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Feng L.,Sichuan Agricultural University | Feng L.,Key Laboratory for Animal Disease resistance | Xiao W.-W.,Sichuan Agricultural University | Liu Y.,Sichuan Agricultural University | And 10 more authors.
Aquaculture Nutrition | Year: 2011

Oxidative damage and antioxidant status of intestine and hepatopancreas for juvenile Jian carp (Cyprinus carpio var. Jian) fed graded levels of methionine hydroxy analogue (MHA: 0, 5.1, 7.6, 10.2, 12.7, 15.3g kg-1 diet) for 60days were studied. Radical scavenging ability, antioxidant enzymes activities such as superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reducase (GR), as well as glutathione (GSH), protein carbonyl (PC) and malondialdehyde (MDA) contents were assayed in these tissues. Results indicated that anti-superoxide anion capacity in intestine and anti-hydroxyl radical capacity in hepatopancreas significantly improved with dietary MHA levels up to 7.6 and 10.2g kg-1 diet respectively, whereupon they decreased (P<0.05). SOD, CAT, GST, GPX, GR activities in intestine and hepatopancreas, as well as GSH content in hepatopancreas significantly increased with optimal MHA levels which were in the range of 5.1-10.2g kg-1 diet, and thereafter decreased (P<0.05). Meanwhile, MDA and PC contents in these tissues together with GOT and GPT activities in plasma significantly decreased with optimal MHA levels which were in the range of 5.1-7.6g kg-1 diet, and thereafter increased (P<0.05). These results suggested that MHA improved antioxidant status and depressed lipid and protein oxidation in intestine and hepatopancreas. © 2011 Blackwell Publishing Ltd. Source

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