Kerala University of Health Sciences
Trichur, India

Kerala University of Health science is a medical university in the city of Thrissur in Kerala, India. The university is located in 75 acres on the Government Medical College, Thrissur campus. The university was established on the basis of Kerala University Health Act 2010. There are 205 professional colleges affiliated to this university. Wikipedia.

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Ziaudeen S.,Kerala University of Health Sciences | Ravindran R.,Kerala University of Health Sciences
Journal of Clinical and Diagnostic Research | Year: 2017

Introduction: Despite its vast occurrence, the aetiology of Recurrent Aphthous Stomatitis (RAS) still remains unknown and its aetiology is multifactorial. The factors believed to be associated with the aetiology of RAS, may disturb the equilibrium of oxidant-antioxidant status of the organism and may accelerate the formation of free radicals, resulting in Oxidative Stress (OS). Psychological stress is believed to act as a triggering factor or modifying factor for RAS. Aim: To find whether oxidant-antioxidant status and psychosocial stress play a role in the pathogenesis of RAS. Materials and Methods: The study was conducted on 60 subjects over a period of one year (August 2014-August 2015) equally divided into two groups-patients with RAS and healthy controls. Psychosocial stress was analyzed by using Recent Life Changes Questionnaire (RLCQ). Saliva was analyzed to evaluate Superoxide Dismutase (SOD) and Glutathione Peroxidase (GSHPx) activities, Malondialdehyde (MDA) and Uric Acid (UA) levels in both the study and the control groups, using UV spectrophotometry. Results: The mean value of salivary SOD and MDA was increased while the activity of GSHPx and UA decreased in the study group when compared to the controls; the difference being statistically significant (p<0.005). The mean RLCQ stress score was also found to be increased in the RAS group, which showed elevated levels of mental stresses when compared to physical stresses. No significant association was observed between SOD, MDA, GSHPx and UA with high levels of stress score (p>0.05). In the study group, no correlation was observed between the study variables and gender, the number of ulcer episodes in one year, the number of ulcers per episode or the duration of ulcers. Conclusion: This study shows that salivary antioxidant levels show a significant difference in response to OS in RAS patients. An increase in levels of psychosocial stress is seen associated with patients with RAS indicating its role as a modifying or triggering factor in the initiation of RAS. © 2017, Journal of Clinical and Diagnostic Research. All rights reserved.

Gujaral P.B.,Kerala University of Health Sciences | Ajay B.,Amrita University
Journal of Forensic Sciences | Year: 2017

Abrasion collar is usually described as a feature of bullet entry wounds caused by friction and indentation. The present case is that of the peculiar entry wound caused by a piece of flying shrapnel which was ejected from a furnace in a steel plant. The scrap metal which exploded in the plant was sourced from the West Asia region. The entry wound on the chest was circular and had an abrasion collar around it. The projectile was a cylindrical object of obscure origin. The forensic science laboratory put forth the possibility that the projectile was a component of an artillery fuze. A decades old study which employed high-speed photography has rejected the possibility that abrasion collars are produced by friction. High-velocity projectiles other than bullets can also produce abrasion collars as the rubbing of the bullet against the skin or its rotation are not the causative mechanisms. © 2017 American Academy of Forensic Sciences.

Nair M.K.C.,Medical College | Nair M.K.C.,Kerala University of Health Sciences
Indian Journal of Practical Pediatrics | Year: 2015

Behavioural, emotional and mental health problems are widely prevalence among adolescents in India. Primary care physicians or pediatricians need to recognize and manage a majority of anxiety and depression problems among adolescents due to limited availability of psychiatrists or clinical psychologists. Anxiety disorders may be generalized anxiety disorders, phobias, panic disorders, obsessive compulsive disorders, post traumatic stress disorders, etc. Depression in adolescent may be difficult to identify due to the normal behavioural variations associated with hormonal changes in this age group. It can manifest as low self-esteem, difficulty in establishing autonomy and suicidal ideation. Depression may be mistaken for attention deficit hyperactivity disorder or may present with physical ailments. In the majority of children with depression, both psychotherapy and medication are required.

