Key Laboratory of Biomechanics of Hebei Province

Shijiazhuang, China

Key Laboratory of Biomechanics of Hebei Province

Shijiazhuang, China

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Zhu Y.,Hebei Medical University | Zhu Y.,Key Laboratory of Biomechanics of Hebei Province | Zhang F.,Hebei Medical University | Zhang F.,Key Laboratory of Biomechanics of Hebei Province | And 8 more authors.
Journal of Hospital Infection | Year: 2015

Many of the mooted risk factors associated with periprosthetic joint infection (PJI) after total joint arthroplasty (TJA) remain controversial and are not well characterized. Online and manual searches were performed using Medline, Embase, Chinese National Knowledge Infrastructure and the Cochrane Central Database from January 1980 to March 2014). For inclusion, studies had to meet the quality assessment criteria of the CONSORT statement, and be concerned with evaluation of risk factors for PJI after TJA. Two reviewers extracted the relevant data independently and any disagreements were resolved by consensus. Fourteen studies were included in this meta-analysis. The following significant risk factors for PJI were identified: body mass index (both continuous and dichotomous variables); diabetes mellitus; corticosteroid therapy; hypoalbuminaemia; history of rheumatoid arthritis; blood transfusion; presence of a wound drain; wound dehiscence; superficial surgical site infection; coagulopathy; malignancy, immunodepression; National Nosocomial Infections Surveillance Score ≥2; other nosocomial infection; prolonged operative time; and previous surgery. Factors that were not significantly associated with PJI were: cirrhosis; hypothyroidism; urinary tract infection; illicit drug abuse; alcohol abuse; hypercholesterolaemia; hypertension, ischaemic heart disease; peptic ulcer disease; hemiplegia or paraplegia; dementia; and operation performed by a staff surgeon (vs a trainee). Strategies to prevent PJI after TJA should focus, in particular, on those patients at greatest risk of infection according to their individual risk factors. © 2014 The Healthcare Infection Society.


Zhang B.,Hebei Medical University | Zhu Y.,Hebei Medical University | Zhu Y.,Key Laboratory of Biomechanics of Hebei Province | Zhang F.,Hebei Medical University | And 7 more authors.
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine | Year: 2015

Background: This systematic review and meta-analysis aims to critically compare the outcomes of plate fixation (PF) versus intramedullary fixation (IF) for the treatment of mid-shaft clavicle fractures. Methods: Relevant original studies were searched in electronic databases of Medline, Embase, Cochrane central database and CNKI (all through October 2014). The study was performed according to the PRISMA statement. Studies that investigated the comparing effectiveness or complications between both groups and provided sufficient data of interest were included in this meta-analysis. Results: Thirteen studies fulfilling inclusion and exclusion criteria were included in this meta-analysis, which included 479 participants in PF group and 457 in IF group. Compared to PFs, IFs outperformed PFs associated with a reduced surgery time, a shorter incision, rapid union time, better shoulder function recovery at 6months and fewer complications of symptomatic hardware, refracture after hardware removal and hypertrophic scar. In other aspects such as functional recovery at 12months and 24months follow-up, shoulder motion range, complications of superficial infection,temporary brachial plexus lesion, nonunion, malunion, delayed union, implant failure, major revision needed, both techniques were comparable. Conclusions: The present evidence from this meta-analysis suggested that IF was a more advantaged method for the treatment of midshaft clavicle fractures. This present study might aid surgeons in making evidence-based decision about optimal surgical treatment of mid-shaft clavicular fracture. © Zhang et al.; licensee BioMed Central.


