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Feng X.-Y.,Institute of Chemical Industry of Forestry Products | Feng X.-Y.,Key Laboratory of Biomass Energy and MaterialJiangsu Province | Feng X.-Y.,National Engineering Laboratory for Biomass Chemical Utilization China | Feng X.-Y.,Key and Open Laboratory on Forest Chemical Engineering | And 16 more authors.
Chinese Journal of Inorganic Chemistry | Year: 2015

Gold nanorods (GNR) with longitudinal surface plasma resonance (LSPR) absorption at 785 nm were synthesized by seed-mediated growth method and their surface was modified with polyethylene glycol (PEG) macromolecular (PEG-GNR). The photothermal conversion effect and cytotoxicity of PEG-GNR were investigated. Different bacteria, including gram-positive bacterium Staphylococcus aureus and Bacillus cereus, gram-negative bacterium Escherichia coli and Pseudomonas aeruginosa were used to analyze the influences of concentration of PEG-GNR and laser output power on the inhibition effects. The results show that the PEG-GNR has good antibacterial properties for both Gram positive and negative bacterium under the radiation of near-IR laser. The concentration of PEG-GNR and laser output power determined antibacterial effects of the PEG-GNR. The preliminary investigation on the antibacterial mechanism was explored by studying of bacteria apoptosis status with fluorescence microscope and transmission electronic microscope, suggesting that the effective absorption of the PEG-GNR by the cells is one of the key factors in the process of photothermal antibiosis. © 2015, Chinese Chemical Society.All Rights Reserved.

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