Chen W.,Longgang Central Hospital of Shenzhen |
Shi X.,Longgang Central Hospital of Shenzhen |
Liu Y.,Central South University |
Li C.,Key Laboratory of Cancer Proteomics of Ministry of Health |
And 2 more authors.
Journal of Central South University (Medical Sciences) | Year: 2012
Objective: To explore whether oncogenes DJ-I and HSP27 are associated with invasiveness of human pituitary adenoma. Methods: Total proteins were extracted from samples of 20 invasive and 20 non-invasive pituitary adenomas and the expression of DJ-I and HSP27 was analyzed by Western blot. The correlation of DJ-land HSP27 with the invasiveness of pituitary adenoma was analyzed. Results: The strong positive rates of DJ-I and HSP27 in the 20 invasive pituitary adenoma were 70% (14/20) and 80% ( 16/20), respectively. The invasive group had significantly higher expression of DJ-I and HSP27 proteins than the noninvasive group [10% (2/20), 10% (2/20), respectively]. There was a positive correlation between the expression of DJ-I, HSP27 proteins and the invasiveness of pituitary adenoma as judged by the Spearman rank correlation test (P<0.05). Conclusion: The proliferative activity and abnormal expression of oncogenes DJ-I and HSP27 may play a significant role in tumorigenesis and progression of pituitary adenoma. There was a significant correlation between the expression of DJ-I and HSP27 and the invasiveness of pituitary adenoma.