Zhu Y.,Hebei Medical University | Zhu Y.,Key Laboratory of Biomechanics of Hebei Province | Tian Y.,Hebei Medical University | Tian Y.,Key Laboratory of Biomechanics of Hebei Province | And 8 more authors.
International Orthopaedics | Year: 2015

Purpose: This meta-analysis of randomised controlled trials (RCTs) aimed to investigate the comparative outcomes between plate fixation and intramedullary fixation for management of mid-shaft clavicle fractures. Methods: Relevant original studies were searched in electronic databases of PubMed, Medline, Embase and CNKI (all through October 2014). RCTs that investigated the effectiveness or complications between both groups and provided sufficient data of interest were included in this meta-analysis. Results: Five RCTs fulfilled inclusion and exclusion criteria and were included in this meta-analysis, with 128 participants in a plate fixation (PF) group and 157 in an intramedullary fixation (IF) group. Patients were followed up for at least one year in all the studies. Compared to PFs, IF is a better alternative for treatment of MSCFs than PF, with a reduced surgery time, a shorter incision, rapid union time, better shoulder function at one year and fewer complications such as infection, symptomatic hardware and hypertrophic scar. In other aspects such as complications of implant failure, refracture and nonunion, both techniques were comparable. Conclusions: If the surgery is indicated, intramedullary fixation has more advantages than plate fixation for treatment of mid-shaft clavicular fracture. This definitive conclusion could aid surgeons in making evidence-based decisions when selecting an optimal fixation pattern. © 2015, SICOT aisbl.


Liu S.,Hebei Medical University | Liu S.,Key Laboratory of Biomechanics of Hebei Province | Zhu Y.,Hebei Medical University | Zhu Y.,Key Laboratory of Biomechanics of Hebei Province | And 8 more authors.
Clinical Rehabilitation | Year: 2015

Objectives: To achieve a quantitative and comprehensive conclusion concerning the risk factors for the second contralateral hip fracture in elderly patients with initial hip fractures. Data Sources: This search was applied to Medline, Embase, Cochrane central database (all up to April 2014). Methods: All the studies on bilateral hip fractures in elderly patients published in English were reviewed and qualities of included studies were assessed using the Newcastle-Ottawa Scale. All the data were carefully and independently abstracted by two reviewers, any disagreement was settled by discussion. Data was pooled and a meta-analysis completed. Results: A total of 13 case-control studies were identified for the meta-analysis. The significant risk factors were female (odds ratio (OR), 1.30; 95% confidence interval (CI), 1.02-1.64), living in institutions (OR, 2.53; 95% CI, 1.33-4.85), osteoporosis (OR, 10.02; 95% CI, 5.41-18.57), low vision (OR, 2.09; 95% CI, 1.06-4.12), dementia (OR, 2.02; 95% CI, 1.54-2.65), dizziness (OR, 2.87; 95% CI, 1.42-5.87) cardiac diseases (OR, 1.33; 95% CI, 1.00-1.78) and respiration diseases (OR, 2.58; 95% CI, 1.22-5.47). No significant difference was found in admission age between patients with the unilateral hip fracture and the first hip fracture of bilateral hip groups (standardized mean difference, 0.02, 95% CI, -0.30 to 0.35]. Conclusions: Patients involved with female, living in institutions, osteoporosis, low vision, dizziness, dementia, respiration diseases and cardiac diseases were at risk for a second contralateral hip fracture after the initial hip fracture. © The Author(s) 2014.


Zhu Y.,Hebei Medical University | Zhu Y.,Key Laboratory of Biomechanics of Hebei Province | Chen W.,Hebei Medical University | Chen W.,Key Laboratory of Biomechanics of Hebei Province | And 8 more authors.
Archives of Gerontology and Geriatrics | Year: 2014

This study aims to quantitatively summarize the risk factors for the incidence of SHF. A meta-analysis was performed with the data obtained from 22 relevant papers published in Pubmed, Embase and Cochrane central database (all through January 2014) following strict selection. The pooled odds ratios (ORs) or standardized mean difference (SMD) with 95% confidence intervals (CIs) were calculated for potential risk factors associated with SHF. Our meta-analysis indicated the significant risk factors for SHF were female (OR, 1.46; 95%CI, 1.29-1.66), living in institutions (OR, 2.23; 95%CI, 1.29-3.83), osteoporosis (Singh index (SI) 1-3) (OR, 10.02; 95%CI, 5.41-18.57), low vision (OR, 2.09; 95%CI, 1.06-4.12), dementia (OR, 1.89; 95%CI, 1.47-2.43), Parkinson (OR, 2.90; 95%CI, 1.41-5.95), cardiac diseases (OR, 1.32; 95%CI, 1.02-1.70) and respiratory disease (OR, 1.97; 95%CI, 1.16-3.32). Related strategies must be implemented on those involved with above-mentioned medical conditions to effectively prevent a SHF. © 2014 Elsevier Ireland Ltd.


