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Cui Y.,Tianjin University | Cui Y.,Key Laboratory of Composites and Functional Materials | Gong X.,Tianjin University | Gong X.,Key Laboratory of Composites and Functional Materials | And 10 more authors.
Journal of Materials Chemistry | Year: 2012

In this paper, a biocompatible poly(γ-glutamic acid) (PGA)-based polymer with numerous thiol groups grafted onto the backbone was self-synthesized. It has been successfully used to prepare water-soluble quantum dots (QDs) with high luminescence and high stability. FTIR spectroscopy, transmission electron microscopy, dynamic light scattering, spectrofluoro- photometry, fluorescence microscopy and flow cytometer were used to characterize QDs@poly(γ-glutamic acid)-grafted cysteamine (PGA-g-MEA). The results indicated that QDs@PGA-g-MEA with an identical small size were highly luminescent with a well maintained, even increased, photoluminescence (PL) intensity when compared with the tributylphosphine oxide (TOPO) coated QDs. Meanwhile, they were highly stable in aqueous solution under a wide range of pH from 2 to 12, as well as under different temperatures. The QDs@PGA-g-MEA were then applied as fluorescent probes to detect human IgGs and the results demonstrated that QDs@PGA-g-MEA had great potential for application in immunofluorescence. © 2012 The Royal Society of Chemistry.

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