The Key Laboratory for Mental Health

Beijing, China

The Key Laboratory for Mental Health

Beijing, China
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Dai Y.,Shanghai JiaoTong University | Yu X.,Peking University | Yu X.,The Key Laboratory for Mental Health | Xiao Z.,Shanghai JiaoTong University | And 6 more authors.
Asia-Pacific Psychiatry | Year: 2014

Introduction: This study aimed to explore the views and attitudes of Chinese psychiatrists on mental disorders classification, and to compare their similarities and differences with those of the international mental health professionals. Methods: Two hundred and ninety members of the Chinese Society of Psychiatry were invited to participate in the study and 211 completed the survey. Results: Ninety-one percent of Chinese participants regularly used a formal classification system, with more users of the International Classification of Diseases 10th Revision (ICD-10; 48.8%) or Chinese Classification of Mental Disorders 3rd Edition (39.3%) than the 4th Edition of Diagnostic and Statistical Manual (11.4%). Like their global counterparts, Chinese respondents regarded communication among clinicians as the most important purpose of a classification and preferred a simpler system with fewer categories. Chinese psychiatrists were more likely than international participants to prefer a system with strict diagnostic criteria for all disorders and to endorse problems with a cultural applicability of the classification. However, only a minority (31.3%) indicated that they saw a need for a national classification. Discussion: Overall, Chinese psychiatrists have similar opinions and attitudes on most issues of the classification to the international clinicians. Areas of divergent views may provide meaningful information for ICD revision in China. © 2014 Wiley Publishing Asia Pty Ltd.

Wang L.,Peking University | Wang L.,The Key Laboratory for Mental Health | Dai W.,Peking University | Dai W.,The Key Laboratory for Mental Health | And 12 more authors.
PLoS ONE | Year: 2012

Background: Resting-state fMRI is a novel approach to measure spontaneous brain activity in patients with major depressive disorder (MDD). Although most resting-state fMRI studies have focused on the examination of temporal correlations between low-frequency oscillations (LFOs), few studies have explored the amplitude of these LFOs in MDD. In this study, we applied the approaches of amplitude of low-frequency fluctuation (ALFF) and fractional ALFF to examine the amplitude of LFOs in MDD. Methodology/Principal Findings: A total of 36 subjects, 18 first-episode, treatment-naive patients with MDD matched with 18 healthy controls (HCs) completed the fMRI scans. Compared with HCs, MDD patients showed increased ALFF in the right fusiform gyrus and the right anterior and posterior lobes of the cerebellum but decreased ALFF in the left inferior temporal gyrus, bilateral inferior parietal lobule, and right lingual gyrus. The fALFF in patients was significantly increased in the right precentral gyrus, right inferior temporal gyrus, bilateral fusiform gyrus, and bilateral anterior and posterior lobes of the cerebellum but was decreased in the left dorsolateral prefrontal cortex, bilateral medial orbitofrontal cortex, bilateral middle temporal gyrus, left inferior temporal gyrus, and right inferior parietal lobule. After taking gray matter (GM) volume as a covariate, the results still remained. Conclusions/Significance: These findings indicate that MDD patients have altered LFO amplitude in a number of regions distributed over the frontal, temporal, parietal, and occipital cortices and the cerebellum. These aberrant regions may be related to the disturbances of multiple emotion- and cognition-related networks observed in MDD and the apparent heterogeneity in depressive symptom domains. Such brain functional alteration of MDD may contribute to further understanding of MDD-related network imbalances demonstrated in previous fMRI studies. © 2012 Wang et al.

Wang L.,Peking University | Wang L.,The Key Laboratory for Mental Health | Li K.,306 Hospital of Peoples Liberation Army | Zhang Q.-E.,Capital Medical University | And 12 more authors.
PLoS ONE | Year: 2013

Background: Abnormalities in large-scale, structural and functional brain connectivity have been increasingly reported in patients with major depressive disorder (MDD). However, MDD-related alterations in functional interaction between the cerebral hemispheres are still not well understood. Resting state fMRI, which reveals spontaneous neural fluctuations in blood oxygen level dependent signals, provides a means to detect interhemispheric functional coherence. We examined the resting state functional connectivity (RSFC) between the two hemispheres and its relationships with clinical characteristics in MDD patients using a recently proposed measurement named "voxel-mirrored homotopic connectivity (VMHC)". Methodology/Principal Findings: We compared the interhemispheric RSFC, computed using the VMHC approach, of seventeen first-episode drug-naive patients with MDD and seventeen healthy controls. Compared to the controls, MDD patients showed significant VMHC decreases in the medial orbitofrontal gyrus, parahippocampal gyrus, fusiform gyrus, and occipital regions including the middle occipital gyrus and cuneus. In MDD patients, a negative correlation was found between VMHC of the fusiform gyrus and illness duration. Moreover, there were several regions whose VMHC showed significant negative correlations with the severity of cognitive disturbance, including the prefrontal regions, such as middle and inferior frontal gyri, and two regions in the cereballar crus. Conclusions/Significance: These findings suggest that the functional coordination between homotopic brain regions is impaired in MDD patients, thereby providing new evidence supporting the interhemispheric connectivity deficits of MDD. The significant correlations between the VMHC and clinical characteristics in MDD patients suggest potential clinical implication of VMHC measures for MDD. Interhemispheric RSFC may serve as a useful screening method for evaluating MDD where neural connectivity is implicated in the pathophysiology. © 2013 Wang et al.

Sheng J.,Shanghai JiaoTong University | Zhu Y.,Shanghai JiaoTong University | Lu Z.,Shanghai JiaoTong University | Lu Z.,Tongji University | And 7 more authors.
Schizophrenia Research | Year: 2013

Neuroanatomical abnormalities are considered to be related to the pathogenesis of schizophrenia. Reversal or reduction of normal structural cerebral asymmetries in schizophrenia is particularly striking. The current study investigated the alteration of gray matter volume and cerebral asymmetry in early stage of first-episode schizophrenia (FESZ), and their correlations with clinical measures. Magnetic resonance imaging scans were obtained from a total of 89 participants. Thirty-three FESZ patients and 41 matched healthy controls were included in the analysis. Compared to healthy controls, the FESZ patients showed decreased gray matter volume (GMV) in the frontal cortex, anterior cingulate cortex, temporal cortex, parahippocampal, fusiform, insula, and lingual; and increased GMV in cerebellum. Both male and female patients displayed an increased rightward lateralization in frontal and temporal cortex, which was significantly correlated with the severity of symptoms and social functioning. These findings may provide the neurological substrate for the etiology and clinical manifestations of the illness. © 2013 Elsevier B.V.

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