Cao J.-L.,Xi'an Jiaotong University |
Cao J.-L.,Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education |
Cao J.-L.,Key Laboratory of Microelement and Endemic Disease of Ministry of Health
Journal of Xi'an Jiaotong University (Medical Sciences) | Year: 2012
Proteoglycan, a type of glycoconjugate, consists of a core protein and one or more covalently attached glycosaminoglycan chains. It is an important component of cell membrane, fundus membrane, especially in extracellular matrix. It is also related to the histological structure and function of cells. With the advances in scientific research, proteoglycan metabolism has been found to have association with the growth and degradation of bone, cartilage and neural tissues. Recent studies also indicate that it is related to the development of cardiovascular diseases and tumors. The relationship of proteoglycan metabolism with the structure and function of cartilage and pathogenesis of osteoarthropathy will be discussed in this paper.