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Chow P.Y.,Kemin Industries Asia Pte Ltd | Gue S.Z.,Kemin Industries Asia Pte Ltd | Leow S.K.,Kemin Industries Asia Pte Ltd | Goh L.B.,Kemin Industries Asia Pte Ltd
Powder Technology | Year: 2015

The application of carotenoids as natural additives in various water-based or water-compatible formulations for the pigmentation of food and feed is seriously hampered by their insolubility in aqueous systems, resulting in low bioavailability. One way to develop the full potential of color strength and achieve a high degree of bioavailability during the gastrointestinal passage is to transform the coarse crystalline material into a nanodispersed state. Exemplified with natural carotenoid (Paprika Oleoresin), the objectives of this study were to prepare solid self-microemulsifying carotenoid system (S-SMECS) containing bicontinuous microemulsion of polyethoxylated sorbitan ester (Tween 80), water, R-(+)-limonene, ethanol, and glycerol with excellent in vivo solubilization capacity, for the delivery of bioactive carotenoid, by spraying the self-microemulsifying carotenoid system (liquid system) using colloidal silica/wheat pollard (as the inert solid carrier), and to evaluate the enhanced bioavailability and pigmentation efficacy of carotenoid from the S-SMECS. Results showed that the carotenoid solubilized better in the microemulsion and the self-microemulsifying carotenoid microemulsion is characterized by an average particle size of approximately 0.25. μm. The bioavailability study performed in layers resulted in enhanced values for the S-SMECS. The enhancement for S-SMECS was 17% above the level of carotenoid absorbed in the serum and the relative color score was 20-30% enhancement over feeding compared with the commercial product, respectively. These results demonstrated the excellent ability of S-SMECS containing bicontinuous microemulsion to enhance the bioavailability of carotenoid in vivo. © 2015 Elsevier B.V.


Chow P.Y.,Kemin Industries Asia Pte Ltd | Gue S.Z.,Kemin Industries Asia Pte Ltd | Leow S.K.,Kemin Industries Asia Pte Ltd | Goh L.B.,Kemin Industries Asia Pte Ltd
British Poultry Science | Year: 2014

1. This study was designed to test the hypothesis that microemulsified carotenoid products show improved bioavailability over corresponding regular preparations, leading to greater yolk pigmentation at lower dosages.2. The first trial was conducted using a maize-soya bean basal diet supplemented with either 0.25, 0.5, 0.75, 1.0 and 1.25 g/kg of microemulsified Red or non-microemulsified Red. The second trial involved feeding microemulsified Yellow or non-microemulsified Yellow using a similar dosage range. The layers were divided into 4 replicates of 8 layers each (32 layers per treatment). The 8 cages of layers were fed from a single feed trough. Feed and water were provided ad libitum throughout the trial. Each week, the eggs were collected. The whole liquid egg colour was determined by means of a commercially available yolk colour fan. Where required, HPLC-(high-performance liquid chromatography) based analysis of trans-capsanthin or trans-lutein equivalents using the Association of Analytical Communities method was carried out. Data were statistically analysed by one-way ANOVA method using Statgraphics.3. Results showed that the colour and carotenoid content of the egg yolk increased with increasing amount of carotenoids in the diet. The colour of egg yolks from layers fed similar concentrations of microemulsified versus the regular preparation was significantly different. At the commercial recommended dose of one g/kg regular Yellow or Red product, the microemulsified pigmenter is able to provide the equivalent yolk colour at a 20-30% lower dose.4. In conclusion, the trial results supported the hypothesis that a desired yolk colour score is achievable at a significantly lower inclusion rate when carotenoid molecules are emulsified using the microemulsion nanotechnology. © 2014 © 2014 British Poultry Science Ltd.

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