC3F expressed, the greater risk of poor recurrence-free survival for HCC patients (mean survival time high=32.25 and low=42.68 months, respectively; log rank P=0.012) when grouped by lower quartile cut-off of 10.98. Conclusions: Overexpression of APOBEC3F in tumor tissues is potentially predictive for poor recurrence-free survival from HBV-HCC patients. The role of other APOBEC3 members in HCC development needed further research. © 2016, Discovery Medicine. Source

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