Key Laboratory of Blood Safety Research of Ministry of Health

China

Key Laboratory of Blood Safety Research of Ministry of Health

China
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He J.,Key Laboratory of Blood Safety Research of Ministry of Health | Dong L.-N.,Key Laboratory of Blood Safety Research of Ministry of Health | Wang W.,Key Laboratory of Blood Safety Research of Ministry of Health | Zhu F.-M.,Key Laboratory of Blood Safety Research of Ministry of Health | Lv H.-J.,Key Laboratory of Blood Safety Research of Ministry of Health
Tissue Antigens | Year: 2014

HLA-Cz.ast;14:52 has one nucleotide difference from HLA-Cz.ast;14:02:01 at position 427G>C in exon 3. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd .


Dai W.-J.,First Peoples Hospital of Hangzhou | Zhu F.-M.,Key Laboratory of Blood Safety Research of Ministry of Health | Yan L.-X.,Key Laboratory of Blood Safety Research of Ministry of Health | Zhao H.-C.,First Peoples Hospital of Hangzhou
Chinese Journal of Medical Genetics | Year: 2010

Objective: To investigate the polymorphisms of HLA-DPA1 and HLA-DPB1 loci of Han population in Zhejiang province of China. Methods: The alleles of HLA-DPA1 and HLA-DPB1 loci in 100 unrelated healthy individuals were analyzed using polymerase chain reaction-sequence based typing. Results: Eight HLA-DPA1 alleles and 19 HLA-DPB1 alleles were found in the population. The HLA-DPA1 alleles with higher frequencies were DPA1 * 020202 (47.0%), DPA1 * 010301 (38.5%) and DPA1 * 020101(10.5%). The HLA-DPB1 alleles with higher frequencies were DPB1 * 0501, DPB1 * 020102 and DPB1 * 040101. The frequencies were 39.5%, 13.5% and 13.0%, respectively. A total of 44 estimated DPA1-DPB1 haplotypes were detected. The HLA-DPA1 * 020202-DPB1 * 0501(29.5%) was the most frequent haplotype. Conclusion: The polymorphism data of the HLA-DPA1 and -DPB1 were obtained in Han population in Zhejiang province of China. There was linkage disequilibrium between the two loci.

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