Defense Key Disciplines Laboratory of Novel Micro Nano Devices and System Technology

Chongqing, China

Defense Key Disciplines Laboratory of Novel Micro Nano Devices and System Technology

Chongqing, China
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Zou H.L.,Southwest University | Li B.L.,Southwest University | Luo H.Q.,Southwest University | Li N.B.,Southwest University | Li N.B.,Defense Key Disciplines Laboratory of Novel Micro nano Devices and System Technology
Sensors and Actuators, B: Chemical | Year: 2017

Recently, hybrids of layered MoS2 are highly encouraged to handle the puzzles, taken by the weakness of two-dimensional (2D) transition metal dichalcogenides (TMDC), including low conductivity and lack of active edge sites. Considering the merits of zero-dimensional (0D) nanomaterials, the emerging heterostructures based on 0D Au nanoparticles and 2D MoS2nanosheets (MoS2-NSs) are successfully obtained via a spontaneously reduced process with the addition of HAuCl4 in exfoliated MoS2-NSs aqueous dispersions. Significantly, with the combination of high conductivity rate and large active surface, the synthetic effect results in a diversity of improved properties of 0D-2D heterostructures, not only exhibiting improved stability, but also remarkably enhancing the selectivity and sensitivity for electrochemically simultaneous detections of dopamine, ascorbic acid, uric acid, and nitrite. Our current achievements of 0D-2D heterostructures contribute fresh ideas to the overall development of more advanced future TMDC based sensors. © 2017 Elsevier B.V.


Zhang Q.,Chongqing University | Zhang Q.,Defense Key Disciplines Laboratory of Novel Micro nano Devices and System Technology | Xu Y.,Chongqing University | Xu Y.,Defense Key Disciplines Laboratory of Novel Micro nano Devices and System Technology | And 8 more authors.
Carbohydrate Polymers | Year: 2016

The alkali-extractable polysaccharides (APMPs) were isolated from the water extracted residues of Radix Polygoni Multiflori, and further purified by DEAE-52 cellulose and Sephadex G-100 column chromatography to obtain a homogeneous polysaccharide (APMP-2) with molecular weights of 7724.8 Da. HPLC chromatography analysis identified that APMP-2 was a heteropolysaccharides and mainly composed of Galactose and Xylose with a molar ratio of 4.31: 1.06. It was shown that both APMP and APMP-2 were of activation effects on splenocytes and peritoneal macrophages, and also significantly restore the proliferation rate, phagocytic index and cytokine (IL-2 and TNF-α) production level of 5-FU-treated splenocytes/peritoneal macrophages in a dosage-dependent manner. The results suggested that polysaccharides presented in Radix Polygoni Multiflori water-extracted residues possessed immunomodulatory activity and could be used as potential immunomodulators, and this finding could be a reference for the utilization of Radix Polygoni Multiflori water extracted residues. © 2015 Elsevier Ltd. All rights reserved.


Su X.,Chongqing University | Xu Y.,Chongqing University | Xu Y.,Defense Key Disciplines Laboratory of Novel Micro Nano Devices and System Technology | Che Y.,Chongqing University | And 2 more authors.
Journal of Biomedical Materials Research - Part A | Year: 2015

A new type of multifunctional fluorescent magnetic carbon quantum dots SPIO@CQDs( n ) ([superparamagnetic iron oxide nanoparticles (SPIO), carbon quantum dots, (CQDs)]) with magnetic and fluorescence properties was designed and prepared through layer-by-layer self-assembly method. The as-synthesized SPIO@CQDs( n ) exhibited different emission colors including blue, green, and red when they were excited at different excitation wavelengths, and its fluorescent intensity increased as the increase of CQD layer (n). SPIO@CQDs( n ) with quite low toxicity could mark cytoplasm with fluorescence by means of nonimmune markers. The mixture sample of liver cells L02 and hepatoma carcinoma cells HepG2 was taken as an example, and HepG2 cells were successfully separated and detected effectively by SPIO@CQDs( n ), with a separation rate of 90.31%. Importantly, the designed and prepared SPIO@CQDs( n ) are certified to be wonderful biological imaging and magnetic separation regents. © 2015 Wiley Periodicals, Inc.


Zhao H.-Z.,Chongqing University | Zhao H.-Z.,Defense Key Disciplines Laboratory of Novel Micro nano Devices and System Technology | Xu Y.,Chongqing University | Xu Y.,Defense Key Disciplines Laboratory of Novel Micro nano Devices and System Technology | And 8 more authors.
RSC Advances | Year: 2016

A "sandwich" microfluidic surface enhanced Raman scattering (SERS) chip with Ag film@nanoAu prepared in a microchannel was proposed and fabricated in situ. The integrated composite Ag film@nanoAu was prepared in situ by way of chemical plating and self-assembly. Firstly, the preparation conditions were optimized. On the basis of that, the influence of the laser focus position along the vertical direction and the materials of the cover plates on the SERS effect were investigated and optimized in detail. The optimized SERS effect was observed when the laser was focused on the interface of the sample and the SERS substrate. The SERS intensity of Rhodamine 6G (R6G) decreased 2.5 times and 2.1 times when PDMS or glass was used as the cover plate separately. Compared to single gold and silver SERS substrates, the composite of Ag film@nanoAu integrated in the microfluidic channel resulted in the peak intensity increasing 3-5 times during the SERS detection of R6G at 1507 cm-1. The enhancing effect could be attributed to the change in the local electromagnetic field which was caused by the synergistic sensitizing effect between the Au nanoparticles and the underlying silver mirror film. It was illustrated that the detection limit for R6G was 10-8 M and the enhancement factor (EF) was 3.8 × 105 with a relative standard deviation (RSD) of approximately 10% in the as-prepared microfluidic SERS chip. © The Royal Society of Chemistry 2016.


Zhang X.,Chongqing University | Zhang X.,Chongqing University of Technology | Zhang X.,Defense Key Disciplines Laboratory of Novel Micro nano Devices and System Technology | Xu Y.,Chongqing University | And 5 more authors.
Materials and Design | Year: 2016

The functional absorbents modified by hydroxyl, phenolic hydroxyl, resorcinol and hydroquinone were designed and prepared to purify stilbene glucoside from Polygonum multiflorum root. It is noted that the adsorption capacity and retention behavior of functional absorbents to stilbene glucoside depended on the specific surface area, hydrophilia and better geometrical matching between absorbate and spatial structure of absorbents micropore. In addition, the hydrophilia and better geometrical matching can make functional absorbents exhibit excellent selective adsorption performance. Thus, except for conventional hydrophilia and the specific surface area, better geometrical matching between absorbate and spatial structure of absorbent micropore should be considered as an important factor in design functional absorbents. These results provided new insight into the design of functional absorbents for efficient isolation and purification of complex product. © 2015 Elsevier Ltd.


Gan J.,Chongqing University | Gan J.,Defense Key Disciplines Laboratory of Novel Micro nano Devices and System Technology | Xu Y.,Chongqing University | Xu Y.,Defense Key Disciplines Laboratory of Novel Micro nano Devices and System Technology | And 7 more authors.
Gongneng Cailiao yu Qijian Xuebao/Journal of Functional Materials and Devices | Year: 2011

Two-dimensional microfluidic chip electrophoresis technology has shown great potential in the study of complex proteomics because of its advantages, such as fast separation speed, easy miniaturization and automation, lower dead volume at the interface, high peak capacity and resolution, and so on. In this paper, the principles of two-dimensional protein microfluidic chip electrophoresis, the chip design and fabrication, detecting method, optimizing conditions of separation and analysis were summarized. According to two-dimensional interface modes, the research and the latest developments of the two-dimensional microfluidic chip electrophoresis in protein separation and analysis were reviewed. At last, the application prospects of two-dimensional microfluidic chip electrophoresis in the proteomics research was also discussed.

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