Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education

Chengdu, China

Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education

Chengdu, China

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Huang J.-S.,Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education | Huang J.-S.,University of Sichuan | Huang W.,Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education | Huang W.,University of Sichuan | And 8 more authors.
Angewandte Chemie - International Edition | Year: 2015

An efficient methodology for the synthesis of α-Kdo glycosidic bonds has been developed with 5,7-O-di-tert-butylsilylene (DTBS) protected Kdo ethyl thioglycosides as glycosyl donors. The approach permits a wide scope of acceptors to be used, thus affording biologically significant Kdo glycosides in good to excellent chemical yields with complete α-selectivity. The synthetic utility of an orthogonally protected Kdo donor has been demonstrated by concise preparation of two α-Kdo-containing oligosaccharides. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Liu Q.-W.,Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education | Bin H.-C.,Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education | Yang J.-S.,Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education | Yang J.-S.,University of Sichuan
Organic Letters | Year: 2013

A new β-stereoselective d- and l-arabinofuranosylation method has been developed employing 5-O-(2-quinolinecarbonyl) substituted arabinosyl ethyl thioglycosides as glycosyl donors. The approach allows a wide range of acceptor substrates to be used; the β-selectivity is good-to-excellent. Stereoselective synthesis of a mannose-capped octasaccharide portion from a mycobacterial cell wall polysaccharide was then carried out to demonstrate the utility of this methodology. © 2013 American Chemical Society.

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