Satheeshkumar P.S.,University of Cardiff | Satheeshkumar P.S.,Kerala University of Health Sciences | Mohan M.P.,Kerala University of Health Sciences
Digestive Diseases and Sciences | Year: 2014

The alimentary tract mucosal inflammation has been a topic of concern in oncology; though many modalities of treatment have been proposed for mucosal inflammation, the contributing adverse effects have severely affected the quality of life of patients. This review focuses on the importance of neurogenic peptide, Substance P and its receptor NK-1R in modulating the cascades of events in mucosal inflammation during cytotoxic therapy. There are various preclinical and clinical models showing increased expression of Substance P/NK-1R in ionizing radiation and chemotherapy, but only very few preclinical studies to our knowledge have highlighted or examined its role in mucosal inflammation. Hence, the importance of neuropeptide involved in the inflammatory events in mucosal inflammation in cytotoxic therapy could be a major breakthrough for future research purposes and treatment. The factors contributing to the severity of tissue reactions have been multietiogenic; thus, resultant treatment also has to be directed toward multiple contributing factors. This review also focuses on the significance of care strategy to be adopted in alimentary tract mucositis when multietiogenic factors are taken into consideration. © 2014, Springer Science+Business Media New York.

Motagi M.V.,Kerala University of Health Sciences | Ranganath V.,Newcastle University Medicine Malaysia
Journal of Clinical and Diagnostic Research | Year: 2013

Aim: The classic variants in superior articular facets of atlas such as, variability in shape, presence of notch, constrictions, partial or complete separation of facets, and presence of pressure facets, have been reported to a limited extent in relation to ergonomics of cranio-vertebral joint. Objective: The objectives of the present study were to report the analyzed morphological features and metrical values of superior articular facets of the atlas. The morphological features which were included in this study were variability in shapes, constrictions and partial or complete separation of facets. The metrical measure included the surface area measurement of the facets. Material and Methods: This study was carried out on 50 (100 sides) dry atlas vertebrae from the Department of Anatomy, St John's Medical College, Bangalore, India. The superior articular facets were studied for the shape and symmetry, constrictions and partial or complete separation of facets. The surface area of the facets were measured by using IMAGEJ (Image processing and analysis in JAVA) tool, that was primarily designed to measure and analyze different metrics. Results: The mean surface area on the right side was 157.3 ± 29.02, and on the left side, it was 158.5 ± 24.85. Oval, irregular, kidney and figure of eight shapes were observed either on both sides or on one side. Bilateral constrictions of facets were seen in 58% of vertebrae. Bilateral, complete separations of facets were seen in 30% of vertebrae Conclusion: The observations of the present study are important to understand the ergonomics of the cranio-vertebral joint and they are helpful for academicians, neuro-surgeons, clinicians and radiologists in day to day clinical practice.

Mohamed H.,Kerala University of Health Sciences
World Journal of Laparoscopic Surgery | Year: 2012

Background: Sleeve gastrectomy is becoming increasingly popular within bariatric surgery. Initially introduced as a component of complex interventions and later as part of a two-stage operation in high-risk patients, the procedure is now more common as one-stage operation and subject of avid scientific discussion. However, the concept of longitudinal gastric resection is not new. The procedure was already established in ulcer surgery but soon faded into insignificance. This article aims to trace the historical development of resection of the greater curvature and review the current value of sleeve gastrectomy within the spectrum of bariatric surgical procedures. Materials and methods: Extensive review of literature of articles published in english language was conducted using the following search engines: Google, Yahoo, Medline, PubMed, Medscape, HighWire press and the SpringerLink library available at the World Laparoscopy Hospital, Gurgaon, India. Articles that matched the criteria were selected for review. Results: Six reviews and 90 articles were selected and reviewed and analyzed to reach the conclusions. Conclusion: Laparoscopic sleeve gastrectomy is a safe and effective weight loss procedure. Resolution of comorbidity, health-related quality of life and food tolerance were comparable with that of Roux-en-Y gastric bypass with lower incidence of complications comparable to gastric banding. However, there is need for standardization of the procedure and long-term results are yet to be analyzed.

