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Rui J.,Nanjing Forestry University | Yang J.,Nanjing Forestry University | Huang J.,Nanjing Forestry University | Wang J.,Nanjing Forestry University | And 7 more authors.
Chinese Journal of Organic Chemistry | Year: 2016

A series of new isolongifolanonyl pyrazole derivatives 3a~3j were synthesized by aldol-condensation, cyclization and dehydroaromatization from isolongifolanone. The yields of products ranged from 69.5% to 76.5%. The chemical structures of compounds obtained were elucidated by 1H NMR, 13C NMR, IR, MS spectra and elemental analysis. The strucure of compound 3i was determined by X-ray single crystal diffraction. Their inhibitory activities against human hepatoma cell (HepG2) and human umbilical vein endothelial cell (HUVECs) were evaluated. The results indicated that compounds 3h and 3i[IC50=(15.42±0.6), (4.74±0.3) μmol/L] showed obvious inhibitory activity against HUVECs. Compounds 3a, 3c,3e and 3j[IC50=(5.27±0.5), (6.71±0.4), (4.68±0.2), (4.57±0.5)] μmol/L showed better antitumor activity against HepG2. © 2016 Chinese Chemical Society & SIOC, CAS.

Wu G.-M.,CAF Institute of Chemical Industry of Forest Products | Wu G.-M.,Key Laboratory of Biomass Energy and Material of Jiangsu Province | Wu G.-M.,Key and Open Laboratory on Forest Chemical Engineering | Wu G.-M.,National Engineering Laboratory for Biomass Chemical Utilization | And 20 more authors.
Thermochimica Acta | Year: 2013

The crosslinking reaction kinetics of two-component waterborne polyurethanes (2K-WPUs) composed of cationic polyol dispersions and hydrophilically modified hexamethylene diisocyanate (HDI) tripolymer were investigated by differential scanning calorimetry (DSC) and dielectric analysis (DEA) techniques. DSC data fit for the 2K-WPUs was carried out with Málek's mechanism function method. The kinetic parameters and kinetic models of crosslinking reaction were determined by the kinetic analysis with Málek's method. The result showed that the crosslinking process of the reaction followed an autocatalytic reaction. Sestak-Berggren model (S-B model) could favorably describe the crosslinking reaction process of the studied 2K-WPUs. The reaction rate curves derived from the experimental data showed a good agreement with the theoretical calculation under 5-20 °C min -1 heating rate. Isothermal DSC and DEA of the crosslinking process of the 2K-WPUs were used to confirm the obtained kinetics equations. The conversion-time curves from isothermal DSC matched favorably with the calculated curves from the obtained kinetic equations, and the log ion viscosity-time curves from isothermal DEA matched roughly with the conversion-time curves from DSC. © 2012 Elsevier B.V. All rights reserved.

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