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West Des Moines, IA, United States

A nutritional intervention composition for reducing post-prandial blood glucose levels in humans, including between about 0.1 mg and about 10 mg of a proteinase inhibitor that is administered prior to the meal. The composition is effective for treating or ameliorating the effects of hyperglycemia and Type II diabetes. The composition also is effective in combating obesity. The proteinase inhibitor is preferably isolated from plant material, such as potatoes, soy, and beans. Potato proteinase inhibitor II and soybean Bowman-Birk inhibitor are included in the group of effective proteinase inhibitors.

Kemin Foods | Date: 2000-07-04

Dietary supplements.

Emmick T.K.,Kemin Foods | Herrlinger K.A.,Kemin Foods
Journal of the International Society of Sports Nutrition

Background The sports nutrition industry is seeing growth in consumers who are embarking on high intensity daily workout routines to regain and maintain physical fitness. This type of demanding training results in exercise-induced muscle damage setting off a cascade of increased oxidative stress and inflammation which in turn leads to reduced strength and increased delayed onset muscle soreness (DOMS) for days post-training. Consumption of antioxidants and anti-inflammatory molecules is crucial to counteract these negative side effects. A proprietary polyphenolic blend of catechins and theaflavins (PPCT) was formulated and evaluated in a randomized, doubleblind, placebo controlled human trial to determine the effect on exercise performance recovery following eccentric exercise. Methods Male participants (age 18-35 years) volunteered and were randomized to receive either a placebo or PPCT (2,000 mg) daily for 13 weeks. During the 13th week of supplementation, subjects performed a 40 minute downhill treadmill run (65% of VO2max) with 3 sets of isokinetic leg extension measurements taken at baseline (pre-exercise), 24, 48 and 96 hours post-exercise. Delayed onset muscle soreness (DOMS), muscle damage via creatine kinase (CK), oxidative stress via ferric reducing antioxidant power (FRAP), and a stress hormone (cortisol) were also examined at these timepoints. Consent to publish the results was obtained from all participants. Results The treatment group regained strength as measured by peak torque to 98% and 101% of pre-exercise levels at 48 and 96 hours post-exercise, respectively. In comparison the placebo group's peak torque levels remained at 92 % and 93% of pre-exercise levels at the same time points post-exercise. These improvements were significant compared to placebo at both time points (p < 0.05). Additionally, participants in the PPCT group reported decreased whole body and hamstring DOMS compared to placebo at 48 hours (p = 0.029 for both). These enhancements in strength and DOMS were also supported by improvements in serum markers of oxidative stress, muscle damage and inflammation. Chronic consumption of PPCT improved serum antioxidant status (p = 0.039) as measured by FRAP. As expected, serum cortisol increased in all groups compared to pre-exercise levels; however by 96 hours, serum cortisol levels had returned to pre-exercise levels in the PPCT group while the placebo remained 20% above pre-exercise levels (p < 0.05). Creatine kinase (CK) increased in both groups peaking at 24 hours post-exercise. CK levels returned to pre-exercise values at 96 hours in the PPCT groups while levels in the placebo group remained significantly elevated 50% over pre-exercise levels (p < 0.05) at the same time point. These reductions in cortisol and CPK levels occur simultaneous to the recovery in pre-exercise strength observed at 96 hours. Conclusions Daily supplementation with PPCT was shown to reduce DOMS and promote recovery of muscle strength by reducing the oxidative stress and markers of muscle damage that occurs post-exercise. © 2014 Emmick and Herrlinger; licensee BioMed Central Ltd. Source

Katz A.,Winthrop University | Efros M.,Winthrop University | Kaminetsky J.,New York University | Herrlinger K.,Kemin Foods | And 2 more authors.
Therapeutic Advances in Urology

Objectives: The objective of this study was to examine the effects of a green and black tea extract blend [AssuriTEA Mens Health (AMH)] in men with lower urinary tract symptoms (LUTS). Methods: In this randomized, double-blind, placebo-controlled study, 46 men aged 3070 with an American Urologic Association symptom score (AUAss) of at least 8 and up to 24 were randomized to 500 mg AMH, 1000 mg AMH, or placebo daily for 12 weeks. Measurements were taken at baseline (BL), week 6 and week 12 for AUAss, simple uroflowmetry, postvoid residual volume (PVR), C-reactive protein (CRP), Short-Form 36 Health Survey (SF-36), and International Index of Erectile Function (IIEF). Results: A total of 40 subjects completed the study. AUAss decreased 34.5% from BL to week 12 in the 1000 mg AMH group (p = 0.008). At week 12, CRP increased in the 500 mg AMH (p = 0.003) and placebo (p = 0.012) groups from their BL levels but not in the 1000 mg group. Average urine flow (Qmean) increased in the 500 mg (p = 0.033) and 1000 mg AMH (p = 0.002) groups versus placebo. PVR decreased in the 1000 mg AMH group (p = 0.034) from BL at week 6. Treatment group effects were observed for the physical functioning and sexual desire domains of the SF-36 and IIEF (p = 0.051 and p = 0.005 respectively). AMH was well tolerated. Conclusions: Oral administration of AMH improved LUTS and quality of life in as little as 6 weeks. © The Author(s), 2014. Source

Herrlinger K.A.,Kemin Foods | Chirouzes D.M.,Kemin Foods | Ceddia M.A.,Kemin Foods
Food and Nutrition Research

Background: Exercise can initiate a cascade of inflammatory and oxidative stress-related events leading to delayed onset muscle soreness. Polyphenols possess antioxidant and anti-inflammatory properties. Objective: The current study examined the effects of a proprietary polyphenolic blend (PB), containing catechins and theaflavins, on exercise performance and recovery following an eccentric exercise challenge. Design: Male participants (18-35 years of age) received placebo or PB at a low dose (PB-L, 1,000 mg/d) or high dose (PB-H, 2,000 mg/d) for 13 weeks. During the 13th week of supplementation, participants completed an eccentric exercise (40 min downhill treadmill run) followed by a strength assessment (peak torque on isokinetic leg extensions) pre-exercise, and 24, 48, and 96 h post-exercise. Muscle soreness (subjective questionnaire), markers of muscle stress (cortisol and creatine phosphokinase [CK]), and antioxidant capacity (ferric reducing ability of plasma [FRAP]) were also assessed. Results: PB-H attenuated the decrease in peak torque observed in the placebo group from pre-exercise to 48 h (p=0.012) and 96 h (p=0.003) post-exercise. At 48 h post-exercise, PB-H reduced whole body and hamstring soreness (p=0.029) versus placebo. Chronic consumption of PB improved serum FRAP (p=0.039). As expected, serum cortisol and CK increased from pre- to post-exercise in all groups; however, by 96 h, cortisol andCKlevels returned to pre-exercise levels following PB supplementation. At 96 h, the change in cortisol from pre- to post-exercise was significantly greater in placebo versus PB-H (p=0.039). Conclusion: These findings show that chronic consumption of PB improved antioxidant status, reduced markers of muscle stress, and promoted strength recovery post-exercise. © 2015 Kelli A. Herrlinger et al. Source

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