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Chen Q.,Peking University | Chen Q.,Key Laboratory of Epidemiology | Yu C.-Q.,Peking University | Yu C.-Q.,Key Laboratory of Epidemiology | And 22 more authors.
Pharmacogenomics | Year: 2011

Aim: Angiotensin-converting enzyme inhibitors are widely used antihypertensive drugs with individual response variation. We studied whether interactions of AGT, AGTR1 and ACE2 gene polymorphisms affect this response. Materials & methods: Our study is based on a 3-year field trial with 1831 hypertensive patients prescribed benazepril. Generalized multifactor dimensionality reduction was used to explore interaction models and logistic regressions were used to confirm them. Results: A two-locus model involving the AGT and ACE2 genes was found in males, the sensitive genotypes showed an odds ratio (OR) of 1.9 (95% CI: 1.3-2.8) when compared with nonsensitive genotypes. Two AGT-AGTR1 models were found in females, with an OR of 3.5 (95% CI: 2.0-5.9) and 3.1 (95% CI: 1.8-5.3). Conclusion: Gender-specific gene-gene interactions of the AGT, AGTR1 and ACE2 genes were associated with individual variation of response to benazepril. Further studies are needed to confirm this finding. © 2011 Future Medicine Ltd.

Song J.-Y.,Peking University | Song J.-Y.,Key Laboratory of Epidemiology | Wang H.-J.,Peking University | Ma J.,Peking University | And 5 more authors.
Obesity Facts | Year: 2011

Aims: We aimed to identify whether the risk G-allele was associated with fasting glucose level and other pre-diabetic and obesity-related phenotypes in Chinese children and adolescents. Methods: The rs10830963 polymorphism in MTNR1B was genotyped in 2,030 Chinese children and adolescents of two independent studies. Association with fasting glucose levels and risk of impaired fasting glucose (IFG) were initially tested. Subsequently we analyzed the association with fasting insulin, homeostasis model assessment for insulin resistance (HOMA-IR) and for beta cell function (HOMA-B), the quantitative insulin sensitivity check index (QUICK) and obesity-related phenotypes (BMI standard deviation score, waist circumference etc.). Results: The G-allele of rs10830963 was associated with increased fasting glucose level in Chinese children and adolescents (increase of 0.072 mmol/l per G-allele, 95% CI 0.034-0.111, p = 2.46 × 10-4). The G-allele was also associated with an increased risk of IFG (OR = 1.21, 95% CI 1.00-1.46, nominal p = 0.048). We found the glucose-raising G-allele was nominally associated with reduced HOMA-B. No association to other pre-diabetic or obesity-related phenotypes was detected. Conclusions: The rs10830963 polymorphism in MTNR1B was associated with increased fasting glucose and risk of IFG in Chinese children and adolescents. The effect may result from reduced pancreatic beta cell function, but the mechanism awaits further studies. Copyright © 2011 S. Karger AG, Basel.

Wang D.,Peking University | Wang D.,Key Laboratory of Epidemiology | Ma J.,Peking University | Zhang S.,Peking University | And 4 more authors.
Obesity | Year: 2010

Recently, large-scaled studies suggested a negative association of the infrequent allele of the melanocortin-4 receptor (MC4R) V103I polymorphism with obesity. We conducted a Chinese case-control study, meta-analysis in East Asians and in all populations, in order to further assess the association between the V103I polymorphism and reduced body weight and to explore whether the association varies among different ethnic groups. We conducted a case-control study to analyze this polymorphism in 2,012 children of two independent study groups from Beijing, China, no association was found between the V103I polymorphism and obesity or obesity-related phenotypes (P 0.10). In the meta-analysis of 3,526 individuals from six East Asian studies, I103 carriers had a 31% lower risk for obesity (odds ratio (OR) = 0.69, 95% confidence interval (CI): 0.50-0.94, P = 0.02). Subsequently, we performed a large meta-analysis of the six East Asian studies and 31 studies of other ethnic groups, involving 55,195 individuals with 19,822 obese cases and 35,373 nonobese controls. In total, the individuals with I103 allele had a 21% lower risk for obesity (OR = 0.79, 95% CI: 0.71-0.88, P 0.0001). In conclusion, this study confirmed and extended the previous findings, suggesting the MC4R V103I polymorphism is negatively associated with human obesity. It provides significant evidence for the association in East Asian populations. Further large-scaled studies in East Asian populations are needed to validate the association.

