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Sheng C.,Central South University | Sheng C.,Key Laboratory of Chinese Gan of State Administration of Traditional Chinese Medicine of China | Peng W.,Central South University | Xia Z.-A.,Central South University | And 7 more authors.
BMC Complementary and Alternative Medicine | Year: 2015

Background: The efficacy of ginsenoside treatment on cognitive decline in individuals with Alzheimer's disease (AD) has yet to be investigated. In this protocal, we conducted a systematic review to evaluate the effect of ginsenosides on cognitive deficits in experimental rodent AD models. Methods: We identified eligible studies by searching seven electronic databases spanning from January 1980 to October 2014. We assessed the study quality, evaluated the efficacy of ginsenoside treatment, and performed a stratified meta-analysis and meta-regression analysis to assess the influence of the study design on ginsenoside efficacy. Results: Twelve studies fulfilled our inclusion criteria from a total of 283 publications. The overall methodological quality of these studies was poor. The meta-analysis revealed that ginsenosides have a statistically significant positive effect on cognitive performance in experimental AD models. The stratified analysis revealed that ginsenoside Rg1 had the greatest effect on acquisition and retention memory in AD models. The effect size was significantly higher for both acquisition and retention memory in studies that used female animals compared with male animals. Conclusions: We conclude that ginsenosides might reduce cognitive deficits in AD models. However, additional well-designed and well-reported animal studies are needed to inform further clinical investigations. © 2015 Sheng et al.

Yang A.-L.,Central South University | Yang A.-L.,Key Laboratory of Chinese Gan of State Administration of Traditional Chinese Medicine of China | Zhou H.-J.,Central South University | Lin Y.,Central South University | And 8 more authors.
Journal of the Neurological Sciences | Year: 2012

Spontaneous intracerebral hemorrhage (ICH) is one of the most severe types of stroke. Thrombin has been reported to participate in brain repair following ICH and play an important role in angiogenesis. Our previous studies have shown that ICH induces angiogenesis in damaged rat brain, accompanied by upregulation of expression of thrombospondin (TSP)-1 and TSP-2. The aim of the present study was to investigate whether the expression of TSP-1 and TSP-2 was regulated by thrombin in rat brain following ICH. A rat model of ICH was induced by injection of autologous blood into the right globus pallidus (GP). Hirudin, a thrombin specific inhibitor, or thrombin was injected into the GP. Immunohistochemistry, quantitative real-time reverse-transcription polymerase chain reaction (RT-PCR) and western blot assays were applied. Results showed that ICH induced an increase in the expression of TSP-1 mRNA and TSP-2 mRNA after ICH, whereas hirudin significantly inhibited the expression of TSPs mRNA after ICH (P < 0.05). In contrast, sole thrombin treatment in normal rats induced strong expression of TSP-1 or TSP-2 in the blood vessels around the damaged brain region when compared with those without thrombin treatment. Western blot analysis data confirmed that the protein levels of TSPs were significantly increased when compared with those in the sham control group (P < 0.01). These findings support that thrombin positively regulates the expression of TSP-1 and TSP-2 after ICH, which may be involved in modulating angiogenesis in injured brains following ICH. © 2012 Elsevier B.V. All rights reserved.

Sheng C.-X.,Central South University | Sheng C.-X.,Key Laboratory of Chinese Gan of State Administration of Traditional Chinese Medicine of China | Chen Z.-Q.,Central South University | Chen Z.-Q.,Key Laboratory of Chinese Gan of State Administration of Traditional Chinese Medicine of China | And 10 more authors.
Chinese Journal of Integrative Medicine | Year: 2015

Objectives: To evaluate the effectiveness and safety of Guipi Decoction (归脾汤, GPD) as an adjunctive in the treatment of depression. Methods: A review of all relevant studies retrieved from a search of the following databases were conducted without any language restriction: Excerpt Medica Database (EMBASE), PubMed, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure (CNKI), VIP Information, Wanfang Data, and the Chinese Biomedical Literature Database. Papers published until February 2013 were taken into consideration. The analysis was performed using the Cochrane software Revman 5.1. Results: Nine randomized controlled trials involving 620 patients with depression were included in this review. The meta-analysis revealed that compared with antidepressant therapy alone, treatment with a combination of GPD and an antidepressant drug signifificantly improved the symptoms of depression [weighted mean difference (WMD):–3.09; 95% confifidence interval (CI):–4.11 to–2.07] and increased the rates of effectiveness (OR: 4.75; 95% CI: 2.66–8.51) as well as recovery (OR: 1.73; 95% CI: 1.17–2.56). The adverse effects of GPD were not found to be signifificant in these studies. Conclusions: The fifindings of this meta-analysis were in keeping with the notion that GPD formulations were effective in the treatment of depression without causing any serious adverse effects. However, currently available evidence was of low quality and therefore inadequate to justify a strong recommendation of using GPD formulations in the management of depression. © 2015 Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg

Zhou H.-J.,Central South University | Zhou H.-J.,Key Laboratory of Chinese Gan of State Administration of Traditional Chinese Medicine of China | Zhang H.-N.,Central South University | Zhang H.-N.,Key Laboratory of Chinese Gan of State Administration of Traditional Chinese Medicine of China | And 13 more authors.
Journal of Neurosurgery | Year: 2010

Object. Spontaneous intracerebral hemorrhage (ICH) is among the most intractable forms of stroke. Angiogenesis, an orchestrated balance between proangiogenic and antiangiogenic factors, is a fundamental process to brain development and repair by new blood vessel formation from preexisting ones and can be induced by ICH. Thrombospondin (TSP)-1 and TSP-2 are naturally occurring antiangiogenic factors. The aim of this study was to observe their expression in rat brains with ICH. Methods. Intracerebral hemorrhage was induced in adult male Sprague-Dawley rats by stereotactic injection of collagenase VII or autologous blood into the right globus pallidus. The expression of TSP-1 and -2 was evaluated by immunohistochemistry and quantitative real-time reverse transcription-polymerase chain reaction analysis. Results. After the induction of ICH, some TSP1- or TSP2-immunoreactive microvessels resided around the hematoma for ∼ 7 days and extended into a clot thereafter. Cerebral endothelial cells expressed the TSPs. The expression of TSP-1 and TSP-2 mRNA peaked at 4 and 14 days after collagenase-induced ICH, respectively. Conclusions. Findings in this study suggest that ICH can alter the expression of TSP-1 and TSP-2, which may be involved in modulating angiogenesis in brains following ICH.

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