Wang S.,Chinese Peoples Liberation Army |
Xue H.,Sino German Laboratory for Molecular Medicine |
Zou Y.,Key Laboratory For Clin Cardiovasc Genet Of Min Of Educ Cardiovascular Institute And Fu Wai Hospital |
Sun K.,Key Laboratory For Clin Cardiovasc Genet Of Min Of Educ Cardiovascular Institute And Fu Wai Hospital |
And 3 more authors.
Hypertension Research | Year: 2014
Our study aimed to explore whether left ventricular hypertrophy (LVH), abnormal LV geometry and relative wall thickness (RWT) are associated with an increased risk of stroke in a hypertensive Chinese population. This study included 462 stroke patients and 3808 non-stroke hypertensive patients. LVH was diagnosed using the criteria of LV mass ≥49.2 g m -2.7 for men and 46.7 g m -2.7 for women. A partition value of 0.43 was used for RWT. LV geometric patterns (normal, concentric remodeling, concentric or eccentric hypertrophy) were calculated according to LVH and RWT. Logistic regression analyses were used to determine the odds ratio (OR) and 95% confidence intervals (CI) of LVH, LV geometry abnormality and RWT for stroke. Our study suggested that LVH was associated with increased stroke risk (adjusted OR, 1.52; 95% CI, 1.25-1.85; multivariate-Adjusted OR, 1.43; 95% CI, 1.16-1.75) and that concentric hypertrophy carried the highest risk of stroke (adjusted OR, 1.62; 95% CI, 1.21-2.17), followed by eccentric hypertrophy (adjusted OR, 1.51; 95% CI, 1.12-2.03), with concentric remodeling ranked third (adjusted OR, 1.34; 95% CI, 1.01-1.80). RWT was associated with an increased risk of stroke and was independent of LVMI and other risk factors for stroke (adjusted OR, 3.97; 95% CI, 1.10-14.34). Our observations in Chinese patients with hypertension indicated that LVH was an important risk factor for stroke, LV geometry abnormality was related to the presence of stroke, concentric hypertrophy carried the highest risk of stroke in cases of abnormal LV geometry and that RWT was also a risk factor for stroke and was independent of LVMI and other stroke risk factors. copy; 2014 The Japanese Society of Hypertension All rights reserved.