Hong Z.H.,Key Laboratory of Epidemiology
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2012

To study the application of statistics on Chronic-diseases-relating observational research papers which were recently published in the Chinese Medical Association Magazines, with influential index above 0.5. Using a self-developed criterion, two investigators individually participated in assessing the application of statistics on Chinese Medical Association Magazines, with influential index above 0.5. Different opinions reached an agreement through discussion. A total number of 352 papers from 6 magazines, including the Chinese Journal of Epidemiology, Chinese Journal of Oncology, Chinese Journal of Preventive Medicine, Chinese Journal of Cardiology, Chinese Journal of Internal Medicine and Chinese Journal of Endocrinology and Metabolism, were reviewed. The rate of clear statement on the following contents as: research objectives, t target audience, sample issues, objective inclusion criteria and variable definitions were 99.43%, 98.57%, 95.43%, 92.86% and 96.87%. The correct rates of description on quantitative and qualitative data were 90.94% and 91.46%, respectively. The rates on correctly expressing the results, on statistical inference methods related to quantitative, qualitative data and modeling were 100%, 95.32% and 87.19%, respectively. 89.49% of the conclusions could directly response to the research objectives. However, 69.60% of the papers did not mention the exact names of the study design, statistically, that the papers were using. 11.14% of the papers were in lack of further statement on the exclusion criteria. Percentage of the papers that could clearly explain the sample size estimation only taking up as 5.16%. Only 24.21% of the papers clearly described the variable value assignment. Regarding the introduction on statistical conduction and on database methods, the rate was only 24.15%. 18.75% of the papers did not express the statistical inference methods sufficiently. A quarter of the papers did not use 'standardization' appropriately. As for the aspect of statistical inference, the rate of description on statistical testing prerequisite was only 24.12% while 9.94% papers did not even employ the statistical inferential method that should be used. The main deficiencies on the application of Statistics used in papers related to Chronic-diseases-related observational research were as follows: lack of sample-size determination, variable value assignment description not sufficient, methods on statistics were not introduced clearly or properly, lack of consideration for pre-requisition regarding the use of statistical inferences.

Hong Z.H.,Key Laboratory of Epidemiology
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi | Year: 2011

To study the prevalence rates of knowledge, attitudes and use of the nutrition labeling and related influential factors in Hangzhou supermarket consumers. Using a self-developed survey questionnaire, randomly selected customers were conducted a face-to-face interview program in a large supermarket of Hangzhou city. 586 people were interviewed, including 202 males and 384 females, with the mean age as 41.6 ± 17.23 years. The accuracy rates of 6 questions related to the 'ability of choosing healthier food by using the Nutrition Facts Labels' were as follows: dietary fiber (71.84%), fat (70.99%), calcium (60.75%), salt (58.36%), energy (50.85%) and sugar (39.42%). The support rates of the three attitudes indicators were "support marking the Nutrition Facts Label" (90.44%), "support marking the nutrition claims" (87.03%) and "want to know more relative knowledge" (77.13%). There were 58.36% and 80.03% first-time buyers who would read the Nutrition Facts Food Labels and the Nutrition Claims. Through logistic model analysis, male, youth, low-educated people were found to be the risk factors related to the nutrition label reading behavior. The capacity of the reading, understanding and correct application of nutrition labeling among consumers was not satisfactory. Improvement on the readability and the authority of nutrition labeling and the development of the national nutrition knowledge and health education programs were in urgent needs.

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