Key Laboratory Of Infectious Diseases Of State Admin Of Traditional Chinese Medicine Clinical Base

Shanghai, China

Key Laboratory Of Infectious Diseases Of State Admin Of Traditional Chinese Medicine Clinical Base

Shanghai, China

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Chen X.,Fudan University | Chen X.,Key Laboratory Of Infectious Diseases Of State Admin Of Traditional Chinese Medicine Clinical Base | Yang Z.,Fudan University | Yang Z.,Key Laboratory Of Infectious Diseases Of State Admin Of Traditional Chinese Medicine Clinical Base | And 6 more authors.
PLoS ONE | Year: 2013

Objective:The present study aimed to analyze clinical features and factors associated with treatment outcomes of H7N9 influenza A virus infection.Methods:The clinical progress in 18 H7N9-infected patients was monitored and recorded. The clinical features of H7N9 infection were noted and factors associated with treatment outcomes were analyzed by univariate analyses.Results:The average ages of patients in recovered and critical conditions were 67.0±10.83 years and 72.75±12.0 years, respectively. Renal insufficiency developed more frequently in critically ill patients (P = 0.023). The duration of traditional Chinese medicine (TCM) therapy was longer in recovered patients than in critically ill patients (P = 0.01). Laboratory tests showed that levels of C-reactive protein, serum creatinine, and myoglobin were significantly higher in critically ill patients than in recovered patients (P = 0.011, 0.04, and 0.016, respectively). Meanwhile, levels of all T cell subsets examined including total CD3+, CD4+, CD8+, and CD45+ T cells were lower in critically ill patients than in recovered patients (P = 0.033, 0.059, 0.015, and 0.039, respectively). Logistic regression analysis demonstrated that C-reactive protein level, myoglobin level and TCM therapy duration were likely associated with treatment outcomes of H7N9 infection (P = 0.032, 0.041 and 0.017, respectively).Conclusion:Elderly people may have increased risk for H7N9 virus infection. T cell-mediated responses play an important role in defense against the H7N9 virus. C-reactive protein level, myoglobin level and TCM duration may be associated with treatment outcomes of H7N9 infection. © 2013 Chen et al.


Yang Z.,Fudan University | Yang Z.,Key Laboratory Of Infectious Diseases Of State Admin Of Traditional Chinese Medicine Clinical Base | Zhuang L.,Fudan University | Yu Y.,Fudan University | And 9 more authors.
Discovery Medicine | Year: 2015

The relationship between members of APOBEC3 in tumor tissues and hepatocellular carcinoma prognosis was not well studied. We compared APOBEC3 expression between tumor and non-tumor tissues based on the expression profile GSE14520 from Gene Expression Omnibus (GEO), and correlated APOBEC3 in tumor tissues with outcomes of HCC patients. APOBEC3B, which was significantly up-regulated in HCC tumor tissues (P<0.001), was negatively associated with HCC overall survival by Cox regression (HR=1.005, 95%CI=1.0-1.009, P=0.033). However, no significant difference was found of APOBEC3B and HCC overall survival by Kaplan-Meier method. HCC patients with high APOBEC3F expression in tumor tissues more likely coexist with multinodular tumors than those with low APOBEC3F level (26.4% and 13.6%, respectively, P=0.018). Cox univariate and multivariate regression analyses revealed that APOBEC3F overexpression in tumor tissues was negatively associated with HCC recurrence (HR=1.132, 95%CI=1.013-1.265, P=0.028). Additionally, the higher the APOBEC3F expressed, the greater risk of poor recurrence-free survival for HCC patients (mean survival time high=32.25 and low=42.68 months, respectively; log rank P=0.012) when grouped by lower quartile cut-off of 10.98. Conclusions: Overexpression of APOBEC3F in tumor tissues is potentially predictive for poor recurrence-free survival from HBV-HCC patients. The role of other APOBEC3 members in HCC development needed further research. © 2016, Discovery Medicine.

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