Zhu Y.,Hebei Medical University | Zhu Y.,Key Laboratory of Biomechanics of Hebei Province | Zhang F.,Hebei Medical University | Zhang F.,Key Laboratory of Biomechanics of Hebei Province | And 8 more authors.
Archives of Orthopaedic and Trauma Surgery | Year: 2015

Background: This study aims to quantitatively summarize risk factors associated with heterotopic ossification after total hip arthroplasty. Methods: The computerized and additional manual searches were performed in Medline, Embase, CNKI, and Cochrane central database (all through March 2014) for potential studies. Studies eligible had to meet the quality assessment criteria by Newcastle–Ottawa Scale and to evaluate the risk factors for heterotopic ossification after total hip arthroplasty. Two reviewers independently extracted the relevant data and any disagreement was solved by consensus. Stata11.0 was used to perform all the statistical analyses. Results: Fourteen studies involving 6468 cases with total hip arthroplasty and 1939 heterotopic ossification (HOs) (30.0 %) were eligible and included in this meta-analysis. Our meta-analysis identified the significant increased risk factors for HO were male gender [odds ratio (OR) 2.11; 95 % confidence interval (CI) 1.80–2.48)], cemented implant (OR 1.48; 95 % CI 1.00–2.17), bilateral operations (OR 1.74; 95 % CI 1.24–2.45), ankylosing spondylitis (OR 1.90; 95 % CI 1.07–3.37) and ankylosed hip (OR 9.85; 95 % CI 2.61–37.24). Rheumatoid arthritis was protective for the development of HO (OR 0.51; 95 % CI 0.33–0.80). The other variables including age, use of NSAIDs, femoral neck fracture, previous hip fracture, hypertrophic osteoarthritis and osteophytes were identified not as the risk factors for development of HO (P > 0.05). Conclusion: Patients involved with the above-mentioned medical conditions should be carefully paid close attention by surgeons to reduce HO after total hip arthroplasty. Level of evidence: Level II, meta-analysis. © 2015, Springer-Verlag Berlin Heidelberg.


Tian Y.,Hebei Medical University | Tian Y.,Key Laboratory of Biomechanics of Hebei Province | Zhu Y.,Hebei Medical University | Zhu Y.,Key Laboratory of Biomechanics of Hebei Province | And 10 more authors.
International Orthopaedics | Year: 2016

Purpose: The purpose of this study was to investigate the age- and gender-specific clinical characteristics of adult spine fractures in China. Method: A retrospective investigation was performed on consecutive patients with acute spinal fractures in 83 hospitals of 31 provinces in China between January 2010 and December 2011. All adult patients (≥16 years) with spinal column fracture were included, while pathologic, old, and periprosthetic fractures were excluded. Each patient was analysed by reviewing the medical records and initial radiographs. Results: There were 54,533 adult patients with spinal column fractures, accounting for 14.57 % of overall fractures. The medium age was 57 years (range 16–100 years). There were 27,466 male patients with medium age of 49 years and 27,067 females with medium age of 63 years. The male to female ratio was 1.01:1 in study. It was 1.74:1 in patients less than 59 years, and 0.51:1 above 60 years. The most common injury site was L1, which accounted for 33.83 % of cases. In the AO classification, the 53A and 52A groups comprised 85.53 % of all fractures. Conclusions: This study demonstrates the age- and gender-specific clinical characteristics of adults spine fractures and reveals a significant relationship among ages, sex, fracture localisation and complexity of spine fractures. Using the age of patients, the likelihood of sustaining adult spine fractures is predictable. © 2015, SICOT aisbl.