PubMed | Kerala University of Health Sciences
Type: Case Reports | Journal: Journal of cancer research and therapeutics | Year: 2016

Myoepithelioma, once considered to be a type of pleomorphic adenoma, is a rare benign tumor of the salivary glands. This uncommon tumor is most commonly diagnosed in the parotid gland and in the minor salivary glands of the palate. We report a case of myoepithelioma located at the base of tongue, a rare site, in a 48-year-old male, composed of spindle shaped myoepithelial cells.

PubMed | Kerala University of Health Sciences
Type: Journal Article | Journal: Iranian journal of cancer prevention | Year: 2016

Kerala is a highly urbanized state in India and interstate migrant laborers working there forms a marginalized community. It was generally perceived that use of tobacco and alcohol was high among the workers, but there are no epidemiological studies assessing the actual burden.To estimate the prevalence of use of tobacco and also the prevalence of oral mucosal lesions associated with such use consumption among the adult male interstate migrant workers in North Kerala.A cross sectional study was carried out among male migrant workers above 18 years working in different factories in urban parts of Kannur district. Total of 244 participants attending routine health check-up camp were assessed for the use of tobacco/alcohol, type, frequency and duration of their use by a questionnaire. The trained dental interns conducted oral cavity examination for detecting oral mucosal lesions associated with tobacco use.The prevalence of current use of smoked tobacco, smokeless tobacco and alcohol use were 41.8%, 71.7% and 56.6%, respectively among migrants. Oral mucosal lesions (OML) were seen in 36.3% of participants. Among smokeless tobacco users, 44.6% had lesions. Adjusted odds ratio for OML was 4.5 (CI: 1.9 - 19.84) among smokeless tobacco users.The current use of smokeless tobacco and oral mucosal lesions are highly prevalent among migrant workers.

PubMed | Child Development Center, Government TD Medical College and Kerala University of Health Sciences
Type: Journal Article | Journal: Indian journal of pediatrics | Year: 2016

This article is our life time experience in conceptualizing and systematically developing Child Development Centre (CDC) Kerala in the last 25 years, from a research project to a national training centre in child and adolescent development and premarital counseling. CDC Keralas major contribution was in creating a conceptual framework of a valid link between childhood disability, low birth weight, adolescent girls nutrition and fetal onset adult lifestyle diseases. It all started with a randomized controlled trial (RCT) proving beyond doubt that early stimulation is effective in improving the neurodevelopmental status of high risk babies at one and two years and the same cohort was followed-up in detail at 5, 13, 16, 19 and 24 completed years. The process of establishing CDC Kerala is being presented under (i) clinical child development, (ii) adolescent care counseling, (iii) young adults and premarital counseling and (iv) institution building.

PubMed | Kerala University of Health Sciences
Type: Journal Article | Journal: Indian pediatrics | Year: 2016

Health care counseling (HCC) is a relatively new concept that amalgamates human biology, human psychology and medical sociology principles, and applies the same in real-time clinical situations. In India, there is a real paucity of trained mental health personnel, and hence counseling services are restricted to few departments. HCC is especially important for the child population, as the pediatricians need to partner the parenting responsibilities in different illness care settings covering the period from newborn to adolescence. This paper proposes steps for further development of the concept, expertise and systematic training program for health personnel, as an activity of Centre for Health Care Counseling Studies under Kerala University of Health Sciences. Once the process is documented, we hope that the same would be made available to other states in India.

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