Liu F.,Tianjin Medical University |
Liu F.,Key Laboratory of Breast Cancer Prevention and Therapy |
Liu F.,Key Laboratory of Cancer Prevention and Therapy of Tianjin City |
Niu Y.,Tianjin Medical University |
And 17 more authors.
Chinese Journal of Pathology
Objective: To investigate the expression of vacuole membrane protein 1 (Vmp1) and its prognostic value in invasive ductal carcinoma (IDC) and concomitant ductal carcinoma in situ (DCIS) of the breast. Methods: The expression and location of Vmpl in the breast tissues from 102 patients with IDC and 32 concomitant DCIS were detected by immunohistochemical SP method, and the relationship with clinicopathologic parameters was analyzed. Results: Vmpl expression was observed in the cytoplasm of the cancer cells in 57. 8% (59/102) cases, and correlated with grade (χ2 = 12. 644, P = 0. 002), pTNM stage (χ2 = 11.987, P = 0. 001), node status (χ2 = 9.341, P = 0.002), tumor diameter (χ2 = 7. 630, P = 0. 022) as well as Nottingham Prognostic Index (NPI; χ2 =15.561, P = 0.000). The expression of Vmp1 in concomitant DCIS was higher than that in IDC (81.3% vs 56.3%; χ2 =4.655, P = 0.031). In this cohort, the mean disease-free survival was 81.2 months; the 5-year overall survival rate was 90.2% (92/102) and the disease-free survival rate was 81.4% (83/102). Vmpl expression had significant influence on disease-free survival time, with Vmp1-negative patients showing poor prognosis (χ2 =11. 192, P=0.001). COX's proportional hazards regression model revealed that Vmp1 was a protective factor, with relative risk < 1. Conclusions: The detection of Vmp1 in IDC may be helpful for prognosis prediction; the patients with Vmpl expression may have a better prognosis. Source