PubMed | Key Laboratory of Biomechanics of Hebei Province
Type: Journal Article | Journal: International orthopaedics | Year: 2015

The purpose of this study was to examine calcitonin gene-related peptide (CGRP) concentrations in serum and synovial fluid of patients with primary knee osteoarthritis (OA) and healthy controls and to explore their relationship with clinical and radiographic severity of OA.Sixty-five patients with primary knee OA and 21 healthy controls were recruited. CGRP concentrations in the serum and synovial fluid were measured using enzyme-linked immunosorbent assays. The radiographic severity of OA was evaluated using the Kellgren and Lawrence (KL) classification. The Western Ontario and McMaster University Osteoarthritis Index (WOMAC) was used to assess pain, stiffness and physical function.Serum and synovial fluid CGRP concentrations tended to be higher with the increase in KL grades (r=0.565 and r=0.441, P<0.001, respectively), and were significantly positively correlated with KL grades, total WOMAC score and each subscale (pain, stiffness and physical function).The result demonstrated that CGRP in serum and synovial fluid was related to progressive joint damage in knee OA. CGRP can be selected as a biomarker for monitoring disease severity and could be a predictive role on prognosis and progression of knee OA.


Yang Y.,Hebei Medical University | Wang J.,Hebei Medical University | Sun J.,Hebei Medical University | Liu L.,Hebei Medical University | And 3 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2016

This meta-analysis of randomised controlled trials (RCTs) aimed to investigate the comparative outcomes between hemiarthroplasty (HA) and internal fixation (IF) for management of displaced femoral neck fractures. Relevant original studies were searched in electronic databases of Embase, CNKI, Medline, and Cochrane central database (all through October 2015). RCTs that investigated the effectiveness or complications between both groups and provided sufficient data of interest were included in this meta-analysis. 14 RCTs fulfilled inclusion and exclusion criteria and were included in this meta-analysis, with 1270 participants in the IF group and 1425 in the HA group. Patients were followed up for at least one year in all the studies. Compared to IF, HA is a better alternative for treatment of displaced femoral neck fracture in the elderly, with reduced major complications and reoperations, better hip pain relief and favorable hip function in the long run. There were no statistically significant differences between the groups in the incidence of wound infection, deep vein thrombosis, pulmonary embolism, haematoma, pressure sores, cerebrovascular accident, respiratory infection and urinary tract infection. HA has more advantages than IF for treatment of displaced femoral neck fracture, and could be a better alternative if surgery was indicated. This definitive conclusion could help surgeons in making evidence-based decisions when selecting an optimal fixation pattern. © 2016, E-Century Publishing Corporation. All rights reserved.


Dong T.,Key Laboratory of Biomechanics of Hebei Province | Dong T.,Hebei Medical University | Chang H.,Key Laboratory of Biomechanics of Hebei Province | Chang H.,Hebei Medical University | And 10 more authors.
International Orthopaedics | Year: 2015

Purpose: The purpose of this study was to examine calcitonin gene-related peptide (CGRP) concentrations in serum and synovial fluid of patients with primary knee osteoarthritis (OA) and healthy controls and to explore their relationship with clinical and radiographic severity of OA. Methods: Sixty-five patients with primary knee OA and 21 healthy controls were recruited. CGRP concentrations in the serum and synovial fluid were measured using enzyme-linked immunosorbent assays. The radiographic severity of OA was evaluated using the Kellgren and Lawrence (KL) classification. The Western Ontario and McMaster University Osteoarthritis Index (WOMAC) was used to assess pain, stiffness and physical function. Results: Serum and synovial fluid CGRP concentrations tended to be higher with the increase in KL grades (r = 0.565 and r = 0.441, P < 0.001, respectively), and were significantly positively correlated with KL grades, total WOMAC score and each subscale (pain, stiffness and physical function). Conclusions: The result demonstrated that CGRP in serum and synovial fluid was related to progressive joint damage in knee OA. CGRP can be selected as a biomarker for monitoring disease severity and could be a predictive role on prognosis and progression of knee OA. © 2015, SICOT aisbl.

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