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Zeng T.,Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety | Zeng T.,National Center for Nanosciences and Technology of China | Li T.,Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety | Li Y.,Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety | And 7 more authors.
Nanoscale | Year: 2014

We report single-molecule detection of Hg2+ by threading an Hg2+-mediated DNA duplex through α-hemolysin nanopores, which generates characteristic three-level current patterns and enables the unambiguous detection of Hg2+. This strategy precludes any background interference and features high sensitivity and selectivity. Moreover, the platform could be readily integrated with aptamers and molecular beacons, offering extended possibilities for the construction of a new DNA-based nanopore sensing system. This journal is © the Partner Organisations 2014. Source

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