Kerala Agricultural University is the primary and the principal instrumentality of the Kerala state in providing human resources, and skills and technology, required for the sustainable development of its agriculture, defined broadly encompassing all production activities based on land and water, including crop production , forestry and fisheries through conducting, interfacing and integrating education, research and extension in these spheres of economic endeavour. It is situated in Vellanikkara, Thrissur, Kerala.Dr. P. Rajendran is the Vice-Chancellor and Dr. E.K. Mathew is the Registrar Wikipedia.
Roy N.,Kerala Agricultural University
Asian Pacific journal of cancer prevention : APJCP | Year: 2016
BACKGROUND: Colorectal cancer (CRC) or bowel cancer is one of the most important cancer diseases, needing serious attention. The cell surface receptor gene human epidermal growth factor receptor (EGFR) may have an important role in provoking CRC. In this pharmaceutical era, it is always attempted to identify plant-based drugs for cancer, which will have less side effects for human body, unlike the chemically synthesized marketed drugs having serious side effects. So, in this study the authors tried to assess the activity of two important plant compounds, ferulic acid (FA) and p-coumaric acid (pCA), on CRC.MATERIALS AND METHODS: FA and pCA were tested for their cytotoxic effects on the human CRC cell line HCT 15 and also checked for the level of gene expression of EGFR by real time PCR analysis. Positive results were confirmed by in silico molecular docking studies using Discovery Studio (DS) 4.0. The drug parallel features of the same compounds were also assessed in silico.RESULTS: Cytotoxicity experiments revealed that both the compounds were efficient in killing CRC cells on a controlled concentration basis. In addition, EGFR expression was down-regulated in the presence of the compounds. Docking studies unveiled that both the compounds were able to inhibit EGFR at its active site. Pharmacokinetic analysis of these compounds opened up their drug like behaviour.CONCLUSIONS: The findings of this study emphasize the importance of plant compounds for targeting diseases like CRC.
Manalil S.,University of Western Australia |
Manalil S.,Kerala Agricultural University |
Busi R.,University of Western Australia |
Renton M.,University of Western Australia |
Powles S.B.,University of Western Australia
Weed Science | Year: 2011
Herbicide rate cutting is an example of poor use of agrochemicals that can have potential adverse implications due to rapid herbicide resistance evolution. Recent laboratory-level studies have revealed that herbicides at lower-than-recommended rates can result in rapid herbicide resistance evolution in rigid ryegrass populations. However, crop-field-level studies have until now been lacking. In this study, we examined the impact of low rates of diclofop on the evolution of herbicide resistance in a herbicide-susceptible rigid ryegrass population grown either in a field wheat crop or in potted plants maintained in the field. Subsequent dose-response profiles indicated rapid evolution of diclofop resistance in the selected rigid ryegrass lines from both the crop-field and field pot studies. In addition, there was moderate level of resistance in the selected lines against other tested herbicides to which the population has never been exposed. This resistance evolution was possible because low rates of diclofop allowed substantial rigid ryegrass survivors due to the potential in this cross-pollinated species to accumulate all minor herbicide resistance traits present in the population. The practical lesson from this research is that herbicides should be used at the recommended rates that ensure high weed mortality to minimize the likelihood of minor herbicide resistance traits leading to rapid herbicide resistance evolution. © 2011 Weed Science Society of America.
Satheesan J.,Rajiv Gandhi Center for Biotechnology |
Narayanan A.K.,Kerala Agricultural University |
Sakunthala M.,Rajiv Gandhi Center for Biotechnology
Mycorrhiza | Year: 2012
Centella asiatica (Indian pennywort) has wide application in Indian and Chinese traditional medicines with documented evidence for wound healing and neuroprotective and anti-aging potential. Asiaticoside, a trisaccharide triterpene, is the most medicinally active compound in the plant. β-Amyrin synthase and squalene synthase have been identified as the two key genes in the triterpenoid pathway which regulate the production of asiaticoside in C. asiatica. The paper reports salient findings of our study utilizing the growth-promoting endophytic fungus Piriformospora indica to successfully colonize roots of C. asiatica in vitro cultures for investigating the effect of the mutualistic association on asiaticoside production. Co-cultivation of P. indica resulted in the rapid enhancement of root and shoot biomass of host plant, which was visible after 7 days of culture and continued up to 45 days. P. indica co-cultivation also favored the synthesis of asiaticosides, as evidenced by HPLC analysis which indicated about twofold increase (0.53% (w/w) in leaves and 0.23% (w/w) in whole plant) over control (0.33% (w/w) in leaves and 0.14% (w/w) in whole plant). Real-time PCR results confirmed the strong upregulation of squalene synthase and β-amyrin synthase transcripts in P. indica-challenged plants compared with the control. Our data demonstrate the potential use of P. indica as a means to enhance plant secondary metabolite production in planta with scope for further field evaluation. © 2011 Springer-Verlag.
Panjikkaran S.T.,Kerala Agricultural University
Indian Pediatrics | Year: 2013
The prevalence of overweight/obesity among 6000 children at 7-12 years was monitored using the established methodologies. Prevalence rates obtained using percentiles were proximate to that using waist-to-height ratio (WHTR) 0.50 and were on par with the reported rates. The prevalence were worked out with WHTR values from 0.45 to 0.53 and compared with percentiles. The minimum per cent deviation of 5.4 was observed at WHTR of 0.48 (against 6.4% at WHTR 0.50) and further the deviation at this point was distributed near-uniformly (2.6% above and 2.8% below the WHTR), suggesting that this is the optimum cutoff point for children in this region. ROC analysis against percentiles has given a higher sensitivity of 0.630 at WHTR 0.48 in this region and area under ROC curve was 0.827 at WHTR 0.48. © 2013 Indian Academy of Pediatrics.
Paul J.,Kerala Agricultural University
Advances in Intelligent Systems and Computing | Year: 2014
Health informatics is an emerging field of the day. It is the appropriate and innovative application of the concepts and technologies of the information age to improve health care and health . Right from consultation, through prescription till the completion of treatment and medication can be implemented online. A network that includes the hospitals, clinics, pharmacies, diagnostic centers and insurance companies sharing the pooled resources can perform in co-ordination and work for the common goal of delivering medical claims to the stakeholders. An online software that works on Windows Server platform with SQL Server as backend and the ASP.NET programs do the purpose. © Springer International Publishing Switzerland 2014.
Mohan Kumar B.,Kerala Agricultural University
Journal of Tropical Agriculture | Year: 2011
Kerala with many woody perennial-based land use practices is one of the "Meccas" of agroforestry. Twenty-five years of research has demonstrated the potential of agroforestry as a sustainable production system in the state. Aspects such as system inventory and dynamics, species richness, belowground interactions, nutrient cycling, tree and stand management, carbon sequestration potential, timber and fuelwood properties, and socioeconomic aspects were the major themes investigated. Considering the state's unique land use, demographic, political, and sociocultural characteristics, Kerala's experience in agroforestry research is important to agroforestry development, especially in the humid tropical regions. Although agroforestry has received much attention from researchers, for its perceived ability to contribute to environmental quality, agrobiodiversity conservation, and nutrient cycling, the policy makers are yet to fully recognize such benefits and agroforestry extension is either weak or non-existent in the state. This calls for more process-oriented research and policy initiatives to promote agroforestry among the farmers of Kerala.
Jayachandran K.V.,Kerala Agricultural University
Indian Journal of Animal Sciences | Year: 2010
Prawns and shrimps comprise about 2500 species and are distributed throughout the world. They belong to complex taxonomic groups. The prawns of the family Palaemonidae Rafinesque, 1815 are highly important on both commercial as well as ecological point of view. Extensive studies on the biodiversity and taxonomy of Indian freshwater prawns have been carried out by many and they have recorded 75 species belonging to 8 genera under the subfamily Palaemoninae Rafinesque, 1815 and these prawns inhabit a wide range of habitats from hill top to estuaries. The present paper provides a comprehensive account on various aspects such as diversity of species, state wise distribution of species, taxonomie status and confusion, molecular taxonomy, karyological information, distribution based on their habitat, present level of utilization of diversity, research challenges and also ex situ and in situ conservation methods and needs of palaemonid prawns of India.
Kumar B.M.,Kerala Agricultural University
Agriculture, Ecosystems and Environment | Year: 2011
Tropical homegardens with high agrobiodiversity have high potential for carbon (C) sequestration, especially under changing environments. Floristic diversity, richness, and aboveground C stocks and how size of homegardens influence agrobiodiversity and C sequestration potential were assessed in the Kerala homegardens. A total of 839 homegardens in 28 panchayaths (lowest unit of local self-government) of Thrissur, Palakkad, and Malappuram districts were surveyed through a stratified random process. Information was gathered on holding size, floristic composition, plant height, and girth at breast height (GBH) of all trees and shrubs (>20cm GBH). Aboveground C stocks of trees were computed using allometric relationships, assuming C as 50% of biomass. The homegardens were also classified into small (<0.4ha), medium (0.4-1.2ha), and large (>1.2ha). In total, 473 species were recorded, of which 208 were trees (>20cm GBH), 86 shrubs, and 179 herbs. Simpson's floristic diversity index (0.64, 0.41, and 0.46 for a subset of small, medium, and large homegardens, respectively), species richness, and tree density (per hectare) were highest for small-sized holdings. Large-sized homegardens, however, had more stems per garden. Average aboveground standing stocks of C ranged from 16 to 36Mgha -1, with small homegardens having higher C stocks on unit area basis than large- and medium-sized ones. Implicit in this is the potential for C sequestration and agrobiodiversity conservation, especially by small homegardens. © 2011 Elsevier B.V.
Prathapan K.D.,Kerala Agricultural University
ZooKeys | Year: 2016
Madurasia Jacoby is revised and M. andamanica sp. n., endemic to the Andaman Islands in the Indian Ocean, is described and illustrated. Madurasia obscurella Jacoby, syn. n., is a new junior synonym of Madurasia undulatovittata (Motschulsky), comb. n. A lectotype is designated for M. obscurella. Literature on the biology and management of M. undulatovittata is reviewed. © Kaniyarikkal Divakaran Prathapan.
Kumar V.,Kerala Agricultural University
Nature Environment and Pollution Technology | Year: 2016
Agroforestry is emerging as a major land use activity in the country after agriculture and forestry. Traditional resource management adaptations such as agroforestry systems may potentially provide options for improvement in livelihoods through simultaneous production of food, fodder and firewood as well as mitigation of the impact of climate change. The multifunctional agroforestry systems in tropical region offer innumerable ecological benefits such as carbon sequestration, mitigation of climate change, enhancing soil fertility and water use efficiency, biodiversity conservation, biological pest control, sustainable land use, shelterbelt and windbreaks, microclimate amelioration, breaking the poverty and food insecurity circle, caveats and clarifications. Agroforestry, if established on degraded lands will not only reduce the anthropogenic pressure on existing forest resources but also will enhance the sink potential of CO2.