Key Laboratory of Combined Multi organ Transplantation Ministry of Public Health Key Laboratory of Organ Transplantation Hangzhou China

Laboratory of, China

Key Laboratory of Combined Multi organ Transplantation Ministry of Public Health Key Laboratory of Organ Transplantation Hangzhou China

Laboratory of, China

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Ye S.,Zhejiang University | Song W.,Key Laboratory of Combined Multi organ Transplantation Ministry of Public Health Key Laboratory of Organ Transplantation Hangzhou China | Xu X.,Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province Zhejiang Provincial Peoples Hospital Hangzhou China | Zhao X.,Key Laboratory of Combined Multi organ Transplantation Ministry of Public Health Key Laboratory of Organ Transplantation Hangzhou China | Yang L.,Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province Zhejiang Provincial Peoples Hospital Hangzhou China
FEBS Letters | Year: 2016

Insulin-like growth factor 2 (IGF2) mRNA-binding protein 2 (IGF2BP2) is a post-transcriptional regulatory factor implicated in mRNA localization, stability, and translational control. However, the role of IGF2BP2 regulation in colorectal cancer (CRC) and its underlying mechanism remain elusive. In this study, we found that IGF2BP2 expression is markedly increased in CRC tissues. Notably, IGF2BP2 overexpression strikingly enhanced the proliferation and survival of CRC cells in vitro, whereas its shRNA-mediated silencing resulted in the opposite. Molecular function analyses revealed that IGF2BP2 regulates RAF1 expression through blocking its degradation by miR-195. These results identify IGF2BP2 as a post-transcriptional regulatory mRNA-binding factor that contributes to CRC carcinogenesis. © 2016 Federation of European Biochemical Societies.

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