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Liu Q.-W.,Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education | Bin H.-C.,Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education | Yang J.-S.,Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education | Yang J.-S.,University of Sichuan
Organic Letters | Year: 2013

A new β-stereoselective d- and l-arabinofuranosylation method has been developed employing 5-O-(2-quinolinecarbonyl) substituted arabinosyl ethyl thioglycosides as glycosyl donors. The approach allows a wide range of acceptor substrates to be used; the β-selectivity is good-to-excellent. Stereoselective synthesis of a mannose-capped octasaccharide portion from a mycobacterial cell wall polysaccharide was then carried out to demonstrate the utility of this methodology. © 2013 American Chemical Society. Source


Huang J.-S.,Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education | Huang J.-S.,University of Sichuan | Huang W.,Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education | Huang W.,University of Sichuan | And 8 more authors.
Angewandte Chemie - International Edition | Year: 2015

An efficient methodology for the synthesis of α-Kdo glycosidic bonds has been developed with 5,7-O-di-tert-butylsilylene (DTBS) protected Kdo ethyl thioglycosides as glycosyl donors. The approach permits a wide scope of acceptors to be used, thus affording biologically significant Kdo glycosides in good to excellent chemical yields with complete α-selectivity. The synthetic utility of an orthogonally protected Kdo donor has been demonstrated by concise preparation of two α-Kdo-containing oligosaccharides. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

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