Kempegowda Institute of Medical SciencesKarnataka

India

Kempegowda Institute of Medical SciencesKarnataka

India
SEARCH FILTERS
Time filter
Source Type

Srinivasa S.,Kempegowda Institute of Medical SciencesKarnataka | Manasa G.,Kempegowda Institute of Medical SciencesKarnataka | Madhu G.N.,Kempegowda Institute of Medical SciencesKarnataka
Current Pediatric Research | Year: 2017

Introduction: Neonatal period is the most vulnerable period of life. Neonatal deaths account for 45% of all deaths among Under-five children. The main causes of neonatal deaths are prematurity and low birth weight (LBW). This study was done to assess newborn foot length and determine its utility in identifying LBW/Preterm Babies. Material and methods: This is a cross sectional study of 500 newborn babies, done in KIMS Hospital and Research Center, Bengaluru. All live newborn infants were included in the study, while babies with lower limb congenital anomalies were excluded from the study. Results: Among 500 newborns, 55.4% (n=277) were male and 44.6 % (n=223) were females. The Mean ± SD at birth for birth weight(BW), Gestational age(GA) head circumference(HC), chest Circumference (CC), length and Foot Length (FL) were 2.74 ± 0.47 kg, 37.95 ± 2.3 weeks, 33.51 ± 1.73 cm, 31.04 ± 1.73 cm, 47.84 ± 2.58 cm and 7.58 ± 0.44 cm, respectively. Males had slightly higher anthropometric values compared to females which were not statistically significant. We observed a significant correlation between FL and other anthropometric variables namely BW, GA, HC, CC and length with R value of 0.9, 0.87, 0.86, 0.81 and 0.84, respectively and a significant P value of <0.0001. For BW and GA, FL had higher correlation with R value of 0.9 and 0.87, respectively while HC, CC and length had lower values. Using Receiver Operative Characteristic (ROC) curve analysis we found that FL ≤ 7.4cm had 97.03% sensitivity and 87.05% specificity in identifying LBW babies. FL ≤ 7.4 cm had 98.81% sensitivity and 79.09% specificity for identifying preterm babies. Conclusion: We observed a significant correlation between foot length and other variables namely birth weight, gestational age, head circumference, chest circumference and length. Foot length had a higher sensitivity and specificity in identifying LBW and Preterm babies, making it a reliable variable in rural setup where weighing facilities, ultrasound and trained personnel are not available. © 2017, Scientific Publishers of India. All rights reserved.


Rajagopal I.,Kempegowda Institute of Medical SciencesKarnataka | Niveditha S.R.,Kempegowda Institute of Medical SciencesKarnataka | Sahadev R.,Kempegowda Institute of Medical SciencesKarnataka | Preethan K.N.,Kempegowda Institute of Medical SciencesKarnataka | Rajendra S.G.,Kempegowda Institute of Medical SciencesKarnataka
Journal of Clinical and Diagnostic Research | Year: 2015

Introduction: Gastric cancer is one of the leading causes of cancer mortality in the world/India with majority being diagnosed at an advanced stage. Various chemotherapeutic regimens have modestly improved overall survival leading to quest for novel therapeutic agents. Overexpression of HER2 in many gastric cancers has lead to the advent of targeted therapy with anti HER2 antibody like Trastusumab which has improved the overall survival. Materials and Methods: Sixty cases of gastric adenocarcinomas (44 biopsies and 16 gastrectomies) over the past five years (June 2009 to June 2014),were included in the study. Diagnosis was confirmed by review of slides and IHC with anti HER2 antibodies was performed using Dako Real Envision Detection system and scoring was done by Hoffmann et al., scoring system. Results: Of the 60 cases, majority were males (60%),with a mean age of 65.65 yrs. Tumours in antrum (76.7%) formed the major bulk. HER2 expression was observed in 26.7% of Tumours, predominantly in males (p=0.006) and intestinal type (p= 0.054). HER2 expression correlated with Tumour grade (moderately differentiated and well differentiated, p= 0.042). Tumours of gastro-esophageal junction (GEJ) showed HER2 expression in 45.5% as opposed to 22.4% in gastric location. Poorly differentiated and diffuse type of adenocarcinomas did not express HER2. Two of three Tumours from patients in the age group 31-40 y expressed HER2. Conclusion: Male gender, intestinal-type and moderately differentiated gastric cancers may be the ones that can be targeted for therapy using Herceptin. Though trastusumab is approved for advanced gastric and GEJ cancers, it’s role in adjuvant/neo-adjuvant setting in early stages needs to be evaluated with newer agents like Pertuzumab, Bevacizumab, especially in young patients. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.

Loading Kempegowda Institute of Medical SciencesKarnataka collaborators
Loading Kempegowda Institute of Medical SciencesKarnataka collaborators