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Zhang Q.,Shandong University | Zhang Q.,National Research Center for Assisted Reproductive Technology and Reproductive Genetics | Zhang Q.,The Key Laboratory for Reproductive Endocrinology of Ministry of Education | Zhang Q.,Shandong Provincial Key Laboratory of Reproductive Medicine | And 4 more authors.
Reproductive Medicine and Biology | Year: 2015

Embryonic development into an implantation-competent blastocyst, synchronized uterine transformation into a receptive stage, and an intimate cross-talk between the activated blastocyst and the receptive uterus are essential for successful implantation, and therefore for subsequent pregnancy outcome. Evidence accumulating during recent years has underlined the importance of the Wnt signaling pathway in mammalian implantation and decidualization. Herein, this review focuses on the current state of knowledge regarding Wnt signaling in multiple implantation and decidualization events: pre-implantation embryo development, blastocyst activation for implantation, uterine development, and decidualization. © 2015 Japan Society for Reproductive Medicine Source


Zhao H.,Shandong University | Zhao H.,National Research Center for Assisted Reproductive Technology | Zhao H.,The Key Laboratory for Reproductive Endocrinology of Ministry of Education | Zhao H.,Shandong Provincial Key Laboratory of Reproductive Medicine | And 5 more authors.
Molecular Human Reproduction | Year: 2013

Many genetic association studies have been performed to investigate disorders of female reproduction, such as polycystic ovary syndrome, premature ovarian failure and endometriosis. These disorders typically manifest heterogeneously, and their pathogeneses are influenced by polygenic and environmental factors. Researchers evaluating these genetic associations have chosen candidate genes related to hormone action, steroid biosynthesis, inflammatory cytokines and autoimmune factors. Several of these genes have yielded statistically significant associations with female reproductive disorders; however, few associations have been robust and reproducible. Whole-genome association studies generate more reliable and unbiased results and represent a breakthrough in genetic studies of female reproduction. Nevertheless, to date only a very small fraction of the overall heritability has been identified and so further studies are needed. © The Author 2013. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. Source


Zhao H.,Shandong University | Zhao H.,National Research Center for Assisted Reproductive Technology and Reproductive Genetics | Zhao H.,The Key Laboratory for Reproductive Endocrinology of Ministry of Education | Lv Y.,Shandong University | And 10 more authors.
Best Practice and Research: Clinical Obstetrics and Gynaecology | Year: 2016

Polycystic ovary syndrome (PCOS) is a highly heterogeneous reproductive system disorder of which the aetiology is not fully understood. Previous association studies have been conducted on >100 candidate genes, which principally related to reproductive hormones, cellular metabolism and chronic inflammation. Heritable tendencies have long been recognized for pathogeneses of PCOS, and recently a genome-wide association study (GWAS) in PCOS provides new clues to understand the genetic components and pathways in PCOS physiology. However, the current knowledge of the pathogenesis of PCOS is still in its infancy. Further studies using new technologies such as next-generation sequencing (NGS) shall be useful to understand more causal variants for PCOS. © 2016. Source


Li T.,Shandong University | Li T.,National Research Center for Assisted Reproductive Technology | Li T.,The Key Laboratory for Reproductive Endocrinology of Ministry of Education | Li T.,Shandong Provincial Key Laboratory of Reproductive Medicine | And 29 more authors.
Journal of Medical Genetics | Year: 2012

Background: A previously reported genome-wide association study (GWAS) of polycystic ovary syndrome (PCOS) in Han Chinese found that several loci of p value around 10e-5 warrant investigation. Replication of the GWAS was applied in this study to determine whether gene YAP1 (yeast associated protein 1) is associated with PCOS. Methods: An independent set of 1115 PCOS patients and 1137 controls were recruited; single nucleotide polymorphisms (SNPs) rs11225138, rs11225161, and rs11225166 from YAP1 were selected for the replication study. Real-time quantitative PCR was applied for genotyping by TaqMan-MGB probe assay. Results: Meta-analysis showed that the allele frequency of rs11225161 (A/G) was significantly different between PCOS and controls at a GWA significance (Pmeta =3.98e 09). Genotype-phenotype correlation study found 30 min and 60 min glucose of the oral glucose tolerance test were higher in PCOS patients with rs11225161 risk allele A. The G allele of SNP rs11225138 (G/C) was a further risk factor for higher luteinising hormone level in PCOS patients (p=0.041). Conclusion: YAP1 appears to be a new susceptibility gene for PCOS in Han Chinese women. Source


Zhang B.,Shandong University | Zhang B.,National Research Center for Assisted Reproductive Technology and Reproductive Genetics | Zhang B.,The Key Laboratory for Reproductive Endocrinology of Ministry of Education | Zhang B.,Shandong Provincial Key Laboratory of Reproductive Medicine | And 20 more authors.
PLoS ONE | Year: 2012

Background: Previous genome-wide association study (GWAS) of polycystic ovary syndrome (PCOS) in Han Chinese population has found that SNPs in LPP gene were nominally significant in PCOS patients (P around 10E-05). Replication of the GWAS was applied to further confirm the relationship between LPP gene and PCOS. Methods: Three polymorphisms of LPP gene (rs715790, rs4449306, rs6782041) were selected and replicated in additional 1132 PCOS cases and 1142 controls. Genotyping of LPP gene was carried out by Taqman-MGB method. Results: In rs715790, the allele frequency is significantly different between the PCOS group and the control group. Meta-analysis showed that the allele frequencies of the three SNPs rs715790 (Pmeta = 1.89E-05, OR = 1.23), rs4449306 (Pmeta = 3.0E-04, OR = 1.10), rs6782041 (Pmeta = 2.0E-04, OR = 1.09), were significantly different between PCOS cases and controls. Conclusions: Our results suggest that LPP gene might be a novel candidate for PCOS. © 2012 Zhang et al. Source

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