Aminzadeh A.,Kerman Medical University
Metabolic Brain Disease | Year: 2017
Tropisetron, a selective 5-HT3 receptor (5-HT3R) antagonist, is widely used to counteract chemotherapy-induced emesis. There is growing interest concerning the beneficial effects of tropisetron on the treatment of several diseases. This study was carried out to examine effects of tropisetron on high glucose (HG) induced apoptosis in PC12 cells as a suitable culture model for studying neuronal functions. Apoptosis was induced by HG, and cells were treated with HG in the absence and presence of tropisetron for varying periods of time. The viability of PC12 cells was measured by MTT assay. The ROS (reactive oxygen species) production, lipid peroxidation (LPO) levels and total antioxidant power (TAP) were measured. The expressions of proapoptotic Bax, antiapoptotic Bcl-2, caspase-3, total and phosphorylated JNK and P38 MAPKs were also examined by western blotting. The results indicated that pretreatment with tropisetron significantly improved the viability of the cells and protected PC12 cells against HG induced apoptotic cell death. It could increase the concentrations of TAP. HG induced ROS generation, Bax expression and caspase 3 activation, were prevented by tropisetron. HG also induced activation of JNK and P38 MAPKs. The phosphorylation of these kinases was inhibited by tropisetron. It may be concluded that tropisetron treatment protects PC12 cells against HG-induced apoptosis by preventing JNK, P38 activation and mitochondrial pathway. © 2017 Springer Science+Business Media New York
Mansouri S.,Kerman Medical University
Roumanian archives of microbiology and immunology | Year: 2012
Klebsiella pneumoniae is a major cause of nosocomial infections. Emergence of antibacterial resistance and production of beta-lactamases are responsible for the frequently observed empirical therapy failures. The aim of this study was to determine the presence and the prevalence of extended spectrum beta-lactamases (ESBLs) and AmpC beta-lactamases in clinical isolates of K. pneumoniae in Kerman, Iran. Resistance to different antibiotics was determined using standard disk diffusion method. The beta-lactamases phenotypes were determined by combined disk method. Polymerase chain reaction (PCR) was used to determine blaCTX-M and blaCMY genes in the ESBLs and AmpC positive isolates. Out of the 75 K. pneumoniae isolates, 31 (41.3%) produced ESBLs, 11 (14.6%) produced AmpC beta-lactamases and 1 (1.3%) was resistant to imipenem, probably by the production of a metallo beta lactamase in the phenotypic assay. Simultaneous production of ESBLs and AmpC beta-lactamases as well as the concomitant presence of blaCTX-M and blacMY genes was detected in one isolate. Prevalence of blaCTX-M and blaCMY among isolates were 20% and 2.6%, respectively. Beta-lactam therapy can fail when beta-lactamase-hyper-producing organisms appear in an infection. The occurrence of isolates co-expressing many types of beta-lactamases can cause serious problems, regarding the treatment of infections caused by these pathogens.
Shahidi Bonjar L.,Kerman Medical University
Medical Hypotheses | Year: 2013
This hypothesis would help to elevate safety in nanogold-therapy of some cancers. It has no previous record in published media and there is no existing protocol for what is expressed in this paper. The hypothesis makes some experimental recommendations for future research at the interface of nanotechnology and biological systems. It is about reducing toxicity and side effects of nanogold particles (NGPs) in cancer patients treated with antibody-nanogold therapeutics. The hypothesis expresses that how to eliminate idle NGPs from blood stream of treated cancer patients in order to reduce undesirable deposition and accumulation of NGPs in non-target tissues and organs in post therapy. In this regard, at the end of therapy period, blood of treated cancer patient which contains idle nanogold-antibodies is passed through a machine named " Nanogold detoxifying machine" (NDM). This machine behaves like " hemodialysis machine" used for patients with lost kidney function but, instead of dialysis membrane, NDM is equipped with impermeable membrane containing nanotubes to which cancer specific-antigens (CSAs) are attached. While blood circulates in NDM, CSAs attract and immobilize the idle nanogold-antibodies. Implementation of NDM clears patient's blood from idle nanogold-antibodies which were not attached to their targets, the cancer cells. Elimination of idle NGPs from blood would minimize side effects resulting from their deposition or accumulation on non-target cells or tissues. Since NDM reduces anxieties about side effects, it would provide patients with better feelings too. NDM would enhance efficacy of NGPs targeted toward specific cancers. Before using it for clinical trials in human cases, NDM should pass animal evaluations; however, research works should optimize its implementation. I think NDM method holds great promise to reduce the time, effort, and expense in cancer research, screening, detection, and therapy. © 2013 Elsevier Ltd.
Mazhari S.,Kerman Medical University
Journal of Psychiatric Practice | Year: 2013
An examination of top-cited articles is a tool that can be used to identify and monitor outstanding scientific research. The goal of this study was to identify and analyze the characteristics of the 100 top-cited articles published in international journals dedicated to psychiatry. The Science Citation Index Expanded provided by the Thomson Reuters Institute for Scientific Information Web of Knowledge was searched in December, 2011, and 128 journals were identified in the subject category "Psychiatry." Each journal was searched on the Web of Science under "Publication Name" and the results were sorted by category "Times Cited." The 100 top-cited articles were recorded, and the list was analyzed with regard to journals, number of citations, authors, year, institution, and country of origin. The original research articles of the 100 top-cited articles were classified into one of five categories: scale/measurement, descriptive/epidemiology, mechanism, management, and imaging. The 100 top-cited articles were cited between 26,578 and 781 times; they were published between 1957 and 2005, with the largest number (35) published in the 1990s. The articles appeared in 24 journals, with more than half published in the Archives of General Psychiatry (56), followed by the American Journal of Psychiatry (6), and Psychological Medicine (6). Articles that dealt with the development, application, or validity of measurements led the list of top-cited psychiatric publications (43) and had a significantly higher number of citations compared with the rest of the articles. The time and language of publication, field of study, country of origin, and journal in which the paper appeared are possible determinants of the likelihood of citation and impact. Copyright © 2013 Lippincott Williams & Wilkins Inc.
Moghaddam H.M.,Kerman Medical University
International Journal of Electrochemical Science | Year: 2011
A carbon nanotube (CNT) paste electrode was constructed for the determination of carbidopa (CD). Owing to the unique structure and extraordinary properties of CNTs, the modified electrode has shown an obvious electrocatalytic activity towards oxidation of CD, which leads to lowering its overpotential by more than 400 mV. Also, the values of electron transfer (α=0.34). and diffusion coefficient (D 0=5.9×10 -6 cm 2/s) for CD were calculated. Under the optimum conditions, the oxidation peak currents were linearly proportional to the concentration of CD in the range from 0.07-600.0 μM. The detection limit was 29.0 nM. Then the modified electrode was used to determine CD in an excess of acetaminophen (AC). Finally, the proposed sensitive and simple electrochemical method was successfully applied to CD and AC determination in urine samples. © 2011 by ESG.
Moosazadeh M.,Kerman Medical University
International Journal of Preventive Medicine | Year: 2013
Background: Cigarette Smoking is a recognized cause of systemic disorders such as bronchogenic, carcinoma, and cardiovascular diseases and hence prompt and effective interventions are required for its elimination. Thus, This Meta-analysis was carried out for an adult population of west of Iran in order to estimate of prevalence smoking in this area. Methods: We examined related to documentation by searching in published and non-electronic databases. Data were extracted based on variables such as the year of the study, sex, age group, and the prevalence of smoking. Based on the results of heterogeneity, we used fixed or random effects model to assessment the overall prevalence of cigarette smoking. All analyses were accomplished via STATA 11 software. Results: Totally, 25, 990 subjects (13005 males) were investigated. Meta-analysis in men and women indicated prevalence of 22.9 (20.6-25.2) and 0.6 (0.3-0.9) respectively. Conclusions: It was found that more than one-fifth of men from 15 year to 64-year-old of west of Iran smoked cigarette. Providing an education on harmful effects of smoking to the adult population would be a valuable means for reducing destructive consequences of smoking.
Mazhari S.,Kerman Medical University
Psychiatry and clinical neurosciences | Year: 2014
The Brief Assessment of Cognition in Schizophrenia (BACS) is designed for assessment of cognitive function in patients with schizophrenia. Versions of the BACS in English and other languages have been shown to be as sensitive to cognitive dysfunction as a standard test battery, with the advantage of brief administration and scoring time. The present study aimed to test the concurrent validity of the Persian version of the BACS (Persian-BACS). A group of 50 patients with schizophrenia-spectrum disorders and a group of 50 healthy controls received the Persian-BACS in a first session, and in a second session a standard neurocognitive battery. Cronbach's alpha for the Persian-BACS was 0.74. All the Persian-BACS subscales were significantly correlated with the corresponding standard neurocognitive subscales and the Pearson correlation of the composite scores from the two instruments was 0.71. Moreover, a one-factor solution was found that accounted for 67.9% of the variance. Finally, the Persian-BACS demonstrated high ability to discriminate patients with schizophrenia from healthy controls. Good psychometric properties of the Persian-BACS suggest that it is a useful tool for assessing cognition in schizophrenic patients with Persian as their primary language. © 2013 The Authors. Psychiatry and Clinical Neurosciences © 2013 Japanese Society of Psychiatry and Neurology.
Mazhari S.,Kerman Medical University
Cyberpsychology, Behavior, and Social Networking | Year: 2012
Previous studies have examined the relationship between problematic Internet use (PIU) with pathological gambling and impulsivity. However, few studies have investigated the association between PIU and other impulse control disorders. This study aimed to assess whether PIU is related to compulsive buying, kleptomania, trichotillomania, intermittent explosive disorder, and pyromania, among a sample of Iranian university students. A cross-sectional study design was used among a random sample of (n=950) university students. Self-reported questionnaires, including demographic, Problematic Internet Use Questionnaire (PIUQ) and Minnesota Impulse Disorders Interview were utilized. The prevalence of PIU was 21.2 percent. Students with diagnosis of either compulsive buying, or intermittent explosive disorder, or pyromania had significantly higher scores on PIUQ compared to the students without the diagnosis. Multivariate regression analyses indicated that in the male gender, the diagnosis of either compulsive buying or intermittent explosive disorder were significant predictors of the risk of the PIU. The results support the proposal that PIU should be considered as a spectrum of impulse control disorder. © 2012, Mary Ann Liebert, Inc.
Rastegari A.,Kerman Medical University
Global journal of health science | Year: 2013
The size of active network (C) of Iranian population is a very important parameter to estimate the size of unknown population using Network Scale Up (NSU) technique. However, there is little information about this parameter not only in Iran but also in other countries in Middle East region. Based on these needs, the aim of this paper is to estimate C for the Iranian population. Based on available national statistics, 23 reference groups, with known population sizes were selected. Using multistage sampling method, 7454 individuals were recruited randomly around the country. We asked from our samples how many people they knew from each of the reference groups. Using NSU formulae, we maximized the goodness of fit of our estimation about the size of the reference groups by fitting the best C. However, the final C was set by excluding some of the reference groups with no added information; these inappropriate groups were selected by two techniques; regression, and ratio based approaches. Applying regression and ratio based approaches the estimated C was 308 and 380 respectively. The Pearson correlation coefficient between the real and estimated size of reference groups (based on our C) in both methods was above 0.95. However, results of ratio based had better performance. We saw that the network of males, singles, younger age groups, and those with higher education was larger than those in other groups. It seems that C in Iran is higher than that in developed countries, possibly because of its social structure. Because of cultural and social similarities in Middle East courtiers, C in other countries also might be higher than that in developed countries.
Garrusi B.,Kerman Medical University
Global journal of health science | Year: 2013
Many socio cultural variables could be affect eating disorders in Asian countries. In Iran, there are few researches regarding eating disorders and their contributing factors. The aim of this study is to explore frequency of eating disorders and their risk factors in an Iranian population. About 1204 participants were selected aged between fourteen to 55 years. Frequency of eating disorders and effects of variables such as demographic characteristics, Body Mass Index (BMI), use of media, body dissatisfaction, self-esteem, social comparison and social pressure for thinness in individuals with and without eating disorders, were assessed. The prevalence of eating disorders was 11.5% that included 0.8% anorexia nervosa, 6.2% full threshold bulimia nervosa, 1.4% sub threshold anorexia nervosa and 30% sub threshold binge eating disorder. Symptoms of bulimic syndrome were greater in males. In Iran, eating disorders and related problems are new issue that could be mentioned seriously The identification of these disorders and their related contributing factors are necessity of management and preventive programs planning.