The Kemerovo State University was established in 1973 as a successor to Kemerovo Pedagogical Institute. It is a leading educational and scientific center of Kemerovo Oblast with five branches throughout the oblast in Belovo, Anzhero-Sudzhensk, Novokuznetsk, Prokopyevsk, as well as in Ulan Bator in Mongolia. Wikipedia.
Yuzhalin A.,Kemerovo State University
Human Immunology | Year: 2011
Gastric carcinoma is one of the most widespread malignancies worldwide. Interleukins are the key group of cytokines which may have tumor-promoting or tumor-suppressing effect, and receptors for them, of course, have the same importance in this context. However, mechanisms of their impact on tumor are not fully understood up to date. Numerous studies provide conflicting data, that makes picture more confusing and complicated. It is known that single nucleotide polymorphisms in interleukin genes may dramatically affect on protein expression level, or alter its functions, which may lead to gastritis or ulcer, and eventually promote cancer occurrence. Furthermore, some of these genetic polymorphisms may serve as predictive factors for cancer prognosis and prevention. In order to understand the impact of each genetic polymorphism, the review of IL-1B, IL-4, IL-6, IL-8, IL-10, IL17A, IL-17F DNA polymorphisms on gastric carcinoma was done, and risk alleles were recommended for further research. © 2011 American Society for Histocompatibility and Immunogenetics.
Basalaev Yu.M.,Kemerovo State University
Journal of Structural Chemistry | Year: 2016
Three possible models of the ordered arrangement of B, C, and N atoms in chalcopyrite sublattices are considered. Crystal lattice parameters are obtained from the first principles, band spectra are calculated, and the role of B, C, and N atoms in the formation of chemical bonds and the valence band in the B2CN, BC2N, and BCN2 crystals is revealed. © 2016 Pleiades Publishing, Ltd.
Yuzhalin A.E.,Kemerovo State University |
Kutikhin A.G.,Kemerovo State Medical Academy
Free Radical Research | Year: 2012
Antioxidant defence enzymes are essential protectors of living organisms against oxidative stress. These enzymes are involved in the detoxification and decomposition of harmful chemical compounds called reactive oxygen species (ROS), which are, first and foremost, a source of intracellular oxidative stress. ROS directly promote the oxidative damage of genes resulting in aberrant regulation of many vital cell processes. As a consequence, the presence of ROS can lead to genomic instability, deregulation of transcription, induction of mitogenic signal transduction pathways and replication errors, all of which may increase the risk of cancer development. Single nucleotide polymorphisms of antioxidant defence genes may significantly modify the functional activity of the encoded proteins; therefore, certain alleles can be established as risk factors for particular cancer types. In the future, these risk alleles may be utilized as genomic markers of cancer predisposition to allow for early prevention measures among carriers of these alleles. The review is devoted to common single nucleotide polymorphisms of the superoxide dismutase (SOD) and glutathione peroxidase (GPX) gene families and their impact on carcinogenesis. The predictive significance of several polymorphisms was determined, and these polymorphisms were recommended for further in-depth research. © 2012 Informa UK, Ltd.
Poplavnoi A.S.,Kemerovo State University
Journal of Structural Chemistry | Year: 2013
The features of pseudosymmetry in crystalline compounds with highly symmetric sublattices are discussed. The symmetry of sublattices higher than the crystal symmetry is manifested in elementary excitation spectra in the form of degenerations and quasidegenerations. The topology of spectral branches is not related to the value of the parameter estimating the degree of pseudosymmetry on the basis of the electron density fraction, which is invariant with respect to operations corresponding to additional symmetry. © 2013 Pleiades Publishing, Ltd.
Chuesheva O.A.,Kemerovo State University
Journal of Siberian Federal University - Mathematics and Physics | Year: 2014
In this article we construct all kinds of elementary Prym differentials for arbitrary characters on a variable torus with a finite numbers of punctures and find the dimensions of two important quotient spaces. As a consequence, this yields the dimension of the first holomorphic de Rham cohomology group of Prym differentials for arbitrary characters on torus. Also, we construct explicit bases in these quotient spaces. © Siberian Federal University. All rights reserved.