Kermanshah University of Medical science is a medical school in Kermanshah, Iran.Kermanshah University of Medical science is the publisher of Journal of Injury and Violence Research. Kermanshah University of Medical science is a top ranked state medical university in west of Iran. Achievements in academic excellence and innovative research, as devotion to promote overall health of the society are KUMS's main concerns.History:Kermanshah university of Medical science was first established as the Nursing College affiliated with The Ministry of Health and Welfare in 1968. After the Islamic Revolution, it was merged with college of Medicine and further developed into a medical university in 1364. In addition to medical education and treatment affairs, it has also been dealing with such areas as research, innovations, and an attempt to help develop medical and paramedical science. The university consists of six schools, seven teaching hospitals, and fourteen health centers in Kermanshah. It also has ten non teaching hospitals in the other cities of province -Islam Abad, Paveh, Salas Babajani, Javanroud, Dalahoo, Ravansar, Sarpole' Zohab, Sonqor, Sahneh, Qasre-Shirin,Kangavar, Gilan Gharb, and Harsin. The university also has 9814 employees and 236 faculty members, and based on well-defined duties and in order to serve the recent scientific and technological leap in the country it has designed scientific strategies and performed effective measures to create a healthy society in an atmosphere full of health, which are mentioned briefly.Most prominent capabilities of the university: · The presence of all branches of specialty in the university.· The presence of 24 subspecialists in different branches, and the activity of some unique subspecialties such as cardiovascular surgery, thoracic surgery, pediatric surgery, uropediatric surgery, etc. in Kermanshah.· The activities of Imam Reza Teaching and Treatment Centre as the top hospital in the West of Iran with the highest evaluation rank in the country.· The activities of the subspecial cardiovascular surgery of Imam Ali· The activities of radiotherapy, MRI, renal calculus crushing, and peripheral angiography in the public sector, being the only public center in the west of the country.· The activities of Kidney Transplant Center.· The presence of the only PND center in the west of the country to diagnose prenatal thalassemia.· Performing an educational program for dialysis ward nurses to provide coverage for the west of the country· Unique activities of dialysis ward of the teaching center if Imam Reza with 36 active beds· Proper implementation of planning the Blue Software for thalassemia patients and choosing the province as one of the ten pilot areas.· Activities of the center for minimizing the harms and quitting addiction for women and increasing their sexual health for the first time in the country.Scientific Journals of the UniversityJournal of Reports in Pharmaceutical science Frequency: Biannually Language: English Manager: Dr. Reza Khodarahmi Editor: Dr. GholamReza Bahrami Type of articles: Pharmaceutical science, Basic Medicine and Pharmacy URL: http:/ojsJRPSRESEARCH CENTERSMedical Biology Research Center URL: http:/fa/About.aspx Wikipedia.
Farzaei M.H.,Kermanshah University of Medical Sciences |
Bahramsoltani R.,Tehran University of Medical Sciences |
Rahimi R.,Tehran University of Medical Sciences
Current Pharmaceutical Design | Year: 2016
Background: Cancer is defined as the abnormal proliferations of cells which could occur in any tissue and can cause life-threatening malignancies with high financial costs for both patients and health care system. Plant-derived secondary metabolites are shown to have positive role in various diseases and conditions. The aim of the present study is to summarize clinical evidences on the benefits of phytochemicals as adjuvant therapy along with conventional anticancer therapies. Methods: Electronic databases including Pubmed, Scopus and Cochrane library were searched with the keywords “chemotherapeutic”, “anticancer”, “antineoplastic” or “radiotherapy” with “plant”, “extract”, “herb”, or “phytochemical”, until July 2015. Only clinical studies were included in this review. Results: The findings showed that positive effects of phytochemicals are due to their direct anticarcinogenic activity, induction of relief in cancer complications, as well as their protective role against side effects of conventional chemotherapeutic agents. Results obtained from current review demonstrated that numerous phytochemical agents from different chemical categories including alkaloid, benzopyran, coumarin, carotenoid, diarylheptanoid, flavonoid, indole, polysaccharide, protein, stilbene, terpene, and xanthonoid possess therapeutic effect in patients with different types of cancer. Polyphenols are the most studied components. Curcumin, ginsenosides, lycopene, homoharringtonine, aviscumine, and resveratrol are amongst the major components with remarkable volumes of clinical evidence indicating their direct anticancer activities in different types of cancer including hepatocarcinoma, prostate cancer, leukemia and lymphoma, breast and ovarian cancer, and gastrointestinal cancers. Cannabinoids, cumarin, curcumin, ginsenosides, epigallocatechin gallate, vitexin, and salidroside are phytochemicals with significant alleviative effect on synthetic chemotherapy- induced toxicities. Conclusion: There is lack of evidence from clinical trials in case of a large number of phytochemicals and further human studies are recommended to confirm the role of plant metabolites in the management of cancer. © 2016 Bentham Science Publishers.
Yari M.,Kermanshah University of Medical Sciences
Journal of injury & violence research | Year: 2013
Anterior cruciate ligament (ACL) tearing is a common injury among football players. The present study aims to determine the best single-dose of intra-articular morphine for pain relief after arthroscopic knee surgery that, in addition to adequate and long-term analgesia, leads to fewer systemic side effects. This clinical trial was conducted on 40 ASA-I athletes. After surgery, all participants received an injection of 20 cc of 0.5% intra-articular bupivacaine. In addition, the first control group received a saline injection and 5, 10 and 15 mg of morphine were respectively injected into the joints of the second, third and fourth groups by use of Arthroscopic equipment before the Arthroscopic removal. The amount of pain based on VAS at 1, 2, 4, 6 and 24 hours after surgery, duration of analgesia and the consumption of narcotic drugs were recorded. The VAS scores in the fourth, sixth and twenty-fourth hours after surgery showed a significant difference between the study groups. The average time to the first analgesic request from the bupivacaine plus 15 mg morphine group was significantly longer than other groups and total analgesic requests were significantly lower than other groups. No drowsiness complications were observed in any of the groups in the first 24 hours after injection. Application of 15 mg intra-articular morphine after Arthroscopic knee surgery increases the analgesia level as well as its duration (IRCT138902172946N3).
Yeganeh N.,Kermanshah University of Medical Sciences
Journal of injury & violence research | Year: 2013
Maintaining blood pressure (BP) and heart rate (HR) after laryngoscopy and tracheal intubation has always been a concern in injured patients. Opioids can attenuate or stop an increase in these two parameters if administered with proper doses or targets in target-controlled infusion (TCI). Remifentanil and sufentanil are widely used for this purpose because their cardiac side effects are low and, especially in traumatic patients, they are tolerated well. A comparison of the benefits and limitations of these two opioids in TCI is much needed. A literature review in electronic data bases revealed few results. 40 normotensive patients were enrolled to this randomized clinical trial study. After BIS guided anesthesia with a target-controlled propofol infusion and muscle relaxation with cisatracurium, remifentanil and sufentanil were infused using TCI with 2 and 0.2 ng.ml-1 targets respectively. BP and HR were recorded for five data points and compared with Fischer's exact test. Systolic, mean and diastolic arterial pressure and HR in different points of the study remained below baseline values but were out of control in some cases, however the out-of-control values showed significant difference between the two groups only for heart rate changes. The relative risk for producing out-of-control changes with remifentanil compared to sufentanil is significantly more than 1 for HR decrease. Sufentanil produced more common pre-intubation hypotension than remifentanil in propofol anesthetized patients but this hypotension disappeared sooner than remifentanil after tracheal intubation. Both opioids prevent an increase in BP and HR after tracheal intubation but the side effects (hypotension and bradycardia) may be a cause for concern (IRCT138710011361N3).
Ghadami M.R.,Kermanshah University of Medical Sciences
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia | Year: 2015
To compare the efficacy of gabapentin and levodopa-c (Levodopa/Carbidopa) in reducing restless leg syndrome (RLS) symptoms and sleep problems in hemodialysis patients with RLS in a four-week randomized clinical trial. The diagnosis of RLS was made using the criteria of the International Restless Legs Study Group. Each subject completed three questionnaires: IRLS questionnaire, Pittsburgh Sleep Quality Index and Epworth sleepiness scale. After four weeks of washout period for previous treatments for RLS, subjects were randomly assigned to four weeks of gabapentin (200 mg) or levodopa-c (110 mg). After four weeks of therapy, the questionnaires administered at the outset of the study were re-administered. Both drugs were found effective for the management of RLS. But, the effect of gabapentin was more significant. Gabapentin significantly improved the IRLS total score (change from baseline to post-treatment ≈-17) compared with levodopa-c (change from baseline to post-treatment ≈-13) (P: 0.016). Regarding sleep parameters, levodopa improved sleep quality, sleep latency and sleep duration (P <0.0001). Gabapentin was also effective with respect to sleep parameters (P <0.0001). Our study shows that gabapentin is a safe effective therapy for RLS among hemodialysis patients. This medication may be considered as an alternative or additive treatment to current therapeutic remedies for hemodialysis patients with RLS.
Karimi N.,Kermanshah University of Medical Sciences
Journal of injury & violence research | Year: 2014
Injury risk during childhood and adolescence vary depending on socio-economic factors. The aim of this study was to study if the risk of fatal and non-fatal unintentional injuries among foreign-born children was similar across parental educational level or not. In this retrospective cohort study we followed 907,335 children between 1961 and 2007 in Sweden. We established the cohort by linkage between Swedish national registers including cause of death register and in-patient register, through unique Personal Identification Numbers. The main exposure variable was parental (maternal and paternal) educational level. The cohorts was followed from start date of follow-up period, or date of birth whichever occurred last, until exit date from the cohort, which was date of hospitalization or death due to unintentional injury, first emigration, death due to other causes than injury or end of follow-up, whichever came first. We calculated hazard ratios (HR) with 95% confidence intervals (95% CI) by Cox proportional hazards regression models. Overall, we found 705 and 78,182 cases of death and hospitalization due to unintentional injuries, respectively. Risk of death and hospitalization due to unintentional injuries was statistically significantly 1.48 (95% CI: 1.24-1.78) and 1.10 (95% CI: 1.08-1.12) times higher among children with lowest parental educational level (9 years and shorter years of study) compared to children with highest parental educational level (+13 years of study). We found similar results when stratified our study group by sex of children, by maternal and paternal educational level separately, and injury type (traffic-related, fall, poisoning, burn and drowning). It seems injury prevention work against unintentional injuries is less effective among children with low parental education compared with those with higher parental education. We recommend designing specific preventive interventions aiming at children with low parental education. © 2014 KUMS, All rights reserved.
Mardanpour K.,Kermanshah University of Medical Sciences
Journal of injury & violence research | Year: 2013
This study was performed to evaluate functional and radiological results of pelvic ring fractures treatment by open reduction and internal fixation. Thirty eight patients with unstable pelvic fractures, treated from 2002 to 2008 were retrospectively reviewed. The mean patients' age was 37 years (range 20 to 67). Twenty six patients were men (4 patients with type B and 22 patients with type C fracture) and 12 women (7 patients with type B and 5 patients with type C fracture). The commonest cause was a road traffic accident (N=37, about 97%). Internal fixation was done by plaque with ilioinguinal and Kocher-Langenbeek approaches for anterior, posterior pelvic wall and acetabulum fracture respectively. Quality of reduction was graded according to Majeed score system. There were 11 type-C and 27 type-B pelvic fractures according to Tile's classification. Thirty six patients sustained additional injuries. The commonest additional injury was lower extremity fracture. The mean follow-up was 45.6 months (range 16 to 84 months).The functional outcome was excellent in 66%, good in 15%, fair in 11% and poor in 7% of the patients with type B pelvic fractures and functional outcome was excellent in 46%, good in 27%, fair in 27% and poor in 0% of the patients with type C pelvic fractures. There were four postoperative infections. No sexual functional problem was reported. Neurologic problem like Lateral cutaneous nerve of thigh injury recovered completely in 2 patients and partially in 2 patients. There was no significant relation between functional outcome and the site of fracture (P greater than 0.005). Unstable pelvic ring fracture injuries should be managed surgically by rigid stabilization. It must be carried out as soon as the general condition of the patient permits, and even up to two weeks.
Rahimi Z.,Kermanshah University of Medical Sciences
Journal of Nephropathology | Year: 2012
Context: Angiotensin converting enzyme (ACE) gene encodes ACE, a key component of renin angiotensin system (RAS), plays an important role in blood pressure homeostasis by generating the vasoconstrictor peptide angiotensin II. Evidence Acquisitions: Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched. Results: The presence of ACE insertion/deletion (I/D) polymorphism affects the plasma level of ACE. ACE DD genotype is associated with the highest systemic and renal ACE levels compared with the lowest ACE activity in carriers of II genotype. Conclusions: In this review focus has been performed on the study of ACE I/D polymorphism in various populations and its influence on the risk of onset and progression of diabetic nephropathy. Also, association between ACE I/D polymorphism and response to ACE inhibitor and angiotensin II receptor antagonists will be reviewed. Further, synergistic effect of this polymorphism and variants of some genes on the risk of development of diabetic nephropathy will be discussed. © 2014 by Journal of Nephropathology (JNP).
Shahlaei M.,Kermanshah University of Medical Sciences
Chemical Reviews | Year: 2013
Quantitative structure-activity relationship (QSAR), an important area of drug design and discovery, searches information relating chemical structure to biological and pharmaceutical activities. Nowadays, one cannot talk about drug design and discovery without mentioning QSAR. Descriptor selection is aimed at getting rid of those calculated descriptors that are redundant, noisy, or irrelevant for the model building tasks envisaged, in such a way that the dimensionality of input space can be reduced without loss of important information. Selecting appropriate descriptors for QSAR analyses is a difficult task to accomplish as there are no absolute rules that govern this selection. There are two broad strategies that can be employed for reduction of descriptors, wrapper methods and filter methods. In a typical QSAR, descriptors are usually selected using a heuristic to maximize some score with respect to a single classifier or regression algorithm.
Rahimi Z.,Kermanshah University of Medical Sciences
BioMed Research International | Year: 2013
There is large variation in the molecular genetics and clinical features of hemoglobinopathies in Iran. Studying structural variants of hemoglobin demonstrated that the β-chain variants of hemoglobin S and D-Punjab are more prevalent in the Fars (southwestern Iran) and Kermanshah (western Iran) provinces, respectively. Also, α-chain variants of Hb Q-Iran and Hb Setif are prevalent in western Iran. The molecular basis and clinical severity of thalassemias are extremely heterogenous among Iranians due to the presence of multiethnic groups in the country. β-Thalassemia is more prevalent in northern and southern Iran. Among 52 different β-thalassemia mutations that have been identified among Iranian populations, IVSII-1 G:A is the most frequent mutation in most parts of the country. The presence of IVS I-5 G:C mutation with high frequency in southeastern Iran might reflect gene flow from neighboring countries. A wide spectrum of α-thalassemia alleles has been detected among Iranians with - α 3.7 kb as the most prevalent α-thalassemia mutation. The prevention program of thalassemia birth in Iran has reduced the birth rate of homozygous β-thalassemia since the implementation of the program in 1997. In this review genetic epidemiology, clinical and hematological aspects of hemoglobinopathies, and the prevention programs of β-thalassemia in Iran will be discussed. © 2013 Zohreh Rahimi.
Aliabadi A.,Kermanshah University of Medical Sciences
Anti-Cancer Agents in Medicinal Chemistry | Year: 2016
In recent years, researchers like medicinal chemists in the field of medicinal chemistry have widely utilized the 1,3,4-thiadiazole nucleus to investigate its biological and pharmacological effects. This heterocyclic structure has demonstrated various bioactivities such as antifungal, antimicrobial, antiviral, antileishmanial, anti-inflammatory, antihypertensive, antiepileptic, and anticancer effects among others. Anticancer activity is one of its promising effect as five membered heterocyclic rings have widely been investigated by researchers in the recent years. Herein, we reviewed the chemical structures bearing 1,3,4-thiadiazole template exerting anticancer activity. © 2016 Bentham Science Publishers.