Kewpie Corporation

Fuchū, Japan

Kewpie Corporation

Fuchū, Japan

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Patent
Kewpie Corporation and University of Tsukuba | Date: 2017-01-11

Hyaluronic acid modified with sphingosine-1-phosphoate, and a medicine comprising the hyaluronic acid as an active ingredient, wherein the medicine can alleviate hepatic disorder caused by hypoxia/reoxygenation by protecting the liver sinusoidal endothelial cells, and the medicine can prevent and/or treat liver failure due to liver transplantation, hepatectomy, or other surgeries associated with liver ischemia/reperfusion.


Patent
Kewpie Corporation | Date: 2017-02-08

There is provided an enzyme preparation capable of effectively removing C1-C10 aldehydes. The enzyme preparation includes as an active ingredient a composite of aldehyde dehydrogenase produced by acetic acid bacteria of the genus Gluconacetobacter and cell membranes with which the aldehyde dehydrogenase combines. The enzyme preparation has a pH of 4 to 7. An activity of the aldehyde dehydrogenase per 0.006 mg of protein obtainable from the acetic acid bacteria is represented as absorbance (660 nm) of an aqueous solution (3.9 mL) of ferric ferrocyanide, the absorbance being 0.05 to 3, when the ferric ferrocyanide is generated from potassium ferricyanide along with oxidation of acetaldehyde by the enzyme preparation.


The present invention relates to frozen liquid egg whites in which are admixed 0.01-0.4 parts of egg yolks for every 100 parts of egg whites, wherein 0.1-2 parts inclusive of -cyclodextrin are added for every 100 parts of liquid egg whites, and the turbidity H1 (degrees) calculated by means of the belowmentioned formula (1) is 18 or more: H1=H2-H3...(1). Here, H2 indicates the turbidity (degrees) of the frozen liquid egg whites measured immediately after being defrosted, and H3 indicates the egg-derived turbidity y (degrees) calculated by means of the belowmentioned approximation formula (2): y=-380.75x^(2)+272.42x+17.257...(2). Here, x indicates the admixed amount (parts) of egg yolks for every 100 parts of liquid egg whites.


The present invention relates to frozen liquid egg whites in which are admixed 0.01-0.4 parts of egg yolks for every 100 parts of egg whites, wherein 0.1-2 parts inclusive of -cyclodextrin are added for every 100 parts of liquid egg whites, and the turbidity H1 (degrees) calculated by means of the belowmentioned formula (1) is 18 or more: H1=H2H3 . . . (1). Here, H2 indicates the turbidity (degrees) of the frozen liquid egg whites measured immediately after being defrosted, and H3 indicates the egg-derived turbidity y (degrees) calculated by means of the belowmentioned approximation formula (2): y=380.75x^(2)+272.42x+17.257 . . . (2). Here, x indicates the admixed amount (parts) of egg yolks for every 100 parts of liquid egg whites.


Provided is a water-containing fluid composition comprising a processed lysozyme and/or a salt thereof, the water-containing fluid composition having a fluorescence intensity specified below of 5000 or more, wherein the processed lysozyme and/or the salt thereof is dissolved in the water-containing fluid composition while being in contact with a polar organic solvent, and a content of the polar organic solvent in the water-containing fluid composition is 55 mass% or more and 90 mass% or less. The fluorescence intensity: a fluorescence intensity measured under conditions of an excitation wavelength of 390 nm (excitation bandwidth of 10 nm) and a fluorescence wavelength of 470 nm (fluorescence bandwidth of 10 nm), for a solution obtained by adding 25 L of an 8 mM solution of 1,8-anilinonaphthalenesulfonic acid in methanol to 5 mL of a diluted solution obtained by diluting the water-containing fluid composition with a phosphate buffer solution (pH 7.0) to a concentration in terms of solid content of the processed lysozyme and/or the salt thereof of 0.05 mass% and a concentration of phosphate of 0.2 M, and thereafter allowing the solution to react at room temperature for 30 minutes.


Patent
Kewpie Corporation | Date: 2016-10-05

Disclosed is an acidic oil-in-water type emulsified condiment comprising one or more chelating agents selected from citric acid, malic acid, phosphoric acid, lactic acid, succinic acid, fumaric acid, gluconic acid, and EDTA, acetic acid, a sugar, a yolk, an edible oil, a thickener, and water, wherein the content of the edible oil is 1 to 40% by mass, and the acidic oil-in-water type emulsified condiment has a water activity of 0.90 to 0.96, a pH of 3.0 to 4.0, a viscosity (20C) of 50 to 600 Pas, and a b* value of 10 to 20 in an L*a*b* color system when preserved at 40C for 4 months.


Provided is a hyaluronic acid and/or a salt thereof having an average molecular weight of 3,500 or less, a proportion of disaccharide of 1 mass% or more and 30 mass% or less, a content of chlorine of 1 mass% or less, a content of sulfur of 1 mass% or less, and a bulk density of more than 0.25 g/cm^(3).


A method of producing a carboxymethyl-group-containing modified hyaluronic acid and/or a salt thereof includes a step of subjecting, in a water-containing solvent having a temperature of 30C or less, a dissolved raw material hyaluronic acid and/or a salt thereof to a reaction with a haloacetic acid and/or a salt thereof, the water-containing solvent including water or a liquid mixture of a water-soluble organic solvent and water, a ratio of the water-soluble organic solvent in the liquid mixture being 60 v/v% or less.


Patent
Kewpie Corporation | Date: 2016-10-05

Disclosed is an acidic oil-in-water type emulsified condiment comprising 1 to 40% by mass of an edible oil, 30 to 60% by mass of water, a thickener, a yolk, a volatile acid, and a nonvolatile acid, wherein the mass ratio between the content of the volatile acid and the content of the nonvolatile acid is 1:50 to 20:1, and the acidic oil-in-water type emulsified condiment has a dissolved oxygen concentration of 0.1 to 10% O_(2), a pH of 3.0 to 4.0, a water activity of 0.90 to 0.96, and a viscosity (20C) of 50 Pas or higher.


To provide a multidrug-resistant Gram positive bacteria antibacterial agent containing as an active ingredient a novel component to which multidrug-resistant bacteria are not resistant, and an external agent containing the same. The multidrug resistant Gram-positive bacteria antibacterial agent according to the present invention contains an amphipathic compound having an HLB value of greater than 9.5 and 20 or less and an acyl group as an active ingredient. The external agent according to the present invention contains the multidrug resistant Gram-positive bacteria antibacterial